Comparison Results | RestoredCDC.org

Comparison timestamp: 2025-05-07 00:54:25 UTC
RestoredCDC URL: http://restoredcdc.org/www.cdc.gov/vaccines/vpd/hpv/hcp/vaccines.html
Live cdc.gov URL ↗: https://www.cdc.gov/vaccines/vpd/hpv/hcp/vaccines.html
Removed: Line removed from cdc.gov. Specific word removals are highlighted.
Added: Line added to cdc.gov. Specific word additions are highlighted.
Injected: Line or disclaimer added by RestoredCDC.org.
Unchanged: Line unchanged.
Enable word-level highlighting (experimental)? High contrast mode
    Original site: www.cdc.gov/vaccines/vpd/hpv/hcp/vaccines.html | RestoredCDC.org is an independent project, not affiliated with CDC or any federal entity. Visit CDC.gov for free official information. Due to archival on January 6, 2025, recent outbreak data is unavailable. Videos are not restored. Access data.restoredcdc.org for restored data. Use of this site implies acceptance of this disclaimer.
    [More]
    About Us Report Bug Compare Content
  Skip directly to site content Skip directly to search
  Español | Other Languages
    Here's how you know
    An official website of the United States government Here's how you know
        Vaccines & Immunizations
        Vaccines & Immunizations
        Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People Vaccines & Immunizations
          Search
            Search Menu Navigation Menu
                Submit
    Vaccines & Immunizations
      * Vaccines by Disease
              + BACK
                Vaccines by Disease
          + COVID-19
          + Dengue
          + Diphtheria
          + Diphtheria, Tetanus, and Pertussis
          + Hepatitis A
          + Hepatitis B
          + Hib (Haemophilus influenzae type b)
          + HPV (Human Papillomavirus)
                  o BACK
                    HPV (Human Papillomavirus)
                  o BACK
                    Vaccines by Disease HPV (Human Papillomavirus)
              o About HPV Vaccines
              o Vaccines & Immunizations Home
          + Influenza (Flu)
          + Measles, Mumps, and Rubella
          + Meningococcal
          + Mpox
          + Pneumococcal
          + Polio (Poliomyelitis)
          + Rotavirus
          + RSV (Respiratory Syncytial Virus)
          + Shingles (Herpes Zoster)
          + Varicella (Chickenpox)
          + Adenovirus
          + Anthrax
          + Chikungunya
          + Cholera
          + Ebola
          + Japanese Encephalitis (JE)
          + Rabies
          + Smallpox
          + Tuberculosis
          + Typhoid Fever
          + Yellow Fever
          + Vaccines & Immunizations Home
      * Vaccines & Immunizations Home
          Vaccines & Immunizations
    Vaccines & Immunizations Home
      About HPV Vaccines
        About HPV Vaccines
        Print
            Related Pages
            Vaccine Composition
            9-valent HPV vaccine (Gardasil-9 [23 pages]) is a non-infectious recombinant vaccine prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58.
            Immunogenicity and Vaccine Efficacy
                HPV Vaccine Efficacy
                  * High efficacy among persons without evidence of prior infection with HPV vaccine types
                  * No evidence of efficacy against disease caused by HPV types with which participants were already infected at the time of vaccination
                  * Prior infection with one HPV vaccine type did not diminish efficacy of vaccine against the other HPV vaccine types
            HPV vaccines are highly immunogenic. More than 98% of recipients develop an antibody response to HPV types included in the respective vaccines 1 month after completing a full vaccination series.
              * However, there is no known serologic correlate of immunity and no known minimum titer determined to be protective.
              * The high efficacy found in the clinical trials to date has precluded identification of a minimum protective antibody titer.
            All HPV vaccines have been found to have high efficacy (close to 100%) for prevention of HPV vaccine type-related persistent infection, cervical intraepithelial neoplasia (CIN) 2/3, and adenocarcinoma in situ (AIS) in clinical trials in analyses limited to persons without evidence of infection with the vaccine types at the time of vaccination. The initial trials were conducted in women aged 15 or 16 through age 26 years, following a three-dose vaccination schedule. Quadrivalent vaccine was also found to have high efficacy (99%) for prevention of genital warts. Among men who have sex with men (MSM), quadrivalent vaccine had high efficacy against anal intraepithelial neoplasia grade 2 or 3 (AIN 2/3).
            Immunogenicity trials conducted several years after the original vaccine licensures demonstrated that the antibody response after two doses given 6 to 12 months apart in 9- through 14-year-olds was non-inferior to the antibody response after three doses in women in the age group in which efficacy was demonstrated in the clinical trials. These studies led to approval and recommendation of a two-dose schedule in young adolescents.
            For more efficacy studies, see the Pink Book Chapter on HPV.
              Related Pages
                * HPV Website for Healthcare Professionals
                * Ask the Experts: HPV
                * Pink Book Chapter on Human Papillomavirus
                * HPV Vaccine Recommendations [24 pages]
            Top of Page
      Last Reviewed: November 16, 2021
        Source: National Center for Immunization and Respiratory Diseases
        * Facebook
        * Twitter
        * LinkedIn
        * Syndicate
      home Vaccines & Immunizations Home
      * Vaccines by Disease plus icon
          + COVID-19
          + Dengue
          + Diphtheria
          + Diphtheria, Tetanus, and Pertussis
          + Hepatitis A
          + Hepatitis B
          + Hib (Haemophilus influenzae type b)
          + HPV (Human Papillomavirus)
              o About HPV Vaccines
          + Influenza (Flu)
          + Measles, Mumps, and Rubella
          + Meningococcal
          + Mpox
          + Pneumococcal
          + Polio (Poliomyelitis)
          + Rotavirus
          + RSV (Respiratory Syncytial Virus)
          + Shingles (Herpes Zoster)
          + Varicella (Chickenpox)
          + Adenovirus
          + Anthrax
          + Chikungunya
          + Cholera
          + Ebola
          + Japanese Encephalitis (JE)
          + Rabies
          + Smallpox
          + Tuberculosis
          + Typhoid Fever
          + Yellow Fever
              * About CDC
              * Contact Us
              * 800-232-4636
              Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
              Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat RSS
          * CONTACT CDC
                    Contact Us
                    Call 800-232-4636
                    Email Us
          * ABOUT CDC
                  + About CDC
                  + Jobs
                  + Funding
          * POLICIES
                  + Accessibility
                  + External Links
                  + Privacy
                  + Policies
                  + Web Policies
                  + No Fear Act
                  + FOIA
                  + OIG
                  + No Fear Act
                  + Nondiscrimination
                  + Vulnerability Disclosure Policy
                  + CDC Archive
                  + Public Health Publications
                  + HHS.gov
                  + USA.gov
          * CONNECT WITH US
                    + Facebook
                    + Twitter
                    + Instagram
                    + LinkedIn
                    + Youtube
                    + Pinterest
                    + Snapchat
                    + Email
          * LANGUAGES
                  + Español
                  + 繁體中文
                  + Tiếng Việt
                  + 한국어
                  + Tagalog
                  + Русский
                  + العربية
                  + Kreyòl Ayisyen
                  + Français
                  + Polski
                  + Português
                  + Italiano
                  + Deutsch
                  + 日本語
                  + فارسی
                  + English
          * U.S. Department of Health & Human Services
          * Accessibility
          * External Links
          * Privacy
          * Policies
          * Web Policies
          * FOIA
          * OIG
          * No Fear Act
          * FOIA
          * Nondiscrimination
          * OIG
          * Vulnerability Disclosure Policy
          * CDC Archive
          * Public Health Publications
          * HHS.gov
          * USA.gov
        Content Credential
        ×
        This image was edited or created using GenAI (generative artificial intelligence).
        Our experts review all images in an effort to ensure accuracy and quality before use.
        Learn more about CDC's usage of GenAI.
Note: Comparison ignores leading/trailing whitespace and certain script/tracking codes. Word-level highlighting (optional above) only applies to changed lines.