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Reported Tuberculosis in the United States, 2023
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October 31, 2024
TB Characteristics in wgMLSType Clusters: 2021–2023
Characteristics of Tuberculosis Cases in wgMLSType Clusters by Alert Levels Based on Log-Likelihood Ratio (LLR): United States, 2021–2023
What to know
This table describes the characteristics of tuberculosis (TB) disease cases in whole genome sequencing (wgMLSType) clusters by alert levels based on log-likelihood ratio in the United States from 2021 to 2023.
Characteristics of Tuberculosis Cases in wgMLSType Clusters1 by Alert Levels Based on Log-Likelihood Ratio (LLR):2 United States, 2021–2023
CDC describes cases of TB disease in whole genome sequencing clusters by alert level, 2021-2023.
Characteristics Unique Clustered Alert levels for clustered cases3
Non-alerted Medium High
(LLR <4) (LLR 4 – <10) (LLR ≥10)
No. (%) No. (%) No. (%) No. (%) No. (%)
Total 16,061 (82.6) 3,384 (17.4) 1,253 (37.0) 1,325 (39.2) 806 (23.8)
Origin of birth4
U.S.-born 2,874 (62.0) 1,758 (38.0) 507 (28.8) 621 (35.3) 630 (35.8)
Non-U.S.–born 13,125 (89.1) 1,613 (10.9) 739 (45.8) 699 (43.3) 175 (10.8)
Unknown or missing 62 (82.7) 13 (17.3) 7 (53.8) 5 (38.5) 1 (7.7)
Race and ethnicity5
Hispanic or Latino 5,132 (77.0) 1,531 (23.0) 727 (47.5) 560 (36.6) 244 (15.9)
American Indian or Alaska Native 75 (33.8) 147 (66.2) 3 (2.0) 30 (20.4) 114 (77.6)
Asian 6,316 (94.8) 346 (5.2) 137 (39.6) 189 (54.6) 20 (5.8)
Black or African American 2,399 (74.9) 806 (25.1) 208 (25.8) 293 (36.4) 305 (37.8)
Native Hawaiian or Other Pacific Islander 115 (43.7) 148 (56.3) 40 (27.0) 88 (59.5) 20 (13.5)
White 1,531 (82.8) 318 (17.2) 118 (37.1) 129 (40.6) 71 (22.3)
Multiple race 324 (84.8) 58 (15.2) 12 (20.7) 24 (41.4) 22 (37.9)
Unknown or missing 62 (77.5) 18 (22.5) 3 (16.7) 5 (27.8) 10 (55.6)
Age group (years)6
0–4 55 (32.7) 113 (67.3) 26 (23.0) 58 (51.3) 29 (25.7)
5–14 135 (60.3) 89 (39.7) 19 (21.3) 43 (48.3) 27 (30.3)
15–24 1,481 (75.8) 472 (24.2) 200 (42.4) 181 (38.3) 91 (19.3)
25–44 4,652 (79.7) 1,185 (20.3) 442 (37.3) 466 (39.3) 277 (23.4)
45–64 4,581 (80.6) 1,102 (19.4) 390 (35.4) 414 (37.6) 298 (27.0)
≥65 5,156 (92.4) 423 (7.6) 176 (41.6) 163 (38.5) 84 (19.9)
Disease site
Pulmonary only 11,502 (81.1) 2,686 (18.9) 976 (36.3) 1,066 (39.7) 644 (24.0)
Extrapulmonary 2,458 (89.5) 287 (10.5) 119 (41.5) 97 (33.8) 71 (24.7)
Both 2,055 (83.5) 407 (16.5) 158 (38.8) 158 (38.8) 91 (22.4)
Unknown 46 (92.0) 4 (8.0) 0 (0.0) 4 (100.0) 0 (0.0)
Sputum smear
Positive 7,967 (80.1) 1,979 (19.9) 719 (36.3) 786 (39.7) 474 (24.0)
Negative 6,448 (85.3) 1,111 (14.7) 439 (39.5) 410 (36.9) 262 (23.6)
Not done 1,449 (84.6) 263 (15.4) 83 (31.6) 113 (43.0) 67 (25.5)
Unknown or missing 197 (86.4) 31 (13.6) 12 (38.7) 16 (51.6) 3 (9.7)
Cavitary disease7
Yes 167 (77.7) 48 (22.3) 18 (37.5) 19 (39.6) 11 (22.9)
No 1,442 (83.2) 292 (16.8) 124 (42.5) 104 (35.6) 64 (21.9)
Unknown or missing 9 (90.0) 1 (10.0) 0 (0.0) 1 (100.0) 0 (0.0)
Homeless within past year
Yes 688 (64.5) 378 (35.5) 176 (46.6) 104 (27.5) 98 (25.9)
No 15,195 (83.6) 2,970 (16.4) 1,065 (35.9) 1,206 (40.6) 699 (23.5)
Unknown or missing 178 (83.2) 36 (16.8) 12 (33.3) 15 (41.7) 9 (25.0)
Excess alcohol use within past year
Yes 1,201 (70.2) 511 (29.8) 159 (31.1) 189 (37.0) 163 (31.9)
No 14,572 (83.8) 2,808 (16.2) 1,062 (37.8) 1,113 (39.6) 633 (22.5)
Unknown or missing 288 (81.6) 65 (18.4) 32 (49.2) 23 (35.4) 10 (15.4)
Injecting drug use within past year
Yes 124 (61.1) 79 (38.9) 24 (30.4) 26 (32.9) 29 (36.7)
No 15,619 (82.9) 3,225 (17.1) 1,190 (36.9) 1,277 (39.6) 758 (23.5)
Unknown or missing 318 (79.9) 80 (20.1) 39 (48.8) 22 (27.5) 19 (23.8)
Noninjecting drug use within past year
Yes 812 (55.0) 665 (45.0) 237 (35.6) 190 (28.6) 238 (35.8)
No 14,936 (84.9) 2,654 (15.1) 987 (37.2) 1,115 (42.0) 552 (20.8)
Unknown or missing 313 (82.8) 65 (17.2) 29 (44.6) 20 (30.8) 16 (24.6)
Resident of a correctional facility at time of diagnosis
Yes 371 (67.9) 175 (32.1) 64 (36.6) 44 (25.1) 67 (38.3)
No 15,600 (83.0) 3,189 (17.0) 1,180 (37.0) 1,271 (39.9) 738 (23.1)
Unknown or missing 90 (81.8) 20 (18.2) 9 (45.0) 10 (50.0) 1 (5.0)
HIV status
Positive 634 (75.7) 204 (24.3) 82 (40.2) 67 (32.8) 55 (27.0)
Negative 13,702 (82.2) 2,962 (17.8) 1,098 (37.1) 1,150 (38.8) 714 (24.1)
Refused 257 (91.8) 23 (8.2) 9 (39.1) 12 (52.2) 2 (8.7)
Not offered 517 (87.0) 77 (13.0) 33 (42.9) 29 (37.7) 15 (19.5)
Unknown, missing, or indeterminate 951 (89.0) 118 (11.0) 31 (26.3) 67 (56.8) 20 (16.9)
Multidrug-resistant TB8
Yes 234 (89.0) 29 (11.0) 5 (17.2) 18 (62.1) 6 (20.7)
No 15,141 (82.4) 3,236 (17.6) 1,213 (37.5) 1,254 (38.8) 769 (23.8)
Unknown or missing 686 (85.2) 119 (14.8) 35 (29.4) 53 (44.5) 31 (26.1)
1wgMLSType clusters have two or more cases with matching wgMLSType within a county during the specified 3-year time period.
2Alert levels are based on a log-likelihood ratio, which calculates the geographical concentration of a genotype in a county compared to the rest of the country during a 3-year period.
3There were 3,384 cases in 1,110 clusters: 806 cases were in 82 (7.4%) high alert clusters; 1,325 cases were in 496 (44.7%) medium alert clusters, and 1,253 cases were in 532 (47.9%) non-alert clusters.
4Persons born in the United States, certain U.S. territories, or elsewhere to at least one U.S. citizen parent are categorized as U.S.-born. All other persons are categorized as non-U.S.–born.
5Persons who identified as Hispanic or Latino were categorized as "Hispanic," regardless of self-reported race. Persons who did not identify as Hispanic or Latino were categorized by self-reported race; if more than one race was reported, the person was categorized as "Multiple race." Due to “Other race” being first reported as a new race category in 2023, information for 119 persons reporting “Other race” was not included in this table.
6One person with a unique wgMLSType and an unknown age was excluded.
7Cavitary disease only assessed for persons with pulmonary TB and an abnormal x-ray.
8Starting in 2023, information on drug resistance included results of molecular drug susceptibility testing in addition to growth-based susceptibility testing for isoniazid and rifampin. An isolate is considered resistant to isoniazid or rifampin if either the growth-based test or molecular test detects resistance.
Note
Data for all years are updated through July 17, 2024.
Resources
Tuberculosis in the United States, 2023 Slide Set
Download the slide set of data visualizations for Reported Tuberculosis in the United States, 2023.
Nov. 5, 2024
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Executive Commentary
CDC describes cases of tuberculosis disease in the United States reported in 2023.
Oct. 16, 2024
Table Printing Tips
Follow these instructions to print data tables in Reported Tuberculosis in the United States, 2023.
Oct. 28, 2024
Related Pages
* Data Tables
* TB by Pregnancy: 2023
* Non-HIV Medical Risk Factors for TB by Origin of Birth and Race/Ethnicity: 2023
* TB Clusters by Cluster Size: 2021–2023
*
* TB by Age Group and Reporting Areas: 2023
*
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TB Clusters by Cluster Size: 2021–2023
October 31, 2024
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Content Source:
Division of Tuberculosis Elimination; National Center for HIV, Viral Hepatitis, STD, and Tuberculosis Prevention; Centers for Disease Control and Prevention
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* Data Tables
* TB by Pregnancy: 2023
* Non-HIV Medical Risk Factors for TB by Origin of Birth and Race/Ethnicity: 2023
* TB Clusters by Cluster Size: 2021–2023
*
* TB by Age Group and Reporting Areas: 2023
*
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Reported Tuberculosis in the United States, 2023
Reported Tuberculosis in the United States, 2023 describes cases of tuberculosis (TB) disease reported to CDC during 1993–2023.
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