Comparison Results | RestoredCDC.org

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          The National Institute for Occupational Safety and Health (NIOSH)
         1. Registry of Toxic Effects of Chemical Substances (RTECS)
      Valeraldehyde
            Related Pages
                RTECS #
                  YV3600000
                CAS #
                  110-62-3
                  See: NMAM or OSHA Methods
                Updated
                  December 2016
                Molecular Weight
                  86.15
                Molecular Formula
                  C5H10O
                Synonyms
                  Amyl aldehyde
                  Butyl formal
                  n-Pentanal
                  n-Valeraldehyde
                  n-Valeraldehyde (ACGIH)
                  n-Valeric aldehyde
                  Pentanal
                  Valeral
                  Valerianic aldehyde
                  Valeric acid aldehyde
                  Valeric aldehyde
                  Valerylaldehyde
        Skin and Eye Irritation and References
          Route/Organism    Dose        Effect    Reference         
          eye /rabbit       100 mg/24H  severe    FCTXAV 17,919,1979
          skin /guinea pig  100%        severe    FCTXAV 17,919,1979
          skin /rabbit      500 mg/24H  moderate  FCTXAV 17,919,1979
          Mutation Data and Reference
            System Test                          Route/Organism/Tissue  Dose       Reference          
            mutation in mammalian somatic cells  lung/hamster           10 mmol/L  MUTAEX 4,277,1989  
            Unscheduled DNA Synthesis            liver/rat              3 µmol/L   MUREAV 323,121,1994
            Acute Toxicity Data and References
              Route/Organism              Dose                                                        Effect                                                                                                       Reference          
              In Vitro/Human, lung tumor  Inhibitor Concentration (20 percent kill): 1.7 mmol/L/48H   In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.  TXCYAC 334,111,2015
              In Vitro/Human, lung tumor  Inhibitor Concentration (10 percent kill): 1 mmol/L/48H     In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.  TXCYAC 334,111,2015
              In Vitro/Human, lung tumor  Inhibitor Concentration (50 percent kill): 0.75 mmol/L/48H  In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.  TXCYAC 334,111,2015
              In Vitro/Human, lung tumor  Inhibitor Concentration Low: 0.75 mmol/L/48H                In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.  TXCYAC 334,111,2015
              inhalation/rat              lethal concentration (50 percent kill): 14000 mg/m3/4H                                                                                                                   VCVGK* -,376,1984  
              inhalation/rat              Lowest published lethal concentration: 4000 ppm/4H                                                                                                                       AIHAAP 30,470,1969 
                                                                                                      Behavioral: Somnolence (general depressed activity)                                                                             
              intraperitoneal/mouse       lethal dose (50 percent kill): 200 mg/kg                    Behavioral: Muscle weakness                                                                                  NTIS** OTS0533619  
                                                                                                      Behavioral: Ataxia                                                                                                              
                                                                                                      Behavioral: Muscle weakness                                                                                                     
              intraperitoneal/rat         lethal dose (50 percent kill): 400 mg/kg                                                                                                                                 NTIS** OTS0533619  
                                                                                                      Behavioral: Ataxia                                                                                                              
              oral/mouse                  lethal dose (50 percent kill): 6.4 mg/kg                                                                                                                                 VCVGK* -,376,1984  
              oral/rat                    lethal dose (50 percent kill): 5.66 mg/kg                                                                                                                                VCVGK* -,376,1984  
              oral/rat                    lethal dose (50 percent kill): 5660 µL/kg                                                                                                                                AIHAAP 30,470,1969 
              skin/guinea pig             lethal dose (50 percent kill): 20 gm/kg                                                                                                                                  FCTXAV 17,919,1979 
              skin/rabbit                 lethal dose (50 percent kill): 5 mL/kg                      Skin: After systemic exposure: Dermatitis, other                                                             NTIS** OTS0535072  
              subcutaneous/mouse          lowest published lethal dose: 2 gm/kg                                                                                                                                    APFRAD 14,710,1956 
              Reviews
                Organization                                                       Standard                                            Reference          
                American Conference of Governmental Industrial Hygienists (ACGIH)  Threshold Limit Value-time-weighted average 50 ppm  DTLVS* TLV/BEI,2013
                TOXICOLOGY REVIEW                                                                                                      TOLED5 199,203,2010
                Standards and Regulations
                  Organization                                                                           Standard                                                  Reference
                  Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;                                                                     
                  Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV                                                                                         
                  Occupational Exposure Limit-AUSTRALIA                                                  time-weighted average 50 ppm (176 mg/m3), JUL2008                  
                  Occupational Exposure Limit-AUSTRIA                                                    MAK-TMW 50 ppm (175 mg/m3);KZW 100 ppm (350 mg/m3), 2007           
                  Occupational Exposure Limit-BELGIUM                                                    time-weighted average 50 ppm (179 mg/m3), MAR2002                  
                  Occupational Exposure Limit-DENMARK                                                    time-weighted average 50 ppm (175 mg/m3), MAY2011                  
                  Occupational Exposure Limit-FINLAND                                                    time-weighted average 30 ppm (110 mg/m3), NOV2011                  
                  Occupational Exposure Limit-FRANCE                                                     VME 50 ppm (175 mg/m3), FEB2006                                    
                  Occupational Exposure Limit-ICELAND                                                    time-weighted average 50 ppm (175 mg/m3), NOV2011                  
                  Occupational Exposure Limit-KOREA                                                      time-weighted average 50 ppm (175 mg/m3), 2006                     
                  Occupational Exposure Limit-MEXICO                                                     time-weighted average 50 ppm (175 mg/m3), 2004                     
                  Occupational Exposure Limit-NEW ZEALAND                                                time-weighted average 50 ppm (176 mg/m3), JAN2002                  
                  Occupational Exposure Limit-NORWAY                                                     time-weighted average 0.3 mg/m3, JAN1999                           
                  Occupational Exposure Limit-PERU                                                       time-weighted average 50 ppm (176 mg/m3), JUL2005                  
                  Occupational Exposure Limit-SWITZERLAND                                                MAK-week 50 ppm (175 mg/m3), JAN2011                               
                  Occupational Exposure Limit-THE NETHERLANDS                                            MAC-TGG 175 mg/m3, 2003                                            
                  NIOSH Documentation and Surveillance
                    Organization                                                                                                     Standard                                                                                                                                                                                Reference               
                    National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-VALERALDEHYDE-air  10H time-weighted average 50 ppm                                                                                                                                                        NIOSH* DHHS #92-100,1992
                    National Occupational Exposure Survey 1983                                                                       Hazard Code B0122; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 5; Total Number of Employees Exposed 1557; Total Number of Female Employees Exposed 276                          
                    Status in Federal Agencies
                      Organization                                               Reference
                      EPA TSCA Section 8(b) CHEMICAL INVENTORY                            
                      EPA TSCA Section 8(d) unpublished health/safety studies             
                      EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001           
                      NIOSH Analytical Method, 1994: Aldehydes, screening, 2539           
                      NIOSH Analytical Method, 1994: Valeraldehyde, 2536                  
                      NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991             
                      OSHA ANALYTICAL METHOD #85                                          
                    Page last reviewed: November 16, 2018
                      Content source: National Institute for Occupational Safety and Health
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