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Original site: www.cdc.gov/niosh-rtecs/YS882F48.html | RestoredCDC.org is an independent project, not affiliated with CDC or any federal entity. Visit CDC.gov for free official information. Due to archival on January 6, 2025, recent outbreak data is unavailable. Videos are not restored. Access data.restoredcdc.org for restored data. Use of this site implies acceptance of this disclaimer.[More]About Us Report Bug Compare ContentSkip directly to page optionsThe National Institute for Occupational Safety and Health (NIOSH)Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting PeopleSearchSearch Menu Navigation Menu× NIOSHNIOSH All CDCSubmit* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS Database* The National Institute for Occupational Safety and Health (NIOSH) HomeThe National Institute for Occupational Safety and Health (NIOSH)1. Registry of Toxic Effects of Chemical Substances (RTECS)Urea, 3-(3,4-dichlorophenyl)-1,1-dimethyl-Related PagesRTECS #YS8925000CAS #330-54-1; 102962-29-8See: NMAM or OSHA MethodsUpdatedDecember 2017Molecular Weight233.11Molecular FormulaC9H10Cl2N2OSynonyms1-(3,4-Dichlorophenyl)-3,3-dimethyluree (French)1,1-Dimethyl-3-(3,4-dichlorophenyl)urea3-(3,4-Dichloor-fenyl)-1,1-dimethylureum (Dutch)3-(3,4-Dichlorophenol)-1,1-dimethylurea3-(3,4-Dichlorophenyl)-1,1-dimethylurea3-(3,4-Dichlor-phenyl)-1,1-dimethyl-harnstoff (German)3-(3,4-Dicloro-fenyl)-1,1-dimetil-urea (Italian)AF 101DCMUDichlorfenidimDirex 4LDiuronDiuron (ACGIH)Diuron 4LDMUDP Hardener 95DuranFarmco diuronHerbatoxHW 920KarmexKarmex Diuron HerbicideKarmex DWLucenitMarmerN'-(3,4-Dichlorophenyl)-N,N-dimethylureaSup'r floTelvar diuron weed killerUnidronUSAF P-7USAF XR-42Mutation Data and ReferenceSystem Test Route/Organism/Tissue Dose ReferenceCytogenetic Analysis liver/hamster 0.45 mg/L/20H MUREAV 721,89,2011Cytogenetic Analysis ovary/hamster 45 mg/L/20H MUREAV 721,89,2011DNA inhibition oral/mouse 1 gm/kg MUREAV 58,353,1978micronucleus test intraperitoneal/mouse 170 mg/kg HBPTO* 2,1523,2001mutation in microorganisms /Salmonella typhimurium 3 µg/plate (-enzymatic activation step) MUREAV 58,353,1978sister chromatid exchange liver/hamster 45 mg/L MUREAV 721,89,2011Reproductive Effects Data and ReferencesRoute/Organism Dose Effect Referenceoral/rat 360 mg/kg (6-15D pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) GISAAA 49(8),83,1984oral/rat 1250 mg/kg (6-15D pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system BECTA6 22,522,1979Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)oral/rat 3750 mg/kg (30D male) REPTED 23,106,2007Reproductive: Effects on embryo or fetus: Fetal deathoral/rat 3750 mg/kg (30D male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) REPTED 23,106,2007Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)subcutaneous/mouse 1935 mg/kg (6-14D pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** PB223-160Reproductive: Specific developmental abnormalities: Eye, earunreported route/mammal (species unspecified) 144 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FEREAC 64,41302,1999Tumorigenic Data and ReferencesRoute/Organism Dose Effect ReferenceTumorigenic: Equivocal tumorigenic agent by RTECS criteriaoral/mouse lowest published toxic dose: 153 gm/kg/78W- intermittent Lung, Thorax, or Respiration: Tumors NTIS** PB223-159Blood: TumorsAcute Toxicity Data and ReferencesRoute/Organism Dose Effect ReferenceIn Vitro Toxicity Studies: Cell countingIn Vitro/Human, embryonic cells Inhibitor Concentration Low: 200 µmol/L/24H TIVIEQ 29,1577,2015In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.In Vitro/Human, embryonic cells Inhibitor Concentration Low: 200 µmol/L/48H TIVIEQ 29,1577,2015In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.In Vitro/Human, embryonic cells Inhibitor Concentration Low: 50 µmol/L/72H In Vitro Toxicity Studies: Cell counting TIVIEQ 29,1577,2015In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.In Vitro/Human, embryonic cells Inhibitor Concentration Low: 200 µmol/L/72H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 29,1577,2015In Vitro Toxicity Studies: Other assaysIn Vitro/jrd Inhibitor Concentration Low: 200 µmol/L/48H In Vitro Toxicity Studies: Cell counting TIVIEQ 29,1577,2015In Vitro/jrd Inhibitor Concentration Low: 200 µmol/L/24H In Vitro Toxicity Studies: Other assays TIVIEQ 29,1577,2015In Vitro/jrd Inhibitor Concentration Low: 100 µmol/L/48H In Vitro Toxicity Studies: Other assays TIVIEQ 29,1577,2015In Vitro/jrd Inhibitor Concentration Low: 10 µmol/L/72H In Vitro Toxicity Studies: Other assays TIVIEQ 29,1577,2015intraperitoneal/mouse lethal dose (50 percent kill): 500 mg/kg NTIS** AD277-689Behavioral: General anestheticoral/rat lethal dose (50 percent kill): 1017 mg/kg JAFCAU 18,1104,1970Behavioral: Ataxiaoral/rat lethal dose (50 percent kill): 1 gm/kg HBPTO* 2,1522,2001skin/rat lethal dose (50 percent kill): >5 gm/kg FMCHA2 -,C115,1991Tank with water/Shrimp lethal concentration (50 percent kill): 8800 µg/L/96H EESADV 73,360,2010unreported route/duck lethal dose (50 percent kill): >2 gm/kg FMCHA2 -,C115,1991unreported route/rat lethal dose (50 percent kill): 3400 mg/kg 30ZDA9 -,231,1971Other Multiple Dose Data and ReferencesRoute/Organism Dose Effect ReferenceKidney, Ureter, and Bladder: Proteinuriainhalation/rat lowest published toxic concentration: 90 mg/m3/4H/60D- intermittent Blood: Changes in spleen GISAAA 34(6),27,1969Endocrine: Changes in thyroid weightBlood: Changes in bone marrow not included in aboveoral/rat lowest published toxic dose: 10 gm/kg/10D- intermittent Blood: Changes in spleen HBPTO* 2,1522,2001Nutritional and Gross Metabolic: Weight loss or decreased weight gainBlood: Normocytic anemiaoral/rat lowest published toxic dose: 9 gm/kg/30D- continuous HBPTO* 2,1522,2001Nutritional and Gross Metabolic: Weight loss or decreased weight gainEndocrine: Changes in spleen weightoral/rat lowest published toxic dose: 18 gm/kg/30D- continuous HBPTO* 2,1522,2001Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldoral/rat lowest published toxic dose: 3375 mg/kg/90D- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1522,2001Blood: Normocytic anemiaoral/rat lowest published toxic dose: 16.88 gm/kg/90D- continuous HBPTO* 2,1522,2001Blood: Changes in bone marrow not included in aboveEndocrine: Changes in spleen weightoral/rat lowest published toxic dose: 7987.5 mg/kg/426D- continuous Blood: Normocytic anemia HBPTO* 2,1523,2001Blood: Changes in cell count (unspecified)oral/rat lowest published toxic dose: 5000 mg/kg/10D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1523,2001oral/rat lowest published toxic dose: 682.5 mg/kg/13W- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) HBPTO* 2,1523,2001Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladderoral/rat lowest published toxic dose: 21000 mg/kg/20W- continuous TXCYAC 224,66,2006Nutritional and Gross Metabolic: Weight loss or decreased weight gainoral/rat lowest published toxic dose: 4200 mg/kg/20W- continuous Kidney, Ureter, and Bladder: Other changes TXCYAC 224,66,2006oral/rat lowest published toxic dose: 3750 mg/kg/30D- intermittent Liver: Changes in liver weight REPTED 23,106,2007Kidney, Ureter, and Bladder: Bladder tumorsoral/rat lowest published toxic dose: 3416 mg/kg/20W- continuous TXCYAC 312,1,2013Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladderKidney, Ureter, and Bladder: Changes in kidney weightoral/rat lowest published toxic dose: 8414 mg/kg/20W- continuous Endocrine: Changes in spleen weight TXCYAC 312,1,2013Blood: Changes in spleenoral/rat lowest published toxic dose: 14224 mg/kg/20W- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 312,1,2013Behavioral: Food intake (animal)oral/rat lowest published toxic dose: 1422.4 mg/kg/2W- continuous TXCYAC 312,1,2013Behavioral: Fluid intakeoral/rat lowest published toxic dose: 1433.04 mg/kg/7D- continuous TXCYAC 333,100,2015oral/rat lowest published toxic dose: 84.56 mg/kg/7D- continuous Kidney, Ureter, and Bladder: Other changes TXCYAC 325,21,2014oral/rat lowest published toxic dose: 332.92 mg/kg/7D- continuous Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder TXCYAC 325,21,2014Nutritional and Gross Metabolic: Weight loss or decreased weight gainoral/rat lowest published toxic dose: 1331.4 mg/kg/7D- continuous TXCYAC 325,21,2014Behavioral: Food intake (animal)Liver: Hepatitis (hepatocellular necrosis), diffuseoral/rat lowest published toxic dose: 61250 mg/kg/35W- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain IJEBA6 37,503,1999Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)oral/rat lowest published toxic dose: 52500 µg/kg/30D- continuous Liver: Changes in liver weight TXAPA9 36,76,1990Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesBlood: Methemoglobinemia- Carboxhemoglobinemiaoral/rat lowest published toxic dose: 13620 mg/kg/61W- continuous Blood: Changes in erythrocyte (RBC) count FCTOD7 31,285,1993Blood: Changes in leukocyte (WBC) countReviewsOrganization Standard ReferenceAmerican Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2013American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-Not classifiable as a human carcinogen DTLVS* TLV/BEI,2013TOXICOLOGY REVIEW CNDQA8 10(3),43,1975TOXICOLOGY REVIEW DTTIAF 80,485,1973TOXICOLOGY REVIEW MUTAEX 21,93,2006TOXICOLOGY REVIEW ENTOX* -,89,2005TOXICOLOGY REVIEW FEREAC 73,31788,2008TOXICOLOGY REVIEW FEREAC 72,32533,2007TOXICOLOGY REVIEW HUTOX* -,551,1996TOXICOLOGY REVIEW FEREAC 73,54954,2008TOXICOLOGY REVIEW TXAPA9 268,157,2013Standards and RegulationsOrganization Standard ReferenceEnvironmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES Supported RBREV* -,115,1998Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLVOccupational Exposure Limit-AUSTRALIA time-weighted average 10 mg/m3, JUL2008Occupational Exposure Limit-AUSTRIA MAK-TMW 5 mg/m3;KZW 10 mg/m3, inhal, 2007Occupational Exposure Limit-BELGIUM time-weighted average 10 mg/m3, MAR2002Occupational Exposure Limit-DENMARK time-weighted average 5 mg/m3, carc, MAY2011Occupational Exposure Limit-FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011Occupational Exposure Limit-FRANCE VME 10 mg/m3, C3 Carcinogen, FEB2006Occupational Exposure Limit-ICELAND time-weighted average 5 mg/m3, NOV2011Occupational Exposure Limit-KOREA time-weighted average 10 mg/m3, 2006Occupational Exposure Limit-MEXICO time-weighted average 10 mg/m3, 2004Occupational Exposure Limit-NEW ZEALAND time-weighted average 10 mg/m3, JAN2002Occupational Exposure Limit-NORWAY time-weighted average 5 mg/m3, JAN1999Occupational Exposure Limit-PERU time-weighted average 10 mg/m3, JUL2005Occupational Exposure Limit-SWITZERLAND MAK-week 10 mg/m3, carc 3, inhal, JAN2011Occupational Exposure Limit-THE NETHERLANDS MAC-TGG 10 mg/m3, 2003Occupational Exposure Limit-UNITED KINGDOM time-weighted average 10 mg/m3, OCT2007NIOSH Documentation and SurveillanceOrganization Standard ReferenceNational Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIURON-air 10H time-weighted average 10 mg/m3 NIOSH* DHHS #95-121,1995National Occupational Exposure Survey 1983 Hazard Code M0785; Number of Industries 8; Total Number of Facilities 75; Number of Occupations 12; Total Number of Employees Exposed 4216; Total Number of Female Employees Exposed 264National Occupational Hazard Survey 1974 Hazard Code M0785; Number of Industries 2; Total Number of Facilities 120; Number of Occupations 2; Total Number of Employees Exposed 374Status in Federal AgenciesOrganization ReferenceEPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversionEPA TSCA Section 8(b) CHEMICAL INVENTORYEPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001On EPA IRIS databasePage last reviewed: November 16, 2018Content source: National Institute for Occupational Safety and Health* SyndicateRegistry of Toxic Effects of Chemical Substances (RTECS)* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS DatabaseFollow NIOSH* YouTubeNIOSH Homepage* Workplace Safety & Health Topics* Publications and Products* Programs* Contact NIOSH* About CDC* Contact Us* 800-232-4636Facebook Twitter Instagram LinkedIn Youtube Pinterest SnapchatFacebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat RSS* CONTACT CDCContact UsCall 800-232-4636Email Us* ABOUT CDC+ About CDC+ Jobs+ Funding* POLICIES+ Accessibility+ External Links+ Privacy+ Policies+ Web Policies+ No Fear Act+ FOIA+ OIG+ No Fear Act+ Nondiscrimination+ Vulnerability Disclosure Policy+ CDC Archive+ Public Health Publications+ HHS.gov+ USA.gov* CONNECT WITH US+ Youtube+ Snapchat* LANGUAGES+ Español+ 繁體中文+ Tiếng Việt+ 한국어+ Tagalog+ Русский+ العربية+ Kreyòl Ayisyen+ Français+ Polski+ Português+ Italiano+ Deutsch+ 日本語+ فارسی+ English* U.S. Department of Health & Human Services* Accessibility* External Links* Privacy* Policies* Web Policies* FOIA* OIG* No Fear Act* FOIA* Nondiscrimination* OIG* Vulnerability Disclosure Policy* CDC Archive* Public Health Publications* HHS.gov* USA.govContent Credential×This image was edited or created using GenAI (generative artificial intelligence).Our experts review all images in an effort to ensure accuracy and quality before use.Learn more about CDC's usage of GenAI.Exit Notification/Disclaimer PolicyCloseLinks with this icon indicate that you are leaving the CDC 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