Comparison timestamp: 2025-05-05 18:35:49 UTC
RestoredCDC URL: http://restoredcdc.org/www.cdc.gov/niosh-rtecs/TQ14C080.html
Live cdc.gov URL ↗: https://www.cdc.gov/niosh-rtecs/TQ14C080.html
RestoredCDC URL: http://restoredcdc.org/www.cdc.gov/niosh-rtecs/TQ14C080.html
Live cdc.gov URL ↗: https://www.cdc.gov/niosh-rtecs/TQ14C080.html
Removed: Line removed from cdc.gov. Specific word removals are highlighted.
Added: Line added to cdc.gov. Specific word additions are highlighted.
Injected:
Line or disclaimer added by RestoredCDC.org.
Unchanged: Line unchanged.
Original site: www.cdc.gov/niosh-rtecs/TQ14C080.html | RestoredCDC.org is an independent project, not affiliated with CDC or any federal entity. Visit CDC.gov for free official information. Due to archival on January 6, 2025, recent outbreak data is unavailable. Videos are not restored. Access data.restoredcdc.org for restored data. Use of this site implies acceptance of this disclaimer.[More]About Us Report Bug Compare ContentSkip directly to page optionsThe National Institute for Occupational Safety and Health (NIOSH)Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting PeopleSearchSearch Menu Navigation Menu× NIOSHNIOSH All CDCSubmit* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS Database* The National Institute for Occupational Safety and Health (NIOSH) HomeThe National Institute for Occupational Safety and Health (NIOSH)1. Registry of Toxic Effects of Chemical Substances (RTECS)Polychlorinated biphenyl (aroclor 1254)Related PagesRTECS #TQ1360000CAS #11097-69-1See: NMAM or OSHA MethodsUpdatedSeptember 2018Molecular WeightN/RMolecular FormulaN/RSynonymsArochlor 1254Aroclor 1254Chlorierte biphenyle, chlorgehalt 54% (German)Chlorodiphenyl (54% chlorine)Chlorodiphenyl (54% chlorine) (ACGIH,OSHA)Chlorodiphenyl (54% Cl)Clorodifenili, cloro 54% (Italian)Diphenyle chlore, 54% de chlore (French)NCI-C02664PCB (OSHA)Mutation Data and ReferenceSystem Test Route/Organism/Tissue Dose ReferenceCytogenetic Analysis intraperitoneal/other fish 50 mg/kg CBPCEE 82,489,1985Cytogenetic Analysis embryo/chicken 1 mg/L/48H REPTED 19,79,2004DNA adduct liver/human 60 µmol/L/24H TXAPA9 188,81,2003DNA Damage oral/rat 1295 mg/kg BSIBAC 57,407,1981DNA Damage intraperitoneal/rat 500 mg/kg BSIBAC 57,407,1981DNA Damage liver/rat 300 µmol/L SinJF# 26OCT1982micronucleus test intraperitoneal/other fish 50 mg/kg CYTBAI 47,147,1986morphological transform oral/rat 25 ppm/2Y-continuous EVHPAZ 60,89,1985morphological transform fibroblast/mouse 5 mg/L/21D (-enzymatic activation step) EMMUEG 37,231,2001sperm morphology oral/other insects 808 mg CYTBAI 11,167,1974Unscheduled DNA Synthesis liver/rat 20 mg/L CNREA8 42,3010,1982Reproductive Effects Data and ReferencesRoute/Organism Dose Effect ReferenceReproductive: Other effects on femaleintraperitoneal/rat 250 mg/kg (15D pregnant) IJBOBV 25,1209,1993Reproductive: Effects on newborn: Biochemical and metabolicoral/mouse 59400 µg/kg (3D pre-21D after birth) Reproductive: Effects on newborn: Behavioral NTOTDY 3,5,1981Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)oral/rabbit 350 mg/kg (1-28D pregnant) Reproductive: Effects on fertility: Abortion EVPHBI 1,67,1971Reproductive: Effects on embryo or fetus: Fetal deathoral/rabbit 280 mg/kg (1-28D pregnant) Reproductive: Effects on newborn: Biochemical and metabolic BECTA6 6,120,1971oral/mammal (species unspecified) 14 mg/kg (30D prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) TOXID9 4,83,1984oral/rat 380 mg/kg (6-22D preg/21D after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 15,243,1995Reproductive: Specific developmental abnormalities: Central nervous systemoral/rat 38 mg/kg (6-22D preg/21D after birth) TOXID9 15,157,1995Reproductive: Specific developmental abnormalities: Endocrine systemReproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)oral/rat 152 mg/kg (6-22D preg/21D after birth) TOXID9 15,157,1995Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)oral/rat 38 mg/kg (6-22D preg/21D after birth) Reproductive: Specific developmental abnormalities: Eye, ear TOXID9 30,25,1996oral/rat 35 mg/kg (10-16D pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TXAPA9 136,269,1996Reproductive: Specific developmental abnormalities: Hepatobiliary systemoral/rat 320 µg/kg (5D after birth) ENVRAL 66,52,1994Reproductive: Specific developmental abnormalities: Urogenital systemoral/rat 160 µg/kg (5D after birth) Reproductive: Effects on newborn: Physical ENVRAL 66,52,1994oral/rat 222 mg/kg (6-22D preg/21D after birth) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 174,188,2001Reproductive: Specific developmental abnormalities: Hepatobiliary systemoral/rat 462.5 mg/kg (1D preg-15D after birth) Reproductive: Specific developmental abnormalities: Endocrine system BECTA6 48,715,1992Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)oral/rat 4 gm/kg (12-16D pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 21,62A,1980Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)oral/rat 192 mg/kg (6D after birth) Reproductive: Effects on newborn: Physical ENVRAL 31,76,1983Reproductive: Effects on newborn: Delayed effectsoral/rat 148 mg/kg (6-21D preg/21D after birth) Reproductive: Effects on newborn: Behavioral FAATDF 33,120,1996oral/rat 35 mg/kg (10-16D pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TXAPA9 139,252,1996oral/rat 90 mg/kg (7-15D pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system FCTXAV 11,471,1973oral/rat 40 mg/kg (5D after birth) Reproductive: Effects on newborn: Delayed effects BECTA6 38,946,1987oral/rat 750 mg/kg (5D male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) FCTXAV 13,507,1975oral/rat 96 mg/kg (6-21D pregnant) Reproductive: Effects on newborn: Behavioral BRREAP 850,87,1999oral/rat 304 mg/kg (6-22D preg/21D after birth) Reproductive: Effects on newborn: Other postnatal measures or effects HERED3 144,196,2000Reproductive: Effects on newborn: Behavioraloral/mouse 252 mg/kg (1-21D preg/21D after birth) Reproductive: Effects on newborn: Physical NRTXDN 23,375,2002Reproductive: Effects on newborn: Other postnatal measures or effectsReproductive: Specific developmental abnormalities: Gastrointestinal systemoral/rat 396 mg/kg (28D pre-16D after birth) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TOSCF2 77,315,2004Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)Reproductive: Specific developmental abnormalities: Eye, earoral/rat 228 mg/kg (6-22D preg/21D after birth) TOSCF2 68,458,2002Reproductive: Effects on newborn: Delayed effectsReproductive: Specific developmental abnormalities: Central nervous systemoral/mouse 222 mg/kg (6-21D preg/21D after birth) Reproductive: Effects on newborn: Behavioral NRTXDN 23,375,2002Reproductive: Effects on newborn: PhysicalReproductive: Other effects on femaleoral/rat 675 mg/kg (1-22D preg/23D after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOSCF2 77,51,2004Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)oral/mouse 90 mg/kg (6-20D pregnant) Reproductive: Effects on newborn: Behavioral ARTODN 80,286,2006Reproductive: Specific developmental abnormalities: Central nervous systemoral/rat 138 mg/kg (6-22D preg/7D after birth) TXAPA9 231,165,2008Reproductive: Effects on newborn: Biochemical and metabolicoral/rat 234 mg/kg (5D preg-21D after birth) Reproductive: Specific developmental abnormalities: Central nervous system NRTXDN 32,981,2011oral/rat 186 mg/kg (6D preg-14D after birth) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 256,290,2011Reproductive: Specific developmental abnormalities: Musculoskeletal systemoral/rat 675 mg/kg (1-22D preg/23D after birth) Reproductive: Effects on newborn: Other neonatal measures or effects TOLED5 207,82,2011Reproductive: Effects on newborn: Physicaloral/mouse 630 mg/kg (multigeneration) Reproductive: Effects on newborn: Behavioral FCTOD7 65,280,2014oral/rat 675 mg/kg (1D preg-23D after birth) Reproductive: Effects on newborn: Other postnatal measures or effects TOLED5 207,82,2011oral/rat 675 mg/kg (1D preg-23D after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOLED5 229,41,2014oral/rat 300 mg/kg (10-19D prior to copulation) Reproductive: Effects on newborn: Biochemical and metabolic NETOX* 47,37,2015Reproductive: Other effects on femaleoral/mouse 360 mg/kg (6-21D preg/21D after birth) Reproductive: Effects on newborn: Biochemical and metabolic NRTXDN 26,183,2005Reproductive: Effects on newborn: Behavioraloral/rat 125 mg/kg (15-19D pregnant) Reproductive: Specific developmental abnormalities: Central nervous system REPTED 20,521,2005Reproductive: Specific developmental abnormalities: Central nervous systemoral/rat 44 mg/kg (1-22D preg/21D after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 90,296,2006Reproductive: Effects on newborn: Behavioraloral/rat 138 mg/kg (6-21D preg/7D after birth) Reproductive: Effects on newborn: Biochemical and metabolic NETOX* 27,118,2006Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)oral/rat 396 mg/kg (28D pre-16D after birth) NETEEC 28,74,2006Reproductive: Effects on newborn: Biochemical and metabolicReproductive: Specific developmental abnormalities: Central nervous systemoral/rat 43 mg/kg (1D preg-21D after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 44,222,2005Reproductive: Effects on newborn: Behavioraloral/rat 14 mg/kg (2-15D pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 66,27,2002Reproductive: Effects on newborn: Biochemical and metabolicsubcutaneous/rat 90 mg/kg (10-18D pregnant) Reproductive: Effects on newborn: Physical TXCYAC 220,104,2006Reproductive: Effects on newborn: Other postnatal measures or effectssubcutaneous/rat 90 mg/kg (10-18D pregnant) Reproductive: Effects on newborn: Delayed effects TXCYAC 220,104,2006subcutaneous/rat 270 mg/kg (10-18D pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 72,133,2003Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemsubcutaneous/mouse 300 mg/kg (14D prior to copulation) Reproductive: Effects on newborn: Biochemical and metabolic AECTCV 44,72,2003Reproductive: Effects on newborn: Other postnatal measures or effectsReproductive: Specific developmental abnormalities: Central nervous systemsubcutaneous/rat 90 mg/kg (10-18D pregnant) TOLED5 135,S83,2001Reproductive: Specific developmental abnormalities: Endocrine systemReproductive: Specific developmental abnormalities: Central nervous systemunreported route/rat 144 mg/kg (6D preg-7D after birth) TOXID9 44,221,2005Reproductive: Effects on newborn: Biochemical and metabolicunreported route/rat 228 mg/kg (6D preg-21D after birth) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 66,27,2002Tumorigenic Data and ReferencesRoute/Organism Dose Effect ReferenceTumorigenic: Equivocal tumorigenic agent by RTECS criteriaintraperitoneal/mouse lowest published toxic dose: 500 mg/kg (19D pregnant) Reproductive: Tumorigenic effects: Transplacental tumorigenesis JJIND8 71,157,1983Lung, Thorax, or Respiration: TumorsTumorigenic: Neoplastic by RTECS criteriaoral/mouse lowest published toxic dose: 17 gm/kg/48W- continuous JNCIAM 53,547,1974Liver: TumorsTumorigenic: Carcinogenic by RTECS criteriaoral/rat lowest published toxic dose: 73500 mg/kg/2Y- continuous EVHPAZ 60,89,1985Liver: TumorsTumorigenic: Equivocal tumorigenic agent by RTECS criteriaoral/rat toxic dose: 1 mg/kg CNREA8 41,5052,1981Gastrointestinal: TumorsTumorigenic: Equivocal tumorigenic agent by RTECS criteriaoral/rat toxic dose: 3 mg/kg CNREA8 41,5052,1981Gastrointestinal: TumorsTumorigenic: Equivocal tumorigenic agent by RTECS criteriaoral/rat toxic dose: 4 gm/kg/2Y- intermittent Gastrointestinal: Tumors NCITR* NCI-TR-38,1978Liver: TumorsTumorigenic: Equivocal tumorigenic agent by RTECS criteriaskin/mouse lowest published toxic dose: 4 mg/kg Skin and Appendages: Tumors BECTA6 18,552,1977Tumorigenic: Tumors at site of applicationAcute Toxicity Data and ReferencesRoute/Organism Dose Effect ReferenceIn Vitro/ftb Inhibitor Concentration Low: 1 mg/L/60D In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. TIVIEQ 46,39,2018In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 25 µmol/L/48H In Vitro Toxicity Studies: Other assays FCTOD7 65,280,2014In Vitro/Mouse, fibroblast Inhibitor Concentration Low: 1 mg/L/60D In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. TIVIEQ 46,39,2018In Vitro/mqa Inhibitor Concentration Low: 1 µmol/L/20D In Vitro Toxicity Studies: Cell differentiation TIVIEQ 29,876,2015In Vitro/mqa Inhibitor Concentration (50 percent kill): 7.47 µmol/L In Vitro Toxicity Studies: Cell differentiation TIVIEQ 29,876,2015In Vitro/mqa Inhibitor Concentration Low: 5 mg/L/48H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TXCYAC 295,8,2012In Vitro Toxicity Studies: Apoptosis in vitroIn Vitro/mqa Inhibitor Concentration Low: 10 mg/L/24H TXCYAC 295,8,2012In Vitro Toxicity Studies: Other assaysIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.In Vitro/mtg Inhibitor Concentration Low: 60 µmol/L/24H In Vitro Toxicity Studies: Apoptosis in vitro TIVIEQ 28,373,2014In Vitro Toxicity Studies: Other assaysIn Vitro/paa Inhibitor Concentration Low: 1 mg/L/30M Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase TXAPA9 245,1,2010In Vitro/paa Inhibitor Concentration Low: 30 mg/L/5M Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase TXAPA9 245,1,2010intracerebral/rat lowest published toxic dose: 24 µg/kg Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum TXCYAC 216,140,2005intraperitoneal/mammal (species unspecified) lethal dose (50 percent kill): >1250 mg/kg AECTCV 6,279,1977intraperitoneal/mouse lethal dose (50 percent kill): 880 mg/kg BECTA6 8,245,1972Liver: Changes in liver weightintraperitoneal/mouse lowest published toxic dose: 50 mg/kg Endocrine: Other changes ENVPAF 72,57,1991Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)Liver: Other changesintraperitoneal/mouse lowest published toxic dose: 200 mg/kg ENVPAF 72,57,1991Blood: Other changesintraperitoneal/mouse lowest published toxic dose: 50 mg/kg Blood: Other changes ENVPAF 72,57,1991Endocrine: Other changesintraperitoneal/mouse lowest published toxic dose: 200 mg/kg ENVPAF 72,57,1991Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)Liver: Other changesintraperitoneal/mouse lowest published toxic dose: 500 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects TXAPA9 71,254,1983Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)Liver: Liver function tests impairedintraperitoneal/non-mammalian species lowest published toxic dose: 20 mg/kg Liver: Other changes TOLED5 136,97,2002Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesKidney, Ureter, and Bladder: Other changesintraperitoneal/non-mammalian species lowest published toxic dose: 70 mg/kg TOLED5 136,97,2002Biochemical: Metabolism (intermediary): Other proteinsintraperitoneal/rat lowest published toxic dose: 500 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) MOPMA3 13,924,1977intraperitoneal/rat lowest published toxic dose: 10 mg/kg Endocrine: Evidence of thyroid hypofunction ATSUDG 13,440,1989Kidney, Ureter, and Bladder: Other changesintravenous/chicken lowest published toxic dose: 300 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) JBCHA3 255,8275,1980Biochemical: Metabolism (intermediary): Effect on mitochondrial functionintravenous/rat lethal dose (50 percent kill): 358 mg/kg VCVGK* -,58,1984Behavioral: Somnolence (general depressed activity)intravenous/rat lethal dose (50 percent kill): 358 mg/kg Lung, Thorax, or Respiration: Dyspnea FCTXAV 12,63,1974Gastrointestinal: Hypermotility, diarrheaoral/mammal (species unspecified) lethal dose (50 percent kill): 4 gm/kg AECTCV 6,279,1977oral/rat lethal dose (50 percent kill): 1010 mg/kg TXAPA9 60,33,1981Liver: Other changesoral/rat lowest published toxic dose: 300 mg/kg Endocrine: Evidence of thyroid hypofunction EVHPAZ 109,1163,2001Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsBrain and Coverings: Other degenerative changesoral/rat lowest published toxic dose: 330 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases ARTODN 78,316,2004Biochemical: Metabolism (intermediary): OtherTank with water/Zebrafish lowest published toxic concentration: 2 ppm/24H Behavioral: Alteration of classical conditioning NRTXDN 53,93,2016Other Multiple Dose Data and ReferencesRoute/Organism Dose Effect Referenceintramuscular/domestic animal lowest published toxic dose: 5 mg/kg/20D- intermittent Liver: Other changes JEPOEC 12,17,1993intramuscular/domestic animal lowest published toxic dose: 7500 µg/kg/12W- intermittent Liver: Other changes JEPOEC 12,17,1993intramuscular/rabbit lowest published toxic dose: 25 mg/kg/20D- intermittent Liver: Other changes JEPOEC 12,17,1993Endocrine: Other changesintraperitoneal/guinea pig lowest published toxic dose: 320 mg/kg/13D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) CBCPAI 99C,251,1991Biochemical: Metabolism (intermediary): OtherEndocrine: Other changesintraperitoneal/non-mammalian species lowest published toxic dose: 320 mg/kg/13D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) CBCPAI 99C,251,1991Biochemical: Metabolism (intermediary): OtherLiver: Changes in liver weightintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 44,2040,2006Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesEndocrine: Change in LHintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Endocrine: Change in gonadotropins TXCYAC 232,170,2007Reproductive: Paternal effects: Testes, epididymis, sperm ductBrain and Coverings: Changes in brain weightintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NRTXDN 28,490,2007Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsMusculoskeletal: Other changesintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 241,99,2007Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 23,239,2007Brain and Coverings: Other degenerative changesintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase BCLPT* 105,92,2009Biochemical: Metabolism (intermediary): Lipids including transportReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)intraperitoneal/rat lowest published toxic dose: 30 mg/kg/20D- intermittent Biochemical: Metabolism (intermediary): Effect on mitochondrial function FCTOD7 47,1733,2009Related to Chronic Data: Changes in testicular weightEndocrine: Other changesintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases REPTED 27,41,2009Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesBrain and Coverings: Other degenerative changesintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Behavioral: Change in psychophysiological tests TOLED5 222,45,2013Blood: Other changesintraperitoneal/rat lowest published toxic dose: 50 mg/kg/2W- intermittent Biochemical: Metabolism (intermediary): Other BECTA6 19,729,1978Reproductive: Paternal effects: Testes, epididymis, sperm ductintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 19,201,2004Related to Chronic Data: Changes in testicular weightReproductive: Paternal effects: Testes, epididymis, sperm ductintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent REPTED 19,201,2004Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: CatalasesEndocrine: Androgenicintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct REPTED 20,117,2005Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsintraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases REPTED 20,117,2005Liver: Other changesintraperitoneal/rat lowest published toxic dose: 350 mg/kg/7D- intermittent Liver: Changes in liver weight JTEHD6 4,107,1978Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesEndocrine: Other changesintraperitoneal/wild bird lowest published toxic dose: 320 mg/kg/13D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) CBCPAI 99C,251,1991Biochemical: Metabolism (intermediary): OtherAutonomic Nervous System: Sympathomimeticoral/domestic bird lowest published toxic dose: 431 mg/kg/8W- continuous Liver: Changes in liver weight TXAPA9 53,75,1980Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sitesNutritional and Gross Metabolic: Weight loss or decreased weight gainoral/mammal (species unspecified) lowest published toxic dose: 119 mg/kg/28D- continuous AECTCV 15,393,1986Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldCardiac: Changes in heart weightoral/mammal (species unspecified) lowest published toxic dose: 180 mg/kg/17W- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain AECTCV 6,279,1977Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldoral/monkey lowest published toxic dose: 8365 µg/kg/4.5Y- intermittent Immunological Including Allergic: Decrease in humoral immune response FAATDF 16,773,1991Eye: Other eye effectsoral/monkey lowest published toxic dose: 170 mg/kg/2.3Y- intermittent Blood: Changes in spleen TOPADD 14,1,1986Skin and Appendages: Other: Nailsoral/monkey lowest published toxic dose: 14.6 mg/kg/2Y- intermittent Endocrine: Other changes AECTCV 19,939,1990oral/monkey lowest published toxic dose: 58.4 mg/kg/2Y- intermittent Endocrine: Effect on menstrual cycle AECTCV 19,939,1990oral/mouse lowest published toxic dose: 672 mg/kg/28D- continuous Liver: Changes in liver weight JTEHD6 5,605,1979Behavioral: Altered sleep time (including change in righting reflex)oral/mouse lowest published toxic dose: 90 mg/kg/15D- continuous Liver: Changes in liver weight TXAPA9 40,91,1977Endocrine: Changes in adrenal weightBehavioral: Altered sleep time (including change in righting reflex)oral/mouse lowest published toxic dose: 168 mg/kg/2W- continuous ENPBBC 5,308,1975Liver: Changes in liver weightReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)oral/mouse lowest published toxic dose: 672 mg/kg/2W- continuous ENPBBC 5,308,1975Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsoral/mouse lowest published toxic dose: 178 mg/kg/14D- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain BECTA6 12,394,1974Behavioral: Altered sleep time (including change in righting reflex)oral/mouse lowest published toxic dose: 552 mg/kg/14D- continuous BECTA6 12,394,1974Liver: Changes in liver weightoral/mouse lowest published toxic dose: 1965 mg/kg/14D- continuous Endocrine: Changes in adrenal weight BECTA6 12,394,1974oral/mouse lowest published toxic dose: 3360 mg/kg/7D- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BECTA6 12,394,1974Liver: Changes in liver weightoral/mouse lowest published toxic dose: 75.6 mg/kg/21D- intermittent Endocrine: Evidence of thyroid hypofunction TXAPA9 188,6,2003Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesEndocrine: Estrogenicoral/mouse lowest published toxic dose: 8500 µg/kg/50D- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXCYAC 287,21,2011Reproductive: Paternal effects: Testes, epididymis, sperm ductoral/mouse lowest published toxic dose: 8.5 µg/kg/50D- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 287,21,2011Brain and Coverings: Other degenerative changesoral/non-mammalian species lowest published toxic dose: 30 mg/kg/30D- continuous BIREBV 64,955,2001Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesBrain and Coverings: Other degenerative changesoral/non-mammalian species lowest published toxic dose: 30 mg/kg/15D- continuous BIREBV 64,955,2001Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesEndocrine: Androgenicoral/non-mammalian species lowest published toxic dose: 102.9 mg/kg/30D- continuous Endocrine: Estrogenic MAERE* 24,179,1988Related to Chronic Data: Changes in ovarian weightLiver: Other changesoral/quail lowest published toxic dose: 588 mg/kg/12W- intermittent JTEHD6 51,57,1997Biochemical: Metabolism (intermediary): Porphyrin including bile pigmentsLiver: Changes in liver weightoral/rabbit lowest published toxic dose: 4200 mg/kg/14W- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases AJPAA4 70,363,1973Related to Chronic Data: Changes in uterine weightoral/rabbit lowest published toxic dose: 5.94 mg/kg/33D- continuous Immunological Including Allergic: Decrease in humoral immune response TXAPA9 32,587,1975oral/rabbit lowest published toxic dose: 10.26 mg/kg/57D- continuous Endocrine: Other changes TXAPA9 32,587,1975Liver: Changes in liver weightoral/rabbit lowest published toxic dose: 119.7 mg/kg/57D- continuous TXAPA9 32,587,1975Endocrine: Changes in spleen weightoral/rat lowest published toxic dose: 10 mg/kg/40D- continuous Endocrine: Evidence of thyroid hypofunction ENDOAO 121,520,1987oral/rat lowest published toxic dose: 10 mg/kg/20D- continuous Endocrine: Evidence of thyroid hypofunction ENDOAO 121,520,1987oral/rat lowest published toxic dose: 7.5 mg/kg/150D- continuous Biochemical: Metabolism (intermediary): Other ENDOAO 121,520,1987oral/rat lowest published toxic dose: 8.4 mg/kg/4W- continuous Endocrine: Evidence of thyroid hyperfunction VAAZA2 33,213,1980oral/rat lowest published toxic dose: 84 mg/kg/4W- continuous Endocrine: Toxic goiter- hypofunction VAAZA2 33,213,1980oral/rat lowest published toxic dose: 10.5 mg/kg/5W- continuous Endocrine: Other changes JEPTDQ 1,587,1978Liver: Tumorsoral/rat lowest published toxic dose: 756 mg/kg/18W- continuous JNCIAM 66,509,1981Tumorigenic: Facilitates action of known carcinogensLiver: Changes in liver weightoral/rat lowest published toxic dose: 350 mg/kg/7D- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct EXMPA6 22,376,1975Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphatasesLiver: Changes in liver weightoral/rat lowest published toxic dose: 165 mg/kg/11D- intermittent CJPPA3 54,23,1976Biochemical: Metabolism (intermediary): OtherLiver: Changes in liver weightoral/rat lowest published toxic dose: 21 mg/kg/7D- continuous Endocrine: Evidence of thyroid hyperfunction ATSUDG 12,85,1988Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatasesoral/rat lowest published toxic dose: 63 mg/kg/7D- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases ATSUDG 12,85,1988Liver: Fatty liver degenerationoral/rat lowest published toxic dose: 33.6 mg/kg/28D- continuous Endocrine: Other changes JTEHD6 6,421,1980Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)Endocrine: Evidence of thyroid hypofunctionoral/rat lowest published toxic dose: 42 mg/kg/7D- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 72,313,2003Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesLiver: Other changesoral/rat lowest published toxic dose: 21 mg/kg/7D- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 44,420,2005Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesBiochemical: Metabolism (intermediary): Lipids including transportoral/rat lowest published toxic dose: 21 mg/kg/7D- continuous TOXID9 44,420,2005Biochemical: Metabolism (intermediary): OtherLiver: Fatty liver degenerationoral/rat lowest published toxic dose: 120 mg/kg/4D- intermittent Endocrine: Hypoglycemia TOXID9 78,245,2004Biochemical: Metabolism (intermediary): OtherLiver: Other changesoral/rat lowest published toxic dose: 180 mg/kg/3D- intermittent Endocrine: Differential effect of sex or castration on observed toxicity TOXID9 78,246,2004Biochemical: Metabolism (intermediary): Other proteinsBehavioral: Change in motor activity (specific assay)oral/rat lowest published toxic dose: 600 mg/kg/4W- intermittent FAATDF 40,68,1997Nutritional and Gross Metabolic: Weight loss or decreased weight gainLiver: Other changesoral/rat lowest published toxic dose: 5475 mg/kg/52W- continuous Biochemical: Metabolism (intermediary): Lipids including transport AECTCV 8,191,1979Biochemical: Metabolism (intermediary): Other proteinsLiver: Other changesoral/rat lowest published toxic dose: 1652 mg/kg/35W- continuous AEHLAU 25,354,1972Liver: Changes in liver weightLiver: Changes in liver weightoral/rat lowest published toxic dose: 210 mg/kg/20W- continuous TXAPA9 37,112,1976Biochemical: Metabolism (intermediary): Lipids including transportLiver: Changes in liver weightoral/rat lowest published toxic dose: 105 mg/kg/15W- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight TXCYAC 57,83,1989Musculoskeletal: Other changesLiver: Other changesoral/rat lowest published toxic dose: 50400 µg/kg/12W- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) BECTA6 12,669,1974Biochemical: Metabolism (intermediary): Other proteinsLiver: Changes in liver weightoral/rat lowest published toxic dose: 60 mg/kg/20D- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) JTEHD6 3,769,1977Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)Liver: Changes in liver weightoral/rat lowest published toxic dose: 70 mg/kg/1W- intermittent BECTA6 12,145,1974Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)Liver: Changes in liver weightoral/rat lowest published toxic dose: 1920 µg/kg/4D- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) BECTA6 34,427,1985Biochemical: Metabolism (intermediary): Lipids including transportBlood: Changes in bone marrow not included in aboveoral/rat lowest published toxic dose: 750 mg/kg/5D- intermittent BECTA6 13,14,1975Nutritional and Gross Metabolic: Weight loss or decreased weight gainoral/rat lowest published toxic dose: 1500 mg/kg/5D- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BECTA6 13,14,1975Behavioral: Food intake (animal)oral/rat lowest published toxic dose: 1820 mg/kg/52W- continuous TOSCF2 53,377,2000Nutritional and Gross Metabolic: Weight loss or decreased weight gainEndocrine: Changes in pituitary weightoral/rat lowest published toxic dose: 1750 mg/kg/10W- intermittent FAATDF 20,288,1993Nutritional and Gross Metabolic: Weight loss or decreased weight gainEndocrine: Changes in pituitary weightoral/rat lowest published toxic dose: 2625 mg/kg/15W- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) FAATDF 20,288,1993Nutritional and Gross Metabolic: Weight loss or decreased weight gainLiver: Other changesoral/rat lowest published toxic dose: 35 mg/kg/5W- intermittent Kidney, Ureter, and Bladder: Other changes FAATDF 20,288,1993Endocrine: Evidence of thyroid hypofunctionEndocrine: Effect on menstrual cycleoral/rat lowest published toxic dose: 300 mg/kg/30D- intermittent CBCPAI 77C ,65,1984Nutritional and Gross Metabolic: Weight loss or decreased weight gainoral/rat lowest published toxic dose: 632.4 mg/kg/372D- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 53,377,2000oral/rat lowest published toxic dose: 1055.6 mg/kg/182D- continuous Musculoskeletal: Other changes TOSCF2 53,377,2000oral/rat lowest published toxic dose: 309.4 mg/kg/182D- continuous Behavioral: Change in motor activity (specific assay) TOSCF2 53,377,2000Liver: Jaundice, other or unclassifiedoral/rat lowest published toxic dose: 3500 mg/kg/5W- intermittent TOXID9 66,283,2002Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldBlood: Other changesoral/rat lowest published toxic dose: 350 mg/kg/5W- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 66,283,2002Biochemical: Metabolism (intermediary): Porphyrin including bile pigmentsoral/rat lowest published toxic dose: 224 mg/kg/7D- intermittent Endocrine: Other changes TOXID9 60,380,2001Brain and Coverings: Other degenerative changesoral/rat lowest published toxic dose: 600 mg/kg/6D- intermittent TOLED5 161,152,2006Biochemical: Metabolism (intermediary): Other proteinsLiver: Other changesoral/rat lowest published toxic dose: 1.8 mg/kg/3D- intermittent Endocrine: Other changes TOXID9 -,167,2008Biochemical: Metabolism (intermediary): Other proteinsBrain and Coverings: Other degenerative changesoral/rat lowest published toxic dose: 600 mg/kg/6D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 161,152,2006Biochemical: Metabolism (intermediary): Other proteinsBrain and Coverings: Other degenerative changesoral/rat lowest published toxic dose: 140 mg/kg/2W- intermittent TXCYAC 300,12,2012Biochemical: Metabolism (intermediary): Effect on active transportEndocrine: Evidence of thyroid hypofunctionoral/rat lowest published toxic dose: 56 mg/kg/14D- intermittent TXCYAC 177,227,2002Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsLiver: Changes in liver weightoral/rat lowest published toxic dose: 42 mg/kg/7D- intermittent TOSCF2 65,184,2002Endocrine: Evidence of thyroid hypofunctionoral/rat lowest published toxic dose: 700 mg/kg/28D- intermittent Biochemical: Metabolism (intermediary): Other TOLED5 225,240,2014Liver: Other changesoral/rat lowest published toxic dose: 675 mg/kg/45D- intermittent TOLED5 229,41,2014Biochemical: Metabolism (intermediary): Otheroral/rat lowest published toxic dose: 140 mg/kg/14D- intermittent Brain and Coverings: Other degenerative changes NRTXDN 33,16,2012Liver: Other changesoral/rat lowest published toxic dose: 42 mg/kg/7D- continuous TXAPA9 248,38,2010Endocrine: Other changesoral/rat lowest published toxic dose: 42 mg/kg/7D- continuous Endocrine: Other changes TXAPA9 248,38,2010Liver: Other changesoral/rat lowest published toxic dose: 60 mg/kg/6D- intermittent Liver: Changes in liver weight TXAPA9 248,178,2010Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)Liver: Other changesoral/rat lowest published toxic dose: 26.25 mg/kg/7D- intermittent MUREAV 746,144,2012Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsoral/wild bird lowest published toxic dose: 2800 mg/kg/8W- intermittent Endocrine: Changes in thyroid weight BECTA6 8,306,1972parenteral/duck lowest published toxic dose: 25 mg/kg/10W- intermittent Liver: Other changes JEPOEC 12,17,1993Liver: Changes in liver weightskin/rat lowest published toxic dose: 120 µg/kg/4D- intermittent CJPPA3 54,23,1976Biochemical: Metabolism (intermediary): OtherImmunological Including Allergic: Decrease in humoral immune responsesubcutaneous/domestic animal lowest published toxic dose: 20 mg/kg/20D- intermittent JEPOEC 9,283,1989Nutritional and Gross Metabolic: Weight loss or decreased weight gainLung, Thorax, or Respiration: Other changessubcutaneous/rabbit lowest published toxic dose: 25 mg/kg/20D- intermittent Kidney, Ureter, and Bladder: Other changes JEPOEC 9,283,1989Biochemical: Metabolism (intermediary): Other proteinsEndocrine: Other changessubcutaneous/rat lowest published toxic dose: 170 mg/kg/5W- intermittent TOLED5 166,276,2006Musculoskeletal: Other changessubcutaneous/rat lowest published toxic dose: 210 mg/kg/6W- intermittent Nutritional and Gross Metabolic: Changes in: Ca TOLED5 166,276,2006Liver: Other changesunreported route/rat lowest published toxic dose: 210 mg/kg/21D- intermittent TOXID9 66,303,2002Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesReviewsOrganization Standard ReferenceAmerican Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-time-weighted average 0.5 mg/m3 (skin) DTLVS* TLV/BEI,2013American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-Confirmed animal carcinogen DTLVS* TLV/BEI,2013International Agency for Research on Cancer (IARC) Cancer Review:Human Limited Evidence IMEMDT 18,43,1978International Agency for Research on Cancer (IARC) Cancer Review:Animal Sufficient Evidence IMSUDL 7,322,1987International Agency for Research on Cancer (IARC) Cancer Review:Group 2A IMSUDL 7,322,1987TOXICOLOGY REVIEW EVHPAZ 1,105,1972TOXICOLOGY REVIEW ARVPAX 14,139,1974TOXICOLOGY REVIEW RREVAH 44,1,1973TOXICOLOGY REVIEW STEVA8 2,305,1974TOXICOLOGY REVIEW BISNAS 20,958,1970TOXICOLOGY REVIEW ENVRAL 5,249,1972TOXICOLOGY REVIEW ARTODN 78,252,2004TOXICOLOGY REVIEW NETEEC 28,260,2006TOXICOLOGY REVIEW ENTOX* -,334,2005TOXICOLOGY REVIEW TIHEEC 16,305,2000TOXICOLOGY REVIEW ITODC* -,327,2004TOXICOLOGY REVIEW FCTOD7 46,813,2008TOXICOLOGY REVIEW MUREAV 681,80,2009TOXICOLOGY REVIEW NTAPM* -,347,1995TOXICOLOGY REVIEW NRTXDN 33,178,2012TOXICOLOGY REVIEW NETOX* 33,911,2012TOXICOLOGY REVIEW MUTAEX 30,89,2014TOXICOLOGY REVIEW MUTAEX 25,17,2010TOXICOLOGY REVIEW NETEEC 36,3,2013TOXICOLOGY REVIEW NETEEC 52,68,2015TOXICOLOGY REVIEW FCTOD7 106,609,2017TOXICOLOGY REVIEW FCTOD7 108,365,2017Standards and RegulationsOrganization Standard ReferenceMine Safety and Health Administration (MSHA) STANDARD-air time-weighted average 0.5 mg/m3 (skin) DTLVS* 3,52,1971Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLVOccupational Exposure Limit-AUSTRALIA time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, Carcinogen, JUL2008Occupational Exposure Limit-AUSTRIA MAK-TMW 0.05 ppm (0.5 mg/m3);KZW 0.5 ppm (5 mg/m3), skin, 2007Occupational Exposure Limit-BELGIUM time-weighted average 0.5 mg/m3, Skin, MAR2002Occupational Exposure Limit-FRANCE VME 0.5 mg/m3, Skin, FEB2006Occupational Exposure Limit-GERMANY MAK 0.05 ppm (0.7 mg/m3), skin, 2011Occupational Exposure Limit-KOREA time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, skin, 2006Occupational Exposure Limit-MEXICO time-weighted average 0.5 mg/m3;short term exposure limit 1 mg/m3 (skin), 2004Occupational Exposure Limit-NORWAY time-weighted average 0.01 mg/m3, JAN1999Occupational Exposure Limit-PERU time-weighted average 0.04 ppm (0.5 mg/m3), JUL2005Occupational Exposure Limit-POLAND MAC(time-weighted average) 1 mg/m3, JAN1999Occupational Exposure Limit-SWEDEN time-weighted average 0.01 mg/m3;short term exposure limit 0.03 mg/m3, Carcinogen, Skin, JUN2005Occupational Exposure Limit-SWITZERLAND MAK-week 0.05 ppm (0.5 mg/m3), KZG-week 0.4 ppm (4 mg/m3), carc 3, skin, JAN2011Occupational Exposure Limit-THE NETHERLANDS MAC-TGG 0.5 mg/m3, Skin, 2003Occupational Exposure Limit-TURKEY time-weighted average 1 mg/m3, Skin, JAN1993Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8H time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1926.55,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8H time-weighted average 0.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8H time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8H time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993NIOSH Documentation and SurveillanceOrganization Standard ReferenceNational Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORODIPHENYL (54% Cl)-air 10H Carcinogen time-weighted average 0.001 mg/m3 NIOSH* DHHS #92-100,1992National Occupational Exposure Survey 1983 Hazard Code X1181; Number of Industries 5; Total Number of Facilities 170; Number of Occupations 7; Total Number of Employees Exposed 3702; Total Number of Female Employees Exposed 1725Status in Federal AgenciesOrganization ReferenceATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108027)EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleusEPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Rodent dominant lethalEPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouseEPA TSCA Section 8(d) unpublished health/safety studiesEPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat NCITR* NCI-TR-38,1978NIOSH Analytical Method, 1994: Polychlorobiphenyls, 5503; in serum, 8004NIOSH CURRENT INTELLIGENCE BULLETIN 7, 1976 AND BULLETIN 45, 1986NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogenOn EPA IRIS databasePage last reviewed: November 16, 2018Content source: National Institute for Occupational Safety and Health* SyndicateRegistry of Toxic Effects of Chemical Substances (RTECS)* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS DatabaseFollow NIOSH* YouTubeNIOSH Homepage* Workplace Safety & Health Topics* Publications and Products* Programs* Contact NIOSH* About CDC* Contact Us* 800-232-4636Facebook Twitter Instagram LinkedIn Youtube Pinterest SnapchatFacebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat RSS* CONTACT CDCContact UsCall 800-232-4636Email Us* ABOUT CDC+ About CDC+ Jobs+ Funding* POLICIES+ Accessibility+ External Links+ Privacy+ Policies+ Web Policies+ No Fear Act+ FOIA+ OIG+ No Fear Act+ Nondiscrimination+ Vulnerability Disclosure Policy+ CDC Archive+ Public Health Publications+ HHS.gov+ USA.gov* CONNECT WITH US+ Youtube+ Snapchat* LANGUAGES+ Español+ 繁體中文+ Tiếng Việt+ 한국어+ Tagalog+ Русский+ العربية+ Kreyòl Ayisyen+ Français+ Polski+ Português+ Italiano+ Deutsch+ 日本語+ فارسی+ English* U.S. Department of Health & Human Services* Accessibility* External Links* Privacy* Policies* Web Policies* FOIA* OIG* No Fear Act* FOIA* Nondiscrimination* OIG* Vulnerability Disclosure Policy* CDC Archive* Public Health Publications* HHS.gov* USA.govContent Credential×This image was edited or created using GenAI (generative artificial intelligence).Our experts review all images in an effort to ensure accuracy and quality before use.Learn more about CDC's usage of GenAI.Exit Notification/Disclaimer PolicyCloseLinks with this icon indicate that you are leaving the CDC website.* The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.* Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.* You will be subject to the destination website's privacy policy when you follow the link.* CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.For more information on CDC's web notification policies, see Website Disclaimers.Cancel Continue
Note: Comparison ignores leading/trailing whitespace
and certain script/tracking codes. Word-level
highlighting (optional above) only applies to changed
lines.