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1. Registry of Toxic Effects of Chemical Substances (RTECS)
Polychlorinated biphenyl (aroclor 1254)
Related Pages
RTECS #
TQ1360000
CAS #
11097-69-1
See: NMAM or OSHA Methods
Updated
September 2018
Molecular Weight
N/R
Molecular Formula
N/R
Synonyms
Arochlor 1254
Aroclor 1254
Chlorierte biphenyle, chlorgehalt 54% (German)
Chlorodiphenyl (54% chlorine)
Chlorodiphenyl (54% chlorine) (ACGIH,OSHA)
Chlorodiphenyl (54% Cl)
Clorodifenili, cloro 54% (Italian)
Diphenyle chlore, 54% de chlore (French)
NCI-C02664
PCB (OSHA)
Mutation Data and Reference
System Test Route/Organism/Tissue Dose Reference
Cytogenetic Analysis intraperitoneal/other fish 50 mg/kg CBPCEE 82,489,1985
Cytogenetic Analysis embryo/chicken 1 mg/L/48H REPTED 19,79,2004
DNA adduct liver/human 60 µmol/L/24H TXAPA9 188,81,2003
DNA Damage oral/rat 1295 mg/kg BSIBAC 57,407,1981
DNA Damage intraperitoneal/rat 500 mg/kg BSIBAC 57,407,1981
DNA Damage liver/rat 300 µmol/L SinJF# 26OCT1982
micronucleus test intraperitoneal/other fish 50 mg/kg CYTBAI 47,147,1986
morphological transform oral/rat 25 ppm/2Y-continuous EVHPAZ 60,89,1985
morphological transform fibroblast/mouse 5 mg/L/21D (-enzymatic activation step) EMMUEG 37,231,2001
sperm morphology oral/other insects 808 mg CYTBAI 11,167,1974
Unscheduled DNA Synthesis liver/rat 20 mg/L CNREA8 42,3010,1982
Reproductive Effects Data and References
Route/Organism Dose Effect Reference
Reproductive: Other effects on female
intraperitoneal/rat 250 mg/kg (15D pregnant) IJBOBV 25,1209,1993
Reproductive: Effects on newborn: Biochemical and metabolic
oral/mouse 59400 µg/kg (3D pre-21D after birth) Reproductive: Effects on newborn: Behavioral NTOTDY 3,5,1981
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
oral/rabbit 350 mg/kg (1-28D pregnant) Reproductive: Effects on fertility: Abortion EVPHBI 1,67,1971
Reproductive: Effects on embryo or fetus: Fetal death
oral/rabbit 280 mg/kg (1-28D pregnant) Reproductive: Effects on newborn: Biochemical and metabolic BECTA6 6,120,1971
oral/mammal (species unspecified) 14 mg/kg (30D prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) TOXID9 4,83,1984
oral/rat 380 mg/kg (6-22D preg/21D after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 15,243,1995
Reproductive: Specific developmental abnormalities: Central nervous system
oral/rat 38 mg/kg (6-22D preg/21D after birth) TOXID9 15,157,1995
Reproductive: Specific developmental abnormalities: Endocrine system
Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
oral/rat 152 mg/kg (6-22D preg/21D after birth) TOXID9 15,157,1995
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
oral/rat 38 mg/kg (6-22D preg/21D after birth) Reproductive: Specific developmental abnormalities: Eye, ear TOXID9 30,25,1996
oral/rat 35 mg/kg (10-16D pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TXAPA9 136,269,1996
Reproductive: Specific developmental abnormalities: Hepatobiliary system
oral/rat 320 µg/kg (5D after birth) ENVRAL 66,52,1994
Reproductive: Specific developmental abnormalities: Urogenital system
oral/rat 160 µg/kg (5D after birth) Reproductive: Effects on newborn: Physical ENVRAL 66,52,1994
oral/rat 222 mg/kg (6-22D preg/21D after birth) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 174,188,2001
Reproductive: Specific developmental abnormalities: Hepatobiliary system
oral/rat 462.5 mg/kg (1D preg-15D after birth) Reproductive: Specific developmental abnormalities: Endocrine system BECTA6 48,715,1992
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
oral/rat 4 gm/kg (12-16D pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 21,62A,1980
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
oral/rat 192 mg/kg (6D after birth) Reproductive: Effects on newborn: Physical ENVRAL 31,76,1983
Reproductive: Effects on newborn: Delayed effects
oral/rat 148 mg/kg (6-21D preg/21D after birth) Reproductive: Effects on newborn: Behavioral FAATDF 33,120,1996
oral/rat 35 mg/kg (10-16D pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TXAPA9 139,252,1996
oral/rat 90 mg/kg (7-15D pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system FCTXAV 11,471,1973
oral/rat 40 mg/kg (5D after birth) Reproductive: Effects on newborn: Delayed effects BECTA6 38,946,1987
oral/rat 750 mg/kg (5D male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) FCTXAV 13,507,1975
oral/rat 96 mg/kg (6-21D pregnant) Reproductive: Effects on newborn: Behavioral BRREAP 850,87,1999
oral/rat 304 mg/kg (6-22D preg/21D after birth) Reproductive: Effects on newborn: Other postnatal measures or effects HERED3 144,196,2000
Reproductive: Effects on newborn: Behavioral
oral/mouse 252 mg/kg (1-21D preg/21D after birth) Reproductive: Effects on newborn: Physical NRTXDN 23,375,2002
Reproductive: Effects on newborn: Other postnatal measures or effects
Reproductive: Specific developmental abnormalities: Gastrointestinal system
oral/rat 396 mg/kg (28D pre-16D after birth) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TOSCF2 77,315,2004
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
Reproductive: Specific developmental abnormalities: Eye, ear
oral/rat 228 mg/kg (6-22D preg/21D after birth) TOSCF2 68,458,2002
Reproductive: Effects on newborn: Delayed effects
Reproductive: Specific developmental abnormalities: Central nervous system
oral/mouse 222 mg/kg (6-21D preg/21D after birth) Reproductive: Effects on newborn: Behavioral NRTXDN 23,375,2002
Reproductive: Effects on newborn: Physical
Reproductive: Other effects on female
oral/rat 675 mg/kg (1-22D preg/23D after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOSCF2 77,51,2004
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
oral/mouse 90 mg/kg (6-20D pregnant) Reproductive: Effects on newborn: Behavioral ARTODN 80,286,2006
Reproductive: Specific developmental abnormalities: Central nervous system
oral/rat 138 mg/kg (6-22D preg/7D after birth) TXAPA9 231,165,2008
Reproductive: Effects on newborn: Biochemical and metabolic
oral/rat 234 mg/kg (5D preg-21D after birth) Reproductive: Specific developmental abnormalities: Central nervous system NRTXDN 32,981,2011
oral/rat 186 mg/kg (6D preg-14D after birth) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 256,290,2011
Reproductive: Specific developmental abnormalities: Musculoskeletal system
oral/rat 675 mg/kg (1-22D preg/23D after birth) Reproductive: Effects on newborn: Other neonatal measures or effects TOLED5 207,82,2011
Reproductive: Effects on newborn: Physical
oral/mouse 630 mg/kg (multigeneration) Reproductive: Effects on newborn: Behavioral FCTOD7 65,280,2014
oral/rat 675 mg/kg (1D preg-23D after birth) Reproductive: Effects on newborn: Other postnatal measures or effects TOLED5 207,82,2011
oral/rat 675 mg/kg (1D preg-23D after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOLED5 229,41,2014
oral/rat 300 mg/kg (10-19D prior to copulation) Reproductive: Effects on newborn: Biochemical and metabolic NETOX* 47,37,2015
Reproductive: Other effects on female
oral/mouse 360 mg/kg (6-21D preg/21D after birth) Reproductive: Effects on newborn: Biochemical and metabolic NRTXDN 26,183,2005
Reproductive: Effects on newborn: Behavioral
oral/rat 125 mg/kg (15-19D pregnant) Reproductive: Specific developmental abnormalities: Central nervous system REPTED 20,521,2005
Reproductive: Specific developmental abnormalities: Central nervous system
oral/rat 44 mg/kg (1-22D preg/21D after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 90,296,2006
Reproductive: Effects on newborn: Behavioral
oral/rat 138 mg/kg (6-21D preg/7D after birth) Reproductive: Effects on newborn: Biochemical and metabolic NETOX* 27,118,2006
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
oral/rat 396 mg/kg (28D pre-16D after birth) NETEEC 28,74,2006
Reproductive: Effects on newborn: Biochemical and metabolic
Reproductive: Specific developmental abnormalities: Central nervous system
oral/rat 43 mg/kg (1D preg-21D after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 44,222,2005
Reproductive: Effects on newborn: Behavioral
oral/rat 14 mg/kg (2-15D pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 66,27,2002
Reproductive: Effects on newborn: Biochemical and metabolic
subcutaneous/rat 90 mg/kg (10-18D pregnant) Reproductive: Effects on newborn: Physical TXCYAC 220,104,2006
Reproductive: Effects on newborn: Other postnatal measures or effects
subcutaneous/rat 90 mg/kg (10-18D pregnant) Reproductive: Effects on newborn: Delayed effects TXCYAC 220,104,2006
subcutaneous/rat 270 mg/kg (10-18D pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 72,133,2003
Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system
subcutaneous/mouse 300 mg/kg (14D prior to copulation) Reproductive: Effects on newborn: Biochemical and metabolic AECTCV 44,72,2003
Reproductive: Effects on newborn: Other postnatal measures or effects
Reproductive: Specific developmental abnormalities: Central nervous system
subcutaneous/rat 90 mg/kg (10-18D pregnant) TOLED5 135,S83,2001
Reproductive: Specific developmental abnormalities: Endocrine system
Reproductive: Specific developmental abnormalities: Central nervous system
unreported route/rat 144 mg/kg (6D preg-7D after birth) TOXID9 44,221,2005
Reproductive: Effects on newborn: Biochemical and metabolic
unreported route/rat 228 mg/kg (6D preg-21D after birth) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 66,27,2002
Tumorigenic Data and References
Route/Organism Dose Effect Reference
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria
intraperitoneal/mouse lowest published toxic dose: 500 mg/kg (19D pregnant) Reproductive: Tumorigenic effects: Transplacental tumorigenesis JJIND8 71,157,1983
Lung, Thorax, or Respiration: Tumors
Tumorigenic: Neoplastic by RTECS criteria
oral/mouse lowest published toxic dose: 17 gm/kg/48W- continuous JNCIAM 53,547,1974
Liver: Tumors
Tumorigenic: Carcinogenic by RTECS criteria
oral/rat lowest published toxic dose: 73500 mg/kg/2Y- continuous EVHPAZ 60,89,1985
Liver: Tumors
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria
oral/rat toxic dose: 1 mg/kg CNREA8 41,5052,1981
Gastrointestinal: Tumors
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria
oral/rat toxic dose: 3 mg/kg CNREA8 41,5052,1981
Gastrointestinal: Tumors
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria
oral/rat toxic dose: 4 gm/kg/2Y- intermittent Gastrointestinal: Tumors NCITR* NCI-TR-38,1978
Liver: Tumors
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria
skin/mouse lowest published toxic dose: 4 mg/kg Skin and Appendages: Tumors BECTA6 18,552,1977
Tumorigenic: Tumors at site of application
Acute Toxicity Data and References
Route/Organism Dose Effect Reference
In Vitro/ftb Inhibitor Concentration Low: 1 mg/L/60D In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. TIVIEQ 46,39,2018
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 25 µmol/L/48H In Vitro Toxicity Studies: Other assays FCTOD7 65,280,2014
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: 1 mg/L/60D In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. TIVIEQ 46,39,2018
In Vitro/mqa Inhibitor Concentration Low: 1 µmol/L/20D In Vitro Toxicity Studies: Cell differentiation TIVIEQ 29,876,2015
In Vitro/mqa Inhibitor Concentration (50 percent kill): 7.47 µmol/L In Vitro Toxicity Studies: Cell differentiation TIVIEQ 29,876,2015
In Vitro/mqa Inhibitor Concentration Low: 5 mg/L/48H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TXCYAC 295,8,2012
In Vitro Toxicity Studies: Apoptosis in vitro
In Vitro/mqa Inhibitor Concentration Low: 10 mg/L/24H TXCYAC 295,8,2012
In Vitro Toxicity Studies: Other assays
In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
In Vitro/mtg Inhibitor Concentration Low: 60 µmol/L/24H In Vitro Toxicity Studies: Apoptosis in vitro TIVIEQ 28,373,2014
In Vitro Toxicity Studies: Other assays
In Vitro/paa Inhibitor Concentration Low: 1 mg/L/30M Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase TXAPA9 245,1,2010
In Vitro/paa Inhibitor Concentration Low: 30 mg/L/5M Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase TXAPA9 245,1,2010
intracerebral/rat lowest published toxic dose: 24 µg/kg Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum TXCYAC 216,140,2005
intraperitoneal/mammal (species unspecified) lethal dose (50 percent kill): >1250 mg/kg AECTCV 6,279,1977
intraperitoneal/mouse lethal dose (50 percent kill): 880 mg/kg BECTA6 8,245,1972
Liver: Changes in liver weight
intraperitoneal/mouse lowest published toxic dose: 50 mg/kg Endocrine: Other changes ENVPAF 72,57,1991
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Liver: Other changes
intraperitoneal/mouse lowest published toxic dose: 200 mg/kg ENVPAF 72,57,1991
Blood: Other changes
intraperitoneal/mouse lowest published toxic dose: 50 mg/kg Blood: Other changes ENVPAF 72,57,1991
Endocrine: Other changes
intraperitoneal/mouse lowest published toxic dose: 200 mg/kg ENVPAF 72,57,1991
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Liver: Other changes
intraperitoneal/mouse lowest published toxic dose: 500 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects TXAPA9 71,254,1983
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Liver: Liver function tests impaired
intraperitoneal/non-mammalian species lowest published toxic dose: 20 mg/kg Liver: Other changes TOLED5 136,97,2002
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
Kidney, Ureter, and Bladder: Other changes
intraperitoneal/non-mammalian species lowest published toxic dose: 70 mg/kg TOLED5 136,97,2002
Biochemical: Metabolism (intermediary): Other proteins
intraperitoneal/rat lowest published toxic dose: 500 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) MOPMA3 13,924,1977
intraperitoneal/rat lowest published toxic dose: 10 mg/kg Endocrine: Evidence of thyroid hypofunction ATSUDG 13,440,1989
Kidney, Ureter, and Bladder: Other changes
intravenous/chicken lowest published toxic dose: 300 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) JBCHA3 255,8275,1980
Biochemical: Metabolism (intermediary): Effect on mitochondrial function
intravenous/rat lethal dose (50 percent kill): 358 mg/kg VCVGK* -,58,1984
Behavioral: Somnolence (general depressed activity)
intravenous/rat lethal dose (50 percent kill): 358 mg/kg Lung, Thorax, or Respiration: Dyspnea FCTXAV 12,63,1974
Gastrointestinal: Hypermotility, diarrhea
oral/mammal (species unspecified) lethal dose (50 percent kill): 4 gm/kg AECTCV 6,279,1977
oral/rat lethal dose (50 percent kill): 1010 mg/kg TXAPA9 60,33,1981
Liver: Other changes
oral/rat lowest published toxic dose: 300 mg/kg Endocrine: Evidence of thyroid hypofunction EVHPAZ 109,1163,2001
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
Brain and Coverings: Other degenerative changes
oral/rat lowest published toxic dose: 330 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases ARTODN 78,316,2004
Biochemical: Metabolism (intermediary): Other
Tank with water/Zebrafish lowest published toxic concentration: 2 ppm/24H Behavioral: Alteration of classical conditioning NRTXDN 53,93,2016
Other Multiple Dose Data and References
Route/Organism Dose Effect Reference
intramuscular/domestic animal lowest published toxic dose: 5 mg/kg/20D- intermittent Liver: Other changes JEPOEC 12,17,1993
intramuscular/domestic animal lowest published toxic dose: 7500 µg/kg/12W- intermittent Liver: Other changes JEPOEC 12,17,1993
intramuscular/rabbit lowest published toxic dose: 25 mg/kg/20D- intermittent Liver: Other changes JEPOEC 12,17,1993
Endocrine: Other changes
intraperitoneal/guinea pig lowest published toxic dose: 320 mg/kg/13D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) CBCPAI 99C,251,1991
Biochemical: Metabolism (intermediary): Other
Endocrine: Other changes
intraperitoneal/non-mammalian species lowest published toxic dose: 320 mg/kg/13D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) CBCPAI 99C,251,1991
Biochemical: Metabolism (intermediary): Other
Liver: Changes in liver weight
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 44,2040,2006
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
Endocrine: Change in LH
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Endocrine: Change in gonadotropins TXCYAC 232,170,2007
Reproductive: Paternal effects: Testes, epididymis, sperm duct
Brain and Coverings: Changes in brain weight
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NRTXDN 28,490,2007
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
Musculoskeletal: Other changes
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 241,99,2007
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 23,239,2007
Brain and Coverings: Other degenerative changes
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase BCLPT* 105,92,2009
Biochemical: Metabolism (intermediary): Lipids including transport
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
intraperitoneal/rat lowest published toxic dose: 30 mg/kg/20D- intermittent Biochemical: Metabolism (intermediary): Effect on mitochondrial function FCTOD7 47,1733,2009
Related to Chronic Data: Changes in testicular weight
Endocrine: Other changes
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases REPTED 27,41,2009
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
Brain and Coverings: Other degenerative changes
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Behavioral: Change in psychophysiological tests TOLED5 222,45,2013
Blood: Other changes
intraperitoneal/rat lowest published toxic dose: 50 mg/kg/2W- intermittent Biochemical: Metabolism (intermediary): Other BECTA6 19,729,1978
Reproductive: Paternal effects: Testes, epididymis, sperm duct
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 19,201,2004
Related to Chronic Data: Changes in testicular weight
Reproductive: Paternal effects: Testes, epididymis, sperm duct
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent REPTED 19,201,2004
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
Endocrine: Androgenic
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct REPTED 20,117,2005
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases REPTED 20,117,2005
Liver: Other changes
intraperitoneal/rat lowest published toxic dose: 350 mg/kg/7D- intermittent Liver: Changes in liver weight JTEHD6 4,107,1978
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
Endocrine: Other changes
intraperitoneal/wild bird lowest published toxic dose: 320 mg/kg/13D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) CBCPAI 99C,251,1991
Biochemical: Metabolism (intermediary): Other
Autonomic Nervous System: Sympathomimetic
oral/domestic bird lowest published toxic dose: 431 mg/kg/8W- continuous Liver: Changes in liver weight TXAPA9 53,75,1980
Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
oral/mammal (species unspecified) lowest published toxic dose: 119 mg/kg/28D- continuous AECTCV 15,393,1986
Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
Cardiac: Changes in heart weight
oral/mammal (species unspecified) lowest published toxic dose: 180 mg/kg/17W- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain AECTCV 6,279,1977
Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
oral/monkey lowest published toxic dose: 8365 µg/kg/4.5Y- intermittent Immunological Including Allergic: Decrease in humoral immune response FAATDF 16,773,1991
Eye: Other eye effects
oral/monkey lowest published toxic dose: 170 mg/kg/2.3Y- intermittent Blood: Changes in spleen TOPADD 14,1,1986
Skin and Appendages: Other: Nails
oral/monkey lowest published toxic dose: 14.6 mg/kg/2Y- intermittent Endocrine: Other changes AECTCV 19,939,1990
oral/monkey lowest published toxic dose: 58.4 mg/kg/2Y- intermittent Endocrine: Effect on menstrual cycle AECTCV 19,939,1990
oral/mouse lowest published toxic dose: 672 mg/kg/28D- continuous Liver: Changes in liver weight JTEHD6 5,605,1979
Behavioral: Altered sleep time (including change in righting reflex)
oral/mouse lowest published toxic dose: 90 mg/kg/15D- continuous Liver: Changes in liver weight TXAPA9 40,91,1977
Endocrine: Changes in adrenal weight
Behavioral: Altered sleep time (including change in righting reflex)
oral/mouse lowest published toxic dose: 168 mg/kg/2W- continuous ENPBBC 5,308,1975
Liver: Changes in liver weight
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
oral/mouse lowest published toxic dose: 672 mg/kg/2W- continuous ENPBBC 5,308,1975
Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
oral/mouse lowest published toxic dose: 178 mg/kg/14D- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain BECTA6 12,394,1974
Behavioral: Altered sleep time (including change in righting reflex)
oral/mouse lowest published toxic dose: 552 mg/kg/14D- continuous BECTA6 12,394,1974
Liver: Changes in liver weight
oral/mouse lowest published toxic dose: 1965 mg/kg/14D- continuous Endocrine: Changes in adrenal weight BECTA6 12,394,1974
oral/mouse lowest published toxic dose: 3360 mg/kg/7D- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BECTA6 12,394,1974
Liver: Changes in liver weight
oral/mouse lowest published toxic dose: 75.6 mg/kg/21D- intermittent Endocrine: Evidence of thyroid hypofunction TXAPA9 188,6,2003
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
Endocrine: Estrogenic
oral/mouse lowest published toxic dose: 8500 µg/kg/50D- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXCYAC 287,21,2011
Reproductive: Paternal effects: Testes, epididymis, sperm duct
oral/mouse lowest published toxic dose: 8.5 µg/kg/50D- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 287,21,2011
Brain and Coverings: Other degenerative changes
oral/non-mammalian species lowest published toxic dose: 30 mg/kg/30D- continuous BIREBV 64,955,2001
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
Brain and Coverings: Other degenerative changes
oral/non-mammalian species lowest published toxic dose: 30 mg/kg/15D- continuous BIREBV 64,955,2001
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
Endocrine: Androgenic
oral/non-mammalian species lowest published toxic dose: 102.9 mg/kg/30D- continuous Endocrine: Estrogenic MAERE* 24,179,1988
Related to Chronic Data: Changes in ovarian weight
Liver: Other changes
oral/quail lowest published toxic dose: 588 mg/kg/12W- intermittent JTEHD6 51,57,1997
Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
Liver: Changes in liver weight
oral/rabbit lowest published toxic dose: 4200 mg/kg/14W- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases AJPAA4 70,363,1973
Related to Chronic Data: Changes in uterine weight
oral/rabbit lowest published toxic dose: 5.94 mg/kg/33D- continuous Immunological Including Allergic: Decrease in humoral immune response TXAPA9 32,587,1975
oral/rabbit lowest published toxic dose: 10.26 mg/kg/57D- continuous Endocrine: Other changes TXAPA9 32,587,1975
Liver: Changes in liver weight
oral/rabbit lowest published toxic dose: 119.7 mg/kg/57D- continuous TXAPA9 32,587,1975
Endocrine: Changes in spleen weight
oral/rat lowest published toxic dose: 10 mg/kg/40D- continuous Endocrine: Evidence of thyroid hypofunction ENDOAO 121,520,1987
oral/rat lowest published toxic dose: 10 mg/kg/20D- continuous Endocrine: Evidence of thyroid hypofunction ENDOAO 121,520,1987
oral/rat lowest published toxic dose: 7.5 mg/kg/150D- continuous Biochemical: Metabolism (intermediary): Other ENDOAO 121,520,1987
oral/rat lowest published toxic dose: 8.4 mg/kg/4W- continuous Endocrine: Evidence of thyroid hyperfunction VAAZA2 33,213,1980
oral/rat lowest published toxic dose: 84 mg/kg/4W- continuous Endocrine: Toxic goiter- hypofunction VAAZA2 33,213,1980
oral/rat lowest published toxic dose: 10.5 mg/kg/5W- continuous Endocrine: Other changes JEPTDQ 1,587,1978
Liver: Tumors
oral/rat lowest published toxic dose: 756 mg/kg/18W- continuous JNCIAM 66,509,1981
Tumorigenic: Facilitates action of known carcinogens
Liver: Changes in liver weight
oral/rat lowest published toxic dose: 350 mg/kg/7D- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct EXMPA6 22,376,1975
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
Liver: Changes in liver weight
oral/rat lowest published toxic dose: 165 mg/kg/11D- intermittent CJPPA3 54,23,1976
Biochemical: Metabolism (intermediary): Other
Liver: Changes in liver weight
oral/rat lowest published toxic dose: 21 mg/kg/7D- continuous Endocrine: Evidence of thyroid hyperfunction ATSUDG 12,85,1988
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
oral/rat lowest published toxic dose: 63 mg/kg/7D- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases ATSUDG 12,85,1988
Liver: Fatty liver degeneration
oral/rat lowest published toxic dose: 33.6 mg/kg/28D- continuous Endocrine: Other changes JTEHD6 6,421,1980
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Endocrine: Evidence of thyroid hypofunction
oral/rat lowest published toxic dose: 42 mg/kg/7D- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 72,313,2003
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
Liver: Other changes
oral/rat lowest published toxic dose: 21 mg/kg/7D- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 44,420,2005
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
Biochemical: Metabolism (intermediary): Lipids including transport
oral/rat lowest published toxic dose: 21 mg/kg/7D- continuous TOXID9 44,420,2005
Biochemical: Metabolism (intermediary): Other
Liver: Fatty liver degeneration
oral/rat lowest published toxic dose: 120 mg/kg/4D- intermittent Endocrine: Hypoglycemia TOXID9 78,245,2004
Biochemical: Metabolism (intermediary): Other
Liver: Other changes
oral/rat lowest published toxic dose: 180 mg/kg/3D- intermittent Endocrine: Differential effect of sex or castration on observed toxicity TOXID9 78,246,2004
Biochemical: Metabolism (intermediary): Other proteins
Behavioral: Change in motor activity (specific assay)
oral/rat lowest published toxic dose: 600 mg/kg/4W- intermittent FAATDF 40,68,1997
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
Liver: Other changes
oral/rat lowest published toxic dose: 5475 mg/kg/52W- continuous Biochemical: Metabolism (intermediary): Lipids including transport AECTCV 8,191,1979
Biochemical: Metabolism (intermediary): Other proteins
Liver: Other changes
oral/rat lowest published toxic dose: 1652 mg/kg/35W- continuous AEHLAU 25,354,1972
Liver: Changes in liver weight
Liver: Changes in liver weight
oral/rat lowest published toxic dose: 210 mg/kg/20W- continuous TXAPA9 37,112,1976
Biochemical: Metabolism (intermediary): Lipids including transport
Liver: Changes in liver weight
oral/rat lowest published toxic dose: 105 mg/kg/15W- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight TXCYAC 57,83,1989
Musculoskeletal: Other changes
Liver: Other changes
oral/rat lowest published toxic dose: 50400 µg/kg/12W- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) BECTA6 12,669,1974
Biochemical: Metabolism (intermediary): Other proteins
Liver: Changes in liver weight
oral/rat lowest published toxic dose: 60 mg/kg/20D- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) JTEHD6 3,769,1977
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Liver: Changes in liver weight
oral/rat lowest published toxic dose: 70 mg/kg/1W- intermittent BECTA6 12,145,1974
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
Liver: Changes in liver weight
oral/rat lowest published toxic dose: 1920 µg/kg/4D- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) BECTA6 34,427,1985
Biochemical: Metabolism (intermediary): Lipids including transport
Blood: Changes in bone marrow not included in above
oral/rat lowest published toxic dose: 750 mg/kg/5D- intermittent BECTA6 13,14,1975
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
oral/rat lowest published toxic dose: 1500 mg/kg/5D- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BECTA6 13,14,1975
Behavioral: Food intake (animal)
oral/rat lowest published toxic dose: 1820 mg/kg/52W- continuous TOSCF2 53,377,2000
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
Endocrine: Changes in pituitary weight
oral/rat lowest published toxic dose: 1750 mg/kg/10W- intermittent FAATDF 20,288,1993
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
Endocrine: Changes in pituitary weight
oral/rat lowest published toxic dose: 2625 mg/kg/15W- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) FAATDF 20,288,1993
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
Liver: Other changes
oral/rat lowest published toxic dose: 35 mg/kg/5W- intermittent Kidney, Ureter, and Bladder: Other changes FAATDF 20,288,1993
Endocrine: Evidence of thyroid hypofunction
Endocrine: Effect on menstrual cycle
oral/rat lowest published toxic dose: 300 mg/kg/30D- intermittent CBCPAI 77C ,65,1984
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
oral/rat lowest published toxic dose: 632.4 mg/kg/372D- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 53,377,2000
oral/rat lowest published toxic dose: 1055.6 mg/kg/182D- continuous Musculoskeletal: Other changes TOSCF2 53,377,2000
oral/rat lowest published toxic dose: 309.4 mg/kg/182D- continuous Behavioral: Change in motor activity (specific assay) TOSCF2 53,377,2000
Liver: Jaundice, other or unclassified
oral/rat lowest published toxic dose: 3500 mg/kg/5W- intermittent TOXID9 66,283,2002
Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
Blood: Other changes
oral/rat lowest published toxic dose: 350 mg/kg/5W- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 66,283,2002
Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
oral/rat lowest published toxic dose: 224 mg/kg/7D- intermittent Endocrine: Other changes TOXID9 60,380,2001
Brain and Coverings: Other degenerative changes
oral/rat lowest published toxic dose: 600 mg/kg/6D- intermittent TOLED5 161,152,2006
Biochemical: Metabolism (intermediary): Other proteins
Liver: Other changes
oral/rat lowest published toxic dose: 1.8 mg/kg/3D- intermittent Endocrine: Other changes TOXID9 -,167,2008
Biochemical: Metabolism (intermediary): Other proteins
Brain and Coverings: Other degenerative changes
oral/rat lowest published toxic dose: 600 mg/kg/6D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 161,152,2006
Biochemical: Metabolism (intermediary): Other proteins
Brain and Coverings: Other degenerative changes
oral/rat lowest published toxic dose: 140 mg/kg/2W- intermittent TXCYAC 300,12,2012
Biochemical: Metabolism (intermediary): Effect on active transport
Endocrine: Evidence of thyroid hypofunction
oral/rat lowest published toxic dose: 56 mg/kg/14D- intermittent TXCYAC 177,227,2002
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
Liver: Changes in liver weight
oral/rat lowest published toxic dose: 42 mg/kg/7D- intermittent TOSCF2 65,184,2002
Endocrine: Evidence of thyroid hypofunction
oral/rat lowest published toxic dose: 700 mg/kg/28D- intermittent Biochemical: Metabolism (intermediary): Other TOLED5 225,240,2014
Liver: Other changes
oral/rat lowest published toxic dose: 675 mg/kg/45D- intermittent TOLED5 229,41,2014
Biochemical: Metabolism (intermediary): Other
oral/rat lowest published toxic dose: 140 mg/kg/14D- intermittent Brain and Coverings: Other degenerative changes NRTXDN 33,16,2012
Liver: Other changes
oral/rat lowest published toxic dose: 42 mg/kg/7D- continuous TXAPA9 248,38,2010
Endocrine: Other changes
oral/rat lowest published toxic dose: 42 mg/kg/7D- continuous Endocrine: Other changes TXAPA9 248,38,2010
Liver: Other changes
oral/rat lowest published toxic dose: 60 mg/kg/6D- intermittent Liver: Changes in liver weight TXAPA9 248,178,2010
Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
Liver: Other changes
oral/rat lowest published toxic dose: 26.25 mg/kg/7D- intermittent MUREAV 746,144,2012
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
oral/wild bird lowest published toxic dose: 2800 mg/kg/8W- intermittent Endocrine: Changes in thyroid weight BECTA6 8,306,1972
parenteral/duck lowest published toxic dose: 25 mg/kg/10W- intermittent Liver: Other changes JEPOEC 12,17,1993
Liver: Changes in liver weight
skin/rat lowest published toxic dose: 120 µg/kg/4D- intermittent CJPPA3 54,23,1976
Biochemical: Metabolism (intermediary): Other
Immunological Including Allergic: Decrease in humoral immune response
subcutaneous/domestic animal lowest published toxic dose: 20 mg/kg/20D- intermittent JEPOEC 9,283,1989
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
Lung, Thorax, or Respiration: Other changes
subcutaneous/rabbit lowest published toxic dose: 25 mg/kg/20D- intermittent Kidney, Ureter, and Bladder: Other changes JEPOEC 9,283,1989
Biochemical: Metabolism (intermediary): Other proteins
Endocrine: Other changes
subcutaneous/rat lowest published toxic dose: 170 mg/kg/5W- intermittent TOLED5 166,276,2006
Musculoskeletal: Other changes
subcutaneous/rat lowest published toxic dose: 210 mg/kg/6W- intermittent Nutritional and Gross Metabolic: Changes in: Ca TOLED5 166,276,2006
Liver: Other changes
unreported route/rat lowest published toxic dose: 210 mg/kg/21D- intermittent TOXID9 66,303,2002
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
Reviews
Organization Standard Reference
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-time-weighted average 0.5 mg/m3 (skin) DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-Confirmed animal carcinogen DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC) Cancer Review:Human Limited Evidence IMEMDT 18,43,1978
International Agency for Research on Cancer (IARC) Cancer Review:Animal Sufficient Evidence IMSUDL 7,322,1987
International Agency for Research on Cancer (IARC) Cancer Review:Group 2A IMSUDL 7,322,1987
TOXICOLOGY REVIEW EVHPAZ 1,105,1972
TOXICOLOGY REVIEW ARVPAX 14,139,1974
TOXICOLOGY REVIEW RREVAH 44,1,1973
TOXICOLOGY REVIEW STEVA8 2,305,1974
TOXICOLOGY REVIEW BISNAS 20,958,1970
TOXICOLOGY REVIEW ENVRAL 5,249,1972
TOXICOLOGY REVIEW ARTODN 78,252,2004
TOXICOLOGY REVIEW NETEEC 28,260,2006
TOXICOLOGY REVIEW ENTOX* -,334,2005
TOXICOLOGY REVIEW TIHEEC 16,305,2000
TOXICOLOGY REVIEW ITODC* -,327,2004
TOXICOLOGY REVIEW FCTOD7 46,813,2008
TOXICOLOGY REVIEW MUREAV 681,80,2009
TOXICOLOGY REVIEW NTAPM* -,347,1995
TOXICOLOGY REVIEW NRTXDN 33,178,2012
TOXICOLOGY REVIEW NETOX* 33,911,2012
TOXICOLOGY REVIEW MUTAEX 30,89,2014
TOXICOLOGY REVIEW MUTAEX 25,17,2010
TOXICOLOGY REVIEW NETEEC 36,3,2013
TOXICOLOGY REVIEW NETEEC 52,68,2015
TOXICOLOGY REVIEW FCTOD7 106,609,2017
TOXICOLOGY REVIEW FCTOD7 108,365,2017
Standards and Regulations
Organization Standard Reference
Mine Safety and Health Administration (MSHA) STANDARD-air time-weighted average 0.5 mg/m3 (skin) DTLVS* 3,52,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIA MAK-TMW 0.05 ppm (0.5 mg/m3);KZW 0.5 ppm (5 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUM time-weighted average 0.5 mg/m3, Skin, MAR2002
Occupational Exposure Limit-FRANCE VME 0.5 mg/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANY MAK 0.05 ppm (0.7 mg/m3), skin, 2011
Occupational Exposure Limit-KOREA time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICO time-weighted average 0.5 mg/m3;short term exposure limit 1 mg/m3 (skin), 2004
Occupational Exposure Limit-NORWAY time-weighted average 0.01 mg/m3, JAN1999
Occupational Exposure Limit-PERU time-weighted average 0.04 ppm (0.5 mg/m3), JUL2005
Occupational Exposure Limit-POLAND MAC(time-weighted average) 1 mg/m3, JAN1999
Occupational Exposure Limit-SWEDEN time-weighted average 0.01 mg/m3;short term exposure limit 0.03 mg/m3, Carcinogen, Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND MAK-week 0.05 ppm (0.5 mg/m3), KZG-week 0.4 ppm (4 mg/m3), carc 3, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS MAC-TGG 0.5 mg/m3, Skin, 2003
Occupational Exposure Limit-TURKEY time-weighted average 1 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8H time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8H time-weighted average 0.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8H time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8H time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
NIOSH Documentation and Surveillance
Organization Standard Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORODIPHENYL (54% Cl)-air 10H Carcinogen time-weighted average 0.001 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 Hazard Code X1181; Number of Industries 5; Total Number of Facilities 170; Number of Occupations 7; Total Number of Employees Exposed 3702; Total Number of Female Employees Exposed 1725
Status in Federal Agencies
Organization Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108027)
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat NCITR* NCI-TR-38,1978
NIOSH Analytical Method, 1994: Polychlorobiphenyls, 5503; in serum, 8004
NIOSH CURRENT INTELLIGENCE BULLETIN 7, 1976 AND BULLETIN 45, 1986
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
On EPA IRIS database
Page last reviewed: November 16, 2018
Content source: National Institute for Occupational Safety and Health
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