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        The National Institute for Occupational Safety and Health (NIOSH)
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          The National Institute for Occupational Safety and Health (NIOSH)
         1. Registry of Toxic Effects of Chemical Substances (RTECS)
      Plumbane, tetramethyl-
            Related Pages
                RTECS #
                  TP4725000
                CAS #
                  75-74-1
                  See: NMAM or OSHA Methods
                Updated
                  March 2018
                Molecular Weight
                  267.35
                Molecular Formula
                  C4H12Pb
                Synonyms
                  Lead, tetramethyl-
                  Piombo tetra-metile (Italian)
                  Tetramethyl lead
                  Tetramethyl lead (ACGIH:OSHA)
                  Tetramethylolovo (Czech)
                  Tetramethylplumbane
                  TML
        Reproductive Effects Data and References
          Route/Organism  Dose                        Effect                                                                                                                               Reference         
                                                      Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)                    
          oral/rat        112 mg/kg (9-11D pregnant)                                                                                                                                       TXAPA9 21,265,1972
                                                      Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)                                                             
          oral/rat        80 mg/kg (9-11D pregnant)   Reproductive: Specific developmental abnormalities: Musculoskeletal system                                                           TXAPA9 21,265,1972
          Acute Toxicity Data and References
            Route/Organism       Dose                                                    Effect                                                                 Reference         
            inhalation/mouse     lethal concentration (50 percent kill): 8500 mg/m3/30M                                                                         85JCAE -,1258,1986
            inhalation/rat       Lethal concentration: >9840 mg/m3/1H                                                                                           BJIMAG 18,277,1961
            intraperitoneal/rat  lethal dose (50 percent kill): 90 mg/kg                                                                                        MELAAD 54,486,1963
                                                                                         Eye: Other eye effects                                                                   
            intravenous/rabbit   lowest published lethal dose: 90 mg/kg                  Behavioral: Muscle weakness                                            JPETAB 38,161,1930
                                                                                         Nutritional and Gross Metabolic: Weight loss or decreased weight gain                    
            intravenous/rat      lethal dose (50 percent kill): 88 mg/kg                                                                                        MELAAD 54,486,1963
            oral/guinea pig      lethal dose (50 percent kill): 109 mg/kg                                                                                       YAKUD5 22,455,1980
            oral/rabbit          lowest published lethal dose: 24 mg/kg                                                                                         SAIGBL 15,3,1973  
            oral/rat             lethal dose (50 percent kill): 105 mg/kg                                                                                       MELAAD 54,486,1963
            parenteral/rat       lethal dose (50 percent kill): 105 mg/kg                                                                                       AOHYA3 3,226,1961 
            skin/rabbit          lowest published lethal dose: 3391 mg/kg                                                                                       SAIGBL 15,3,1973  
            Other Multiple Dose Data and References
              Route/Organism      Dose                                                                 Effect                                                           Reference          
                                                                                                       Brain and Coverings: Other degenerative changes                                     
              inhalation/rat      lowest published toxic concentration: 900 mg/m3/1H/5D- intermittent  Behavioral: Irritability                                         NTIS** OTS0533656-1
                                                                                                       Lung, Thorax, or Respiration: Other changes                                         
              intravenous/monkey  lowest published toxic dose: 42 mg/kg/7D- intermittent               Kidney, Ureter, and Bladder: Other changes in urine composition  TOLED5 2,187,1978  
              Reviews
                Organization                                                       Standard                                                           Reference          
                American Conference of Governmental Industrial Hygienists (ACGIH)  Threshold Limit Value-time-weighted average 0.15 mg(Pb)/m3 (skin)  DTLVS* TLV/BEI,2013
                TOXICOLOGY REVIEW                                                                                                                     85DHAX Pb,255,1972 
                TOXICOLOGY REVIEW                                                                                                                     MUREAV 770,119,2016
                Standards and Regulations
                  Organization                                                                                           Standard                                                                                        Reference               
                  Mine Safety and Health Administration (MSHA) STANDARD-air                                              time-weighted average 0.15 mg(Pb)/m3 (skin)                                                     DTLVS* 3,253,1971       
                  Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;                                                                                                                                          
                  Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV                                                                                                                                                              
                  Occupational Exposure Limit-ARAB Republic of Egypt                                                     time-weighted average 0.05 mg(Pb)/m3, JAN1993                                                                           
                  Occupational Exposure Limit-AUSTRALIA                                                                  time-weighted average 0.15 mg(Pb)/m3, JUL2008                                                                           
                  Occupational Exposure Limit-AUSTRIA                                                                    MAK-TMW 0.05 mg/m3;KZW 0.2 mg/m3, skin, 2007                                                                            
                  Occupational Exposure Limit-BELGIUM                                                                    time-weighted average 0.15 mg(Pb)/m3, Skin, MAR2002                                                                     
                  Occupational Exposure Limit-DENMARK                                                                    time-weighted average 0.007 ppm (0.05 mg(Pb)/m3), skin, MAY2011                                                         
                  Occupational Exposure Limit-FINLAND                                                                    time-weighted average 0.075 mg(Pb)/m3, short term exposure limit 0.23 mg(Pb)/m3, skin, NOV2011                          
                  Occupational Exposure Limit-FRANCE                                                                     VME 0.15 mg(Pb)/m3, Skin, FEB2006                                                                                       
                  Occupational Exposure Limit-GERMANY                                                                    MAK 0.05 mg(Pb)/m3, skin, 2011                                                                                          
                  Occupational Exposure Limit-HUNGARY                                                                    time-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, Skin, SEP2000                                    
                  Occupational Exposure Limit-ICELAND                                                                    time-weighted average 0.05 mg/m3, skin, NOV2011                                                                         
                  Occupational Exposure Limit-KOREA                                                                      time-weighted average 0.075 mg/m3, skin, 2006                                                                           
                  Occupational Exposure Limit-MEXICO                                                                     time-weighted average 0.15 mg(Pb)/m3;short term exposure limit 0.5 mg(Pb)/m3 (skin), 2004                               
                  Occupational Exposure Limit-NEW ZEALAND                                                                time-weighted average 0.15 mg(Pb)/m3, skin, JAN2002                                                                     
                  Occupational Exposure Limit-NORWAY                                                                     time-weighted average 0.01 ppm (0.075 mg/m3), JAN1999                                                                   
                  Occupational Exposure Limit-PERU                                                                       time-weighted average 0,15 mg/m3, JUL2005                                                                               
                  Occupational Exposure Limit-RUSSIA                                                                     time-weighted average 0.05 mg(Pb)/m3, JUN2003                                                                           
                  Occupational Exposure Limit-SWEDEN                                                                     time-weighted average 0.05 mg(Pb)/m3;short term exposure limit 0.2 mg(Pb)/m3, Skin, JUN2005                             
                  Occupational Exposure Limit-SWITZERLAND                                                                MAK-week 0.05 mg(Pb)/m3, KZG-week 0.1 mg(Pb)/m3, skin, JAN2011                                                          
                  Occupational Exposure Limit-THAILAND                                                                   time-weighted average 0.07 mg/m3, JAN1993                                                                               
                  Occupational Exposure Limit-THAILAND                                                                   time-weighted average 0.2 mg(Pb)/m3, JAN1993                                                                            
                  Occupational Exposure Limit-THE NETHERLANDS                                                            MAC-TGG 0.05 mg/m3, Skin, 2003                                                                                          
                  Occupational Exposure Limit-THE PHILIPPINES                                                            time-weighted average 0.07 mg/m3, Skin, JAN1993                                                                         
                  Occupational Exposure Limit-THE PHILIPPINES                                                            time-weighted average 0.15 mg(Pb)/m3, JAN1993                                                                           
                  Occupational Exposure Limit-TURKEY                                                                     time-weighted average 0.2 mg(Pb)/m3, JAN1993                                                                            
                  Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)         8H time-weighted average 0.15 mg(Pb)/m3 (skin)                                                  CFRGBR 29,1926.55,1994  
                  Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)  8H time-weighted average 0.075 mg(Pb)/m3                                                        CFRGBR 41,50-204.50,1994
                  Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)     8H time-weighted average 0.075 mg(Pb)/m3 (skin)                                                 CFRGBR 29,1910.1000,1994
                  Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)            8H time-weighted average 0.15 mg(Pb)/m3 (skin)                                                  CFRGBR 29,1915.1000,1993
                  NIOSH Documentation and Surveillance
                    Organization                                                                                                     Standard                                                                                                                               Reference               
                    National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAMETHYLLEAD-air  10H time-weighted average 0.075 mg/m3 (Sk)                                                                                             NIOSH* DHHS #92-100,1992
                    National Occupational Exposure Survey 1983                                                                       Hazard Code 71860; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 7                          
                    Status in Federal Agencies
                      Organization                                                                       Reference
                      EPA TSCA Section 8(b) CHEMICAL INVENTORY                                                    
                      EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001                                   
                      NIOSH Analytical Method, 1994: Tetramethyl lead (as Pb), 2534                               
                      NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen           
                    Page last reviewed: November 16, 2018
                      Content source: National Institute for Occupational Safety and Health
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