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Original site: www.cdc.gov/niosh-rtecs/TE1D5F88.html | RestoredCDC.org is an independent project, not affiliated with CDC or any federal entity. Visit CDC.gov for free official information. Due to archival on January 6, 2025, recent outbreak data is unavailable. Videos are not restored. Access data.restoredcdc.org for restored data. Use of this site implies acceptance of this disclaimer.[More]About Us Report Bug Compare ContentSkip directly to page optionsThe National Institute for Occupational Safety and Health (NIOSH)Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting PeopleSearchSearch Menu Navigation Menu× NIOSHNIOSH All CDCSubmit* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS Database* The National Institute for Occupational Safety and Health (NIOSH) HomeThe National Institute for Occupational Safety and Health (NIOSH)1. Registry of Toxic Effects of Chemical Substances (RTECS)Phosphorodithioic acid, O,O-dimethyl ester, S-ester with 3-(mercaptomethyl)-1,2,3-benzotriazin-4(3H)-oneRelated PagesRTECS #TE1925000CAS #86-50-0; 54182-73-9See: NMAM or OSHA MethodsUpdatedMarch 2019Molecular Weight317.34Molecular FormulaC10H12N3O3PS2Synonyms1,2,3-Benzotriazin-4(3H)-one, 3-(mercaptomethyl)-, O,O-dimethyl phosphorodithioate3-(Mercaptomethyl)-1,2,3-benzotriazin-4(3H)-one O,O-dimethyl phosphorodithioate S-esterAzinfos-methyl (Dutch)Azinphos methylAzinphosmethylAzinphos-methylAzinphos-methyl (ACGIH:OSHA)Azinphos-metile (Italian)BAY 17147BAY 9027Bayer 17147Bayer 9027Benzotriazine derivative of a methyl dithiophosphateBenzotriazinedithiophosphoric acid dimethoxy esterCarfeneCotneonCotnion methylCrysthion 2LCrysthyonDimethyldithiophosphoric acid N-methylbenzazimide esterENT 23,233GusathionGusathion 25Gusathion MGusathion methylGusathion-20Guthion (DOT:OSHA)Methyl guthionMethylazinphosMethylgusathionMetiltriazotionNCI-C00066N-Methylbenzazimide, dimethyldithiophosphoric acid esterO,O-Dimethyl S-(3,4-dihydro-4-keto-1,2,3-benzotriazinyl-3-methyl) dithiophosphateO,O-Dimethyl S-(4-oxo-1,2,3-benzotriazino(3)-methyl) thiothionophosphateO,O-Dimethyl S-(4-oxo-3H-1,2,3-benzotriazine-3-methyl)phosphorodithioateO,O-Dimethyl S-(4-oxobenzotriazino-3-methyl)phosphorodithioateO,O-Dimethyl S-4-oxo-1,2,3-benzotriazin-3(4H)-ylmethyl phosphorodithioateO,O-Dimethyl-S-((4-oxo-3H-1,2,3-benzotriazin-3-yl)-methyl)-dithiofosfaat (Dutch)O,O-Dimethyl-S-((4-oxo-3H-1,2,3-benzotriazin-3-yl)-methyl)-dithiophosphat (German)O,O-Dimethyl-S-(1,2,3-benzotriazinyl-4-keto)methyl phosphorodithioateO,O-Dimethyl-S-(4-oxobenzotriazin-3-methyl)-dithiophosphat (German)O,O-Dimethyl-S-(benzaziminomethyl) dithiophosphateO,O-Dimetil-S-((4-oxo-3H-1,2,3-benzotriazin-3-il)-metil)-ditiofosfato (Italian)R 1582S-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-ylmethyl) O,O-dimethyl phosphorodithioateS-(3,4-Dihydro-4-oxo-benzo(alpha)(1,2,3)triazin-3-ylmethyl) O,O-dimethyl phosphorodithioateMutation Data and ReferenceSystem Test Route/Organism/Tissue Dose ReferenceCytogenetic Analysis lung/human 120 mg/L CNJGA8 18,665,1976Cytogenetic Analysis other cell types/human 140 mg/L CNJGA8 18,665,1976Cytogenetic Analysis ovary/hamster 60 mg/L/18H-continuous CHROAU 49,77,1974gene conversion and mitotic recombination /Saccharomyes cerevisiae 25 gm/L MUREAV 321,203,1994micronucleus test lymphocyte/human 60 µg/L MUREAV 388,27,1997mutation in mammalian somatic cells lymphocyte/mouse 10 mg/L NTIS** PB84-138973mutation in microorganisms /Schizosaccharomyces pombe 25 mmol/L (+/-enzymatic activation step) MUREAV 117,139,1983mutation in microorganisms /Salmonella typhimurium 7500 µg/plate (-enzymatic activation step) ENMUDM 9(Suppl 9),1,1987mutation in microorganisms /Saccharomyes cerevisiae 10 gm/L (-enzymatic activation step) MUREAV 321,203,1994other mutation test systems ovary/hamster 80 mg/L CHROAU 49,77,1974other mutation test systems fibroblast/human 120 mg/L CNJGA8 18,665,1976Unscheduled DNA Synthesis fibroblast/human 10 µmol/L NTIS** PB268-647Reproductive Effects Data and ReferencesRoute/Organism Dose Effect ReferenceReproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)oral/rat 190 mg/kg (6-22D preg/21D after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) ARTODN 43,177,1980Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)oral/rat 12500 µg/kg (6-15D pregnant) Reproductive: Specific developmental abnormalities: Central nervous system ARTODN 43,177,1980oral/rat 85 mg/kg (6-22D pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** PB288-457oral/rat 20 mg/kg (6-15D pregnant) Reproductive: Other effects on female TIHEEC 14,869,1998oral/mouse 16 mg/kg (8D pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TCMUD8 5,3,1985oral/mouse 20 mg/kg (8D pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TCMUD8 5,3,1985Tumorigenic Data and ReferencesRoute/Organism Dose Effect ReferenceTumorigenic: Equivocal tumorigenic agent by RTECS criteriaoral/rat lowest published toxic dose: 5110 mg/kg/78W- continuous Gastrointestinal: Tumors NCITR* NCI-TR-69,1978Endocrine: Thyroid tumorsTumorigenic: Equivocal tumorigenic agent by RTECS criteriaoral/rat toxic dose: 121 gm/kg/78W- continuous JEPTDQ 1(6),829,1978Gastrointestinal: TumorsAcute Toxicity Data and ReferencesRoute/Organism Dose Effect ReferenceIn Vitro/Human, embryonic cells Inhibitor Concentration (50 percent kill): 1.7 µmol/L/4H Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TIVIEQ 32,190,2016In Vitro/Human, embryonic cells Inhibitor Concentration (50 percent kill): 16.3 µmol/L/24H Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TIVIEQ 32,190,2016In Vitro/Human, embryonic cells Inhibitor Concentration (50 percent kill): 52.2 µmol/L/4H Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases TIVIEQ 32,190,2016In Vitro/Human, embryonic cells Inhibitor Concentration (50 percent kill): 14.3 µmol/L/24H Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases TIVIEQ 32,190,2016In Vitro/Human, embryonic cells Inhibitor Concentration Low: 0.1 µmol/L/4H Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TIVIEQ 32,190,2016In Vitro/Human, embryonic cells Inhibitor Concentration Low: 1 µmol/L/4H Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases TIVIEQ 32,190,2016In Vitro/Human, embryonic cells Inhibitor Concentration Low: 0.1 µmol/L/24H Biochemical: Effect on specific coenzyme: Proportion of isoenzymes TIVIEQ 32,190,2016inhalation/rat lethal concentration (50 percent kill): 69 mg/m3/1H NTIS** PB277-077Eye: Lacrimationintraperitoneal/guinea pig lethal dose (50 percent kill): 40 mg/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 119,208,1957Gastrointestinal: Changes in structure or function of salivary glandsintraperitoneal/mouse lethal dose (50 percent kill): 4 mg/kg PSEBAA 129,699,1968intraperitoneal/rat lethal dose (50 percent kill): 4900 µg/kg PSEBAA 114,509,1963intravenous/rat lethal dose (50 percent kill): 7500 µg/kg NTIS** PB277-077Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)oral/chicken lethal dose (50 percent kill): 277 mg/kg Behavioral: Somnolence (general depressed activity) TXAPA9 11,49,1967Behavioral: Convulsions or effect on seizure thresholdoral/Dog lethal dose (50 percent kill): 10 mg/kg PEMNDP 9,46,1991oral/duck lethal dose (50 percent kill): 136 mg/kg DOEAAH 35,25,1979oral/guinea pig lethal dose (50 percent kill): 80 mg/kg PCOC** -,570,1966oral/mouse lethal dose (50 percent kill): 8600 µg/kg PESTD5 17,292,1976oral/rat lethal dose (50 percent kill): 4 mg/kg ENTOX* -,200,2005oral/rat lethal dose (50 percent kill): 7 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JPPMAB 13,435,1961oral/wild bird lethal dose (50 percent kill): 8500 µg/kg TXAPA9 21,315,1972Behavioral: Somnolence (general depressed activity)skin/guinea pig lethal dose (50 percent kill): >280 mg/kg Behavioral: Muscle weakness KUMJAX 12,313,1959Lung, Thorax, or Respiration: DyspneaBehavioral: Somnolence (general depressed activity)skin/mouse lethal dose (50 percent kill): 65 mg/kg Behavioral: Muscle weakness KUMJAX 12,313,1959Lung, Thorax, or Respiration: Dyspneaskin/rat lethal dose (50 percent kill): 88 mg/kg ENTOX* -,200,2005Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTank with water/other fish toxic concentration: 0.5 µg/l/96H Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases AQUTO* 177,365,2016Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesTank with water/other fish toxic concentration: 10 µg/l/96H Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase AQUTO* 177,365,2016unreported route/quail lethal dose (50 percent kill): 32200 µg/kg FMCHA2 -,C32,1991Brain and Coverings: Other degenerative changesunreported route/rat lowest published toxic dose: 1.5 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 72,309,2003Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseunreported route/rat lethal dose (50 percent kill): 15 mg/kg 30ZDA9 -,371,1971Other Multiple Dose Data and ReferencesRoute/Organism Dose Effect ReferenceBlood: Other changesinhalation/rat lowest published toxic concentration: 4720 µg/m3/6H/12W- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain ARTODN 35,83,1976Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseAutonomic Nervous System: Other (direct) parasympathomimeticintraperitoneal/rat lowest published toxic dose: 120 mg/kg/60D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JPETAB 119,208,1957Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldBehavioral: Somnolence (general depressed activity)oral/Dog lowest published toxic dose: 3094 mg/kg/2Y- continuous Behavioral: Muscle weakness TXAPA9 24,405,1973Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNutritional and Gross Metabolic: Weight loss or decreased weight gainoral/mouse lowest published toxic dose: 174 mg/kg/9D- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase BECTA6 60,194,1998Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldBehavioral: Convulsions or effect on seizure thresholdoral/rat lowest published toxic dose: 3650 mg/kg/2Y- continuous TXAPA9 24,405,1973Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseBrain and Coverings: Other degenerative changesoral/rat lowest published toxic dose: 82810 µg/kg/13W- continuous Blood: Other changes FAATDF 35,101,1997Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseoral/rat lowest published toxic dose: 2184 mg/kg/80W- continuous Endocrine: Thyroid tumors HBPTO* 1,814,2001ReviewsOrganization Standard ReferenceAmerican Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-time-weighted average 0.2 mg/m3 (inhal, vapor, skin, sen) DTLVS* TLV/BEI,2013American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-Not classifiable as a human carcinogen DTLVS* TLV/BEI,2013TOXICOLOGY REVIEW RREVAH 51,123,1974TOXICOLOGY REVIEW AQMOAC #73-19,1973TOXICOLOGY REVIEW RREVAH 46,1,1973TOXICOLOGY REVIEW CNDQA8 10(3),43,1975TOXICOLOGY REVIEW RREVAH 63,1,1976TOXICOLOGY REVIEW MUTAEX 21,93,2006TOXICOLOGY REVIEW ENTOX* -,200,2005TOXICOLOGY REVIEW ENTOX* -,588,2005TOXICOLOGY REVIEW ENTOX* -,308,2005TOXICOLOGY REVIEW MUREAV 584,1,2005TOXICOLOGY REVIEW MUREAV 543,251,2003TOXICOLOGY REVIEW FEREAC 73,80317,2008TOXICOLOGY REVIEW HETOEA 26,321,2007TOXICOLOGY REVIEW FCTOD7 47,2906,2009TOXICOLOGY REVIEW FEREAC 74,46689,2009TOXICOLOGY REVIEW MUREAV 760,1,2014TOXICOLOGY REVIEW NRTXDN 39,158,2013TOXICOLOGY REVIEW TXCYAC 307,46,2013TOXICOLOGY REVIEW TXCYAC 307,136,2013TOXICOLOGY REVIEW TXAPA9 268,157,2013TOXICOLOGY REVIEW FCTOD7 83,300,2015TOXICOLOGY REVIEW MUREAV 802,1,2016Standards and RegulationsOrganization Standard ReferenceEnvironmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES Supported RBREV* -,87,1998Mine Safety and Health Administration (MSHA) STANDARD-air time-weighted average 0.2 mg/m3 (skin) DTLVS* 3,20,1971Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLVOccupational Exposure Limit-AUSTRALIA time-weighted average 0.2 mg/m3, JUL2008Occupational Exposure Limit-AUSTRIA MAK-TMW 0.2 mg/m3;KZW 2 mg/m3, inhal, skin, 2007Occupational Exposure Limit-BELGIUM time-weighted average 0.2 mg/m3, Skin, MAR2002Occupational Exposure Limit-DENMARK time-weighted average 0.2 mg/m3, skin, MAY2011Occupational Exposure Limit-FINLAND time-weighted average 0.02 mg/m3, short term exposure limit 0.06 mg/m3, skin, NOV2011Occupational Exposure Limit-FRANCE VME 0.2 mg/m3, Skin, FEB2006Occupational Exposure Limit-GERMANY MAK 0.2 mg/m3, inhal, 2011Occupational Exposure Limit-ICELAND time-weighted average 0.2 mg/m3, skin, NOV2011Occupational Exposure Limit-KOREA time-weighted average 0.2 mg/m3, skin, 2006Occupational Exposure Limit-MEXICO time-weighted average 0.2 mg/m3;short term exposure limit 0.6 mg/m3 (skin), 2004Occupational Exposure Limit-NEW ZEALAND time-weighted average 0.2 mg/m3, skin, JAN2002Occupational Exposure Limit-NORWAY time-weighted average 0.2 mg/m3, JAN1999Occupational Exposure Limit-PERU time-weighted average 0,2 mg/m3, JUL2005Occupational Exposure Limit-THAILAND time-weighted average 0.2 mg/m3, JAN1993Occupational Exposure Limit-THE NETHERLANDS MAC-TGG 0.2 mg/m3, Skin, 2003Occupational Exposure Limit-THE PHILIPPINES time-weighted average 0.2 mg/m3, Skin, JAN1993Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8H time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1926.55,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8H time-weighted average 0.2 mg/m3 (skin) CFRGBR 41,50-204.50,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8H time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1910.1000,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8H time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1915.1000,1993NIOSH Documentation and SurveillanceOrganization Standard ReferenceNational Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO AZINPHOS-METHYL-air 10H time-weighted average 0.2 mg/m3 (Sk) NIOSH* DHHS #92-100,1992National Occupational Hazard Survey 1974 Hazard Code 35750; Number of Industries 3; Total Number of Facilities 298; Number of Occupations 4; Total Number of Employees Exposed 595Status in Federal AgenciesOrganization ReferenceEPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethalEPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames testEPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversionEPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosisEPA TSCA Section 8(d) unpublished health/safety studiesEPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat NCITR* NCI-TR-69,1978NCI Carcinogenesis Bioassay (feed);no evidence:mouse NCITR* NCI-TR-69,1978NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600Page last reviewed: November 16, 2018Content source: National Institute for Occupational Safety and Health* SyndicateRegistry of Toxic Effects of Chemical Substances (RTECS)* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS DatabaseFollow NIOSH* YouTubeNIOSH Homepage* Workplace Safety & Health Topics* Publications and Products* Programs* Contact NIOSH* About CDC* Contact Us* 800-232-4636Facebook Twitter Instagram LinkedIn Youtube Pinterest SnapchatFacebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat RSS* CONTACT CDCContact UsCall 800-232-4636Email Us* ABOUT CDC+ About CDC+ Jobs+ Funding* POLICIES+ Accessibility+ External Links+ Privacy+ Policies+ Web Policies+ No Fear Act+ FOIA+ OIG+ No Fear Act+ Nondiscrimination+ Vulnerability Disclosure Policy+ CDC Archive+ Public Health Publications+ HHS.gov+ USA.gov* CONNECT WITH US+ Youtube+ Snapchat* LANGUAGES+ Español+ 繁體中文+ Tiếng Việt+ 한국어+ Tagalog+ Русский+ العربية+ Kreyòl Ayisyen+ Français+ Polski+ Português+ Italiano+ Deutsch+ 日本語+ فارسی+ English* U.S. Department of Health & Human Services* Accessibility* External Links* Privacy* Policies* Web Policies* FOIA* OIG* No Fear Act* FOIA* Nondiscrimination* OIG* Vulnerability Disclosure Policy* CDC Archive* Public Health 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