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Original site: www.cdc.gov/niosh-rtecs/RN83D600.html | RestoredCDC.org is an independent project, not affiliated with CDC or any federal entity. Visit CDC.gov for free official information. Due to archival on January 6, 2025, recent outbreak data is unavailable. Videos are not restored. Access data.restoredcdc.org for restored data. Use of this site implies acceptance of this disclaimer.[More]About Us Report Bug Compare ContentSkip directly to page optionsThe National Institute for Occupational Safety and Health (NIOSH)Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting PeopleSearchSearch Menu Navigation Menu× NIOSHNIOSH All CDCSubmit* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS Database* The National Institute for Occupational Safety and Health (NIOSH) HomeThe National Institute for Occupational Safety and Health (NIOSH)1. Registry of Toxic Effects of Chemical Substances (RTECS)7-Oxabicyclo(4.1.0)heptane, 3-(epoxyethyl)-Related PagesRTECS #RN8640000CAS #106-87-6; 25550-49-6See: NMAM or OSHA MethodsUpdatedDecember 2018Molecular Weight140.20Molecular FormulaC8H12O2Synonyms1,2-Epoxy-4-(epoxyethyl)cyclohexane1-Epoxyethyl-3,4-epoxycyclohexane1-Ethyleneoxy-3,4-epoxycyclohexane1-Vinyl-3-cyclohexene dioxide3-(1,2-Epoxyethyl)-7-oxabicyclo(4.1.0)heptane3-Oxiranyl-7-oxabicyclo(4.1.0)heptane4-(1,2-Epoxyethyl)-7-oxabicyclo(4.1.0)heptane4-Vinlycyclohexene dioxide4-Vinyl-1,2-cyclohexene diepoxide4-Vinyl-1-cyclohexene diepoxide4-Vinyl-1-cyclohexene dioxide4-Vinylcyclohexene4-Vinylcyclohexene diepoxideNCI-C60139UCET textile finish 11-74 (Obs.)Vinyl cyclohexene diepoxideVinyl cyclohexene dioxideVinylcyclohexene diepoxideSkin and Eye Irritation and ReferencesRoute/Organism Dose Effect Referenceskin /rabbit 500 mg severe SCCUR* -,9,1961Mutation Data and ReferenceSystem Test Route/Organism/Tissue Dose ReferenceCytogenetic Analysis intraperitoneal/rat 125 mg/kg BJPCAL 6,235,1951Cytogenetic Analysis ovary/hamster 37800 picograms/kg NTPTR* NTP-TR-362,1989DNA Damage intraperitoneal/rat 960 mg/kg TXAPA9 139,394,1996DNA Damage ovary/mouse 10 µmol/L TOXID9 -,283,2008DNA Damage other cell types/human 3.1 gm/L/3H TXAPA9 261,154,2012gene conversion and mitotic recombination /Saccharomyes cerevisiae 25 mmol/L BSIBAC 56,1803,1980mutation in mammalian somatic cells lymphocyte/mouse 25 ng/kg NTPTR* NTP-TR-362,1989mutation in microorganisms /Salmonella typhimurium 50 µg/plate (+/-enzymatic activation step) MUREAV 66,367,1979mutation in microorganisms /Klebsiella pneumoniae 1 mmol/L (-enzymatic activation step) MUREAV 89,269,1981mutation in microorganisms /Saccharomyes cerevisiae 25 mmol/L (-enzymatic activation step) BSIBAC 56,1803,1980sister chromatid exchange ovary/hamster 3730 picograms/kg NTPTR* NTP-TR-362,1989Reproductive Effects Data and ReferencesRoute/Organism Dose Effect ReferenceReproductive: Paternal effects: Testes, epididymis, sperm ductintraperitoneal/mouse 4800 mg/kg (30D male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands TOXID9 12,435,1992Reproductive: Other effects on maleReproductive: Maternal effects: Ovaries, fallopian tubesintraperitoneal/rat 1760 mg/kg (14D prior to copulation/0-7D pregnant) JTSCDR 34,SP59,2009Reproductive: Maternal effects: Ovaries, fallopian tubesReproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)oral/mouse 13468 mg/kg (6-18D pregnant) TOXID9 14,164,1994Reproductive: Specific developmental abnormalities: Urogenital systemTumorigenic Data and ReferencesRoute/Organism Dose Effect ReferenceTumorigenic: Equivocal tumorigenic agent by RTECS criteriaintraperitoneal/rat lowest published toxic dose: 5000 mg/kg/10W- intermittent Lung, Thorax, or Respiration: Tumors BJPCAL 6,235,1951Tumorigenic: Tumors at site of applicationTumorigenic: Carcinogenic by RTECS criteriaskin/mouse lowest published toxic dose: 56 gm/kg/47W- intermittent Skin and Appendages: Tumors JNCIAM 31,41,1963Tumorigenic: Tumors at site of applicationTumorigenic: Carcinogenic by RTECS criteriaskin/mouse lowest published toxic dose: 51500 mg/kg/103W- intermittent NTIS** PB90-219957/ASSkin and Appendages: TumorsTumorigenic: Carcinogenic by RTECS criteriaskin/mouse lowest published toxic dose: 103000 mg/kg/103W- intermittent NTIS** PB90-219957/ASReproductive: Tumorigenic effects: Ovarian tumorsTumorigenic: Equivocal tumorigenic agent by RTECS criteriaskin/mouse toxic dose: 90 gm/kg/74W- intermittent Skin and Appendages: Tumors AIHAAP 24,305,1963Tumorigenic: Tumors at site of applicationTumorigenic: Equivocal tumorigenic agent by RTECS criteriaskin/mouse toxic dose: 12 gm/kg/9W- intermittent Lung, Thorax, or Respiration: Tumors BJPCAL 6,235,1951Skin and Appendages: TumorsTumorigenic: Carcinogenic by RTECS criteriaskin/mouse toxic dose: 10300 mg/kg/2Y- continuous Skin and Appendages: Tumors NTPTR* NTP-TR-362,1989Reproductive: Tumorigenic effects: Ovarian tumorsTumorigenic: Carcinogenic by RTECS criteriaskin/mouse lowest published toxic dose: 60000 mg/kg/60W- intermittent NTIS** PB90-219957/ASSkin and Appendages: TumorsTumorigenic: Carcinogenic by RTECS criteriaskin/mouse lowest published toxic dose: 60000 mg/kg/60W- intermittent Skin and Appendages: Tumors NTIS** PB90-219957/ASReproductive: Maternal effects: Ovaries, fallopian tubesTumorigenic: Carcinogenic by RTECS criteriaskin/rat lowest published toxic dose: 31500 mg/kg/105W- intermittent NTIS** PB90-219957/ASSkin and Appendages: TumorsTumorigenic: Carcinogenic by RTECS criteriaskin/rat lowest published toxic dose: 39375 mg/kg/105W- intermittent NTIS** PB90-219957/ASSkin and Appendages: TumorsTumorigenic: Carcinogenic by RTECS criteriaskin/rat lowest published toxic dose: 31500 mg/kg/2Y- continuous NTPTR* NTP-TR-362,1989Skin and Appendages: TumorsTumorigenic: Equivocal tumorigenic agent by RTECS criteriaunreported route/mouse lowest published toxic dose: 2800 mg/kg Blood: Lymphoma including Hodgkin's disease RARSAM 3,193,1963Skin and Appendages: TumorsAcute Toxicity Data and ReferencesRoute/Organism Dose Effect ReferenceIn Vitro/Hamster, ovary Inhibitor Concentration Low: 0.5 mmol/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. JOETD7 194,733,2016In Vitro/Hamster, ovary Inhibitor Concentration (50 percent kill): 1.4 mmol/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. JOETD7 194,733,2016In Vitro/Hamster, ovary Inhibitor Concentration Low: 1.5 mmol/L/24H In Vitro Toxicity Studies: Apoptosis in vitro JOETD7 194,733,2016In Vitro/jtd Inhibitor Concentration (50 percent kill): 0.8 mmol/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. JOETD7 194,733,2016In Vitro/jtd Inhibitor Concentration Low: 0.5 mmol/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. JOETD7 194,733,2016In Vitro/ptd Inhibitor Concentration Low: 30 µmol/L/4D Endocrine: Other changes TXAPA9 249,1,2010In Vitro/ptd Inhibitor Concentration Low: 30 µmol/L/8D In Vitro Toxicity Studies: Other assays TXAPA9 249,1,2010In Vitro/ptd Inhibitor Concentration Low: 30 µmol/L/8D Reproductive: Maternal effects: Oogenesis TXAPA9 258,118,2012In Vitro/ptd Inhibitor Concentration Low: 30 µmol/L/4D In Vitro Toxicity Studies: Other assays TXAPA9 258,118,2012inhalation/rat lethal concentration (50 percent kill): 800 ppm/4H SCCUR* -,9,1961Reproductive: Maternal effects: Ovaries, fallopian tubesintraperitoneal/mouse lowest published toxic dose: 80 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases TOXID9 1,93,2001Biochemical: Metabolism (intermediary): Otherintraperitoneal/rat lowest published toxic dose: 80 mg/kg Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 66,373,2002Reproductive: Maternal effects: Ovaries, fallopian tubesintraperitoneal/rat lowest published toxic dose: 80 mg/kg BIREBV 67,718,2002Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesintraperitoneal/rat lowest published toxic dose: 320 mg/kg Reproductive: Maternal effects: Oogenesis REPTED 19,71,2004oral/rat lethal dose (50 percent kill): 2130 mg/kg SCCUR* -,9,1961Behavioral: Somnolence (general depressed activity)skin/mouse lowest published lethal dose: 3216 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation NTPTR* NTP-TR-362,1989Skin: After systemic exposure: Dermatitis, otherskin/rabbit lethal dose (50 percent kill): 620 µL/kg UCDS** 9/19/1972unreported route/mouse lowest published toxic dose: 79.914 mg/kg Reproductive: Maternal effects: Ovaries, fallopian tubes TXAPA9 230,109,2008Lung, Thorax, or Respiration: Chronic pulmonary edema or congestionunreported route/rabbit lethal dose (50 percent kill): 680 µg/kg BSIBAC 56,1803,1980Lung, Thorax, or Respiration: Other changesOther Multiple Dose Data and ReferencesRoute/Organism Dose Effect ReferenceBlood: Changes in bone marrow not included in aboveintramuscular/rat lowest published toxic dose: 400 mg/kg/10D- intermittent Blood: Changes in leukocyte (WBC) count AEHLAU 2,50,1961Nutritional and Gross Metabolic: Weight loss or decreased weight gainReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)intraperitoneal/mouse lowest published toxic dose: 4000 mg/kg/5D- intermittent REPTED 9,359,1995Related to Chronic Data: Changes in testicular weightintraperitoneal/mouse lowest published toxic dose: 300 mg/kg/30D- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes REPTED 5,379,1991intraperitoneal/mouse lowest published toxic dose: 1199 mg/kg/15D- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes TXAPA9 221,215,2007Reproductive: Maternal effects: Oogenesisintraperitoneal/mouse lowest published toxic dose: 1200 mg/kg/5D- intermittent REPTED 26,116,2008Related to Chronic Data: Changes in ovarian weightEndocrine: Change in LHintraperitoneal/mouse lowest published toxic dose: 1600 mg/kg/10D- intermittent Endocrine: Change in gonadotropins RTOPDW 81,223,2016Reproductive: Maternal effects: Ovaries, fallopian tubesReproductive: Maternal effects: Uterus, cervix, vaginaintraperitoneal/mouse lowest published toxic dose: 1600 mg/kg/10D- intermittent RTOPDW 81,223,2016Reproductive: Maternal effects: Menstrual cycle changes or disordersintraperitoneal/rat lowest published toxic dose: 1120 mg/kg/2W- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes JTSCDR 34,SP53,2009intraperitoneal/rat lowest published toxic dose: 560 mg/kg/4W- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes JTSCDR 34,SP53,2009Reproductive: Maternal effects: Ovaries, fallopian tubesintraperitoneal/rat lowest published toxic dose: 1760 mg/kg/22D- intermittent JTSCDR 34,SP59,2009Nutritional and Gross Metabolic: Weight loss or decreased weight gainReproductive: Maternal effects: Ovaries, fallopian tubesintraperitoneal/rat lowest published toxic dose: 1200 mg/kg/15D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Proteases TXAPA9 203,114,2005Biochemical: Metabolism (intermediary): Other proteinsintraperitoneal/rat lowest published toxic dose: 1200 mg/kg/15D- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 60,248,2001Reproductive: Maternal effects: Ovaries, fallopian tubesintraperitoneal/rat lowest published toxic dose: 1200 mg/kg/15D- intermittent TOXID9 60,251,2001Biochemical: Metabolism (intermediary): Other proteinsEndocrine: Change in gonadotropinsintraperitoneal/rat lowest published toxic dose: 2400 mg/kg/30D- intermittent Reproductive: Maternal effects: Oogenesis REPTED 16,775,2002Reproductive: Maternal effects: Menstrual cycle changes or disordersReproductive: Maternal effects: Ovaries, fallopian tubesintraperitoneal/rat lowest published toxic dose: 800 mg/kg/10D- intermittent BIREBV 67,718,2002Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesGastrointestinal: Other changesoral/mouse lowest published toxic dose: 65 gm/kg/13W- intermittent Liver: Changes in liver weight FAATDF 14,745,1990Kidney, Ureter, and Bladder: Changes in bladder weightoral/rat lowest published toxic dose: 560 mg/kg/2W- continuous Reproductive: Maternal effects: Oogenesis REPTED 17,273,2003Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)oral/rat lowest published toxic dose: 2800 mg/kg/28D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases ETOPFR 45,28,2016Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)oral/rat lowest published toxic dose: 2800 mg/kg/28D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases ETOPFR 45,28,2016Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesGastrointestinal: Other changesoral/rat lowest published toxic dose: 32500 mg/kg/13W- intermittent Liver: Changes in liver weight FAATDF 14,745,1990Kidney, Ureter, and Bladder: Changes in bladder weightLiver: Changes in liver weightskin/mouse lowest published toxic dose: 6832 mg/kg/14D- intermittent Endocrine: Changes in thymus weight NTPTR* NTP-TR-362,1989Skin: After systemic exposure: Dermatitis, otherLiver: Changes in liver weightskin/mouse lowest published toxic dose: 26 gm/kg/13W- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight NTPTR* NTP-TR-362,1989Skin: After systemic exposure: Dermatitis, otherBrain and Coverings: Changes in brain weightskin/rat lowest published toxic dose: 6552 mg/kg/14D- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight NTPTR* NPT-TR-362,1989Endocrine: Changes in thymus weightSkin: After systemic exposure: Dermatitis, otherskin/rat lowest published toxic dose: 19500 mg/kg/13W- intermittent FAATDF 14,745,1990Skin and Appendages: Other glandsEndocrine: Other changesunreported route/mouse lowest published toxic dose: 1200 mg/kg/5D- intermittent TOXID9 90,80,2006Reproductive: Maternal effects: Ovaries, fallopian tubesunreported route/rat lowest published toxic dose: 1200 mg/kg/15D- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 66,373,2002ReviewsOrganization Standard ReferenceAmerican Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-time-weighted average 0.1 ppm (skin) DTLVS* TLV/BEI,2013American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-Confirmed animal carcinogen DTLVS* TLV/BEI,2013International Agency for Research on Cancer (IARC) Cancer Review:Animal Limited Evidence IMEMDT 11,141,1976International Agency for Research on Cancer (IARC) Cancer Review:Animal Sufficient Evidence IMEMDT 60,361,1994International Agency for Research on Cancer (IARC) Cancer Review:Human No Adequate Data IMEMDT 11,141,1976International Agency for Research on Cancer (IARC) Cancer Review:Human Inadequate Evidence IMEMDT 60,361,1994International Agency for Research on Cancer (IARC) Cancer Review:Group 2B IMEMDT 60,361,1994TOXICOLOGY REVIEW JTSCDR 34,SP1,2009TOXICOLOGY REVIEW REPTED 49,117,2014Standards and RegulationsOrganization Standard ReferenceOccupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLVOccupational Exposure Limit-AUSTRALIA time-weighted average 10 ppm (57 mg/m3), Carcinogen, JUL2008Occupational Exposure Limit-BELGIUM time-weighted average 0.1 ppm (0.58 mg/m3), Skin, MAR2002Occupational Exposure Limit-DENMARK time-weighted average 10 ppm (60 mg/m3), carc, MAY2011Occupational Exposure Limit-FINLAND time-weighted average 0.5 ppm (2.9 mg/m3), skin, NOV2011Occupational Exposure Limit-ICELAND time-weighted average 10 ppm (60 mg/m3), NOV2011Occupational Exposure Limit-JAPAN 2B carc, MAY2012Occupational Exposure Limit-KOREA time-weighted average 10 ppm (60 mg/m3), skin, 2006Occupational Exposure Limit-MEXICO time-weighted average 10 ppm (60 mg/m3), 2004Occupational Exposure Limit-NEW ZEALAND time-weighted average 10 ppm (57 mg/m3), skin, JAN2002Occupational Exposure Limit-NORWAY time-weighted average 10ppm (60 mg/m3), JAN1999Occupational Exposure Limit-PERU time-weighted average 0,1 ppm (0,57 mg/m3), JUL2005Occupational Exposure Limit-SWITZERLAND carc 2, JAN2011Occupational Exposure Limit-THE NETHERLANDS MAC-TGG 60 mg/m3, 2003NIOSH Documentation and SurveillanceOrganization Standard ReferenceNational Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL CYCLOHEXENE DIOXIDE-air 10H Carcinogen time-weighted average 10 ppm (Sk) NIOSH* DHHS #92-100,1992National Occupational Exposure Survey 1983 Hazard Code M1392; Number of Industries 14; Total Number of Facilities 107; Number of Occupations 24; Total Number of Employees Exposed 6224; Total Number of Female Employees Exposed 1718National Occupational Hazard Survey 1974 Hazard Code M1392; Number of Industries 7; Total Number of Facilities 181; Number of Occupations 11; Total Number of Employees Exposed 2028Status in Federal AgenciesOrganization ReferenceEPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82EPA TSCA Section 8(b) CHEMICAL INVENTORYEPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001NCI Carcinogenesis Studies (gavage);clear evidence:mouse,ratNTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogenPage last reviewed: November 16, 2018Content source: National Institute for Occupational Safety and Health* SyndicateRegistry of Toxic Effects of Chemical Substances (RTECS)* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS DatabaseFollow NIOSH* YouTubeNIOSH Homepage* Workplace Safety & Health Topics* Publications and Products* Programs* Contact NIOSH* About CDC* Contact Us* 800-232-4636Facebook Twitter Instagram LinkedIn Youtube Pinterest SnapchatFacebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat RSS* CONTACT CDCContact UsCall 800-232-4636Email Us* ABOUT CDC+ About CDC+ Jobs+ Funding* POLICIES+ Accessibility+ External Links+ Privacy+ Policies+ Web Policies+ No Fear Act+ FOIA+ OIG+ No Fear Act+ Nondiscrimination+ Vulnerability Disclosure Policy+ CDC Archive+ Public Health Publications+ HHS.gov+ USA.gov* CONNECT WITH US+ Youtube+ Snapchat* LANGUAGES+ Español+ 繁體中文+ Tiếng Việt+ 한국어+ Tagalog+ Русский+ العربية+ Kreyòl Ayisyen+ Français+ Polski+ Português+ Italiano+ Deutsch+ 日本語+ فارسی+ English* U.S. Department of 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