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Original site: www.cdc.gov/niosh-rtecs/MUAAE60.html | RestoredCDC.org is an independent project, not affiliated with CDC or any federal entity. Visit CDC.gov for free official information. Due to archival on January 6, 2025, recent outbreak data is unavailable. Videos are not restored. Access data.restoredcdc.org for restored data. Use of this site implies acceptance of this disclaimer.[More]About Us Report Bug Compare ContentSkip directly to page optionsThe National Institute for Occupational Safety and Health (NIOSH)Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting PeopleSearchSearch Menu Navigation Menu× NIOSHNIOSH All CDCSubmit* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS Database* The National Institute for Occupational Safety and Health (NIOSH) HomeThe National Institute for Occupational Safety and Health (NIOSH)1. Registry of Toxic Effects of Chemical Substances (RTECS)Hydantoin, 1,3-dichloro-5,5-dimethyl-Related PagesRTECS #MU0700000CAS #118-52-5; 55945-60-3See: NMAM or OSHA MethodsUpdatedSeptember 2013Molecular Weight197.03Molecular FormulaC5H6Cl2N2O2Synonyms1,3-Dichloro-5,5-dimethyl hydantoin1,3-Dichloro-5,5-dimethyl hydantoin (ACGIH:OSHA)1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione1,3-Dichloro-5,5-dimethylhydantoin1,3-Dichloro-5,5'-methylhydantoin1,3-Dwuchloro-5,5-dwumetylohydantoina (Polish)2,4-Imidazolidinedione, 1,3-dichloro-5,5-dimethyl- (9CI)DactinDaktinDantoinDichlorantinDwuchlorantyny (Polish)HalaneHydanHydan (antiseptic)Hydantoin, dichlorodimethyl-NCI-C03054OmchlorSkin and Eye Irritation and ReferencesRoute/Organism Dose Effect Referenceskin /rabbit 500 mg/24H severe EPASR* 8EHQ-0281-0382skin /rabbit 100 mg/24H severe EPASR* 8EHQ-0281-0382Mutation Data and ReferenceSystem Test Route/Organism/Tissue Dose Referencemorphological transform embryo/rat 6300 ng/plate JJATDK 1,190,1981sex chromosome loss and nondisjunction parenteral/Drosophila melanogaster 250 ppm ENMUDM 7,677,1985Acute Toxicity Data and ReferencesRoute/Organism Dose Effect ReferenceBehavioral: Tremorinhalation/rat Lowest published lethal concentration: 20 gm/m3/1H Lung, Thorax, or Respiration: Respiratory stimulation EPASR* 8EHQ-0281-0382Gastrointestinal: Changes in structure or function of salivary glandsBehavioral: Somnolence (general depressed activity)oral/guinea pig lethal dose (50 percent kill): 1350 mg/kg Behavioral: Withdrawal GISAAA 47(6),76,1982Lung, Thorax, or Respiration: DyspneaBehavioral: Somnolence (general depressed activity)oral/rabbit lethal dose (50 percent kill): 1520 mg/kg Behavioral: Withdrawal GISAAA 47(6),76,1982Lung, Thorax, or Respiration: Dyspneaoral/rat lethal dose (50 percent kill): 542 mg/kg 85INA8 5,183,1986skin/rabbit lethal dose (50 percent kill): >20 gm/kg EPASR* 8EHQ-0281-0382unreported route/mammal (species unspecified) lethal dose (50 percent kill): 500 mg/kg GWXXBX #2550828unreported route/rat lethal dose (50 percent kill): 550 mg/kg BCTKAG 19,52,1986Other Multiple Dose Data and ReferencesRoute/Organism Dose Effect Referenceoral/rat lowest published toxic dose: 8784 mg/kg/28D- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BCTKAG 19,52,1986Brain and Coverings: Recordings from specific areas of CNSoral/rat lowest published toxic dose: 634 mg/kg/30D- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 47(6),76,1982Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesReviewsOrganization Standard ReferenceAmerican Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3 DTLVS* TLV/BEI,2013Standards and RegulationsOrganization Standard ReferenceEnvironmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989Mine Safety and Health Administration (MSHA) STANDARD-air time-weighted average 0.2 mg/m3 DTLVS* 3,78,1971Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLVOccupational Exposure Limit-AUSTRALIA time-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, JUL2008Occupational Exposure Limit-AUSTRIA MAK-TMW 0.2 mg/m3;KZW 0.4 mg/m3, inhal, 2007Occupational Exposure Limit-BELGIUM time-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, MAR2002Occupational Exposure Limit-DENMARK time-weighted average 0.2 mg/m3, MAY2011Occupational Exposure Limit-FINLAND time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, NOV2011Occupational Exposure Limit-FRANCE VME 0.2 mg/m3, FEB2006Occupational Exposure Limit-ICELAND time-weighted average 0.2 mg/m3, NOV2011Occupational Exposure Limit-KOREA time-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, 2006Occupational Exposure Limit-MEXICO time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3, 2004Occupational Exposure Limit-NEW ZEALAND time-weighted average 0.2 mg/m3; short term exposure limit 0.4 mg/m3, JAN2002Occupational Exposure Limit-PERU time-weighted average 0.2 mg/m3; short term exposure limit 0.4 mg/m3, JUL2005Occupational Exposure Limit-RUSSIA short term exposure limit 2 mg/m3, JUN2003Occupational Exposure Limit-SWITZERLAND MAK-week 0.2 mg/m3, inhal, JAN2011Occupational Exposure Limit-THE NETHERLANDS MAC-TGG 0.2 mg/m3, 2003Occupational Exposure Limit-THE PHILIPPINES time-weighted average 0.2 mg/m3, JAN1993Occupational Exposure Limit-UNITED KINGDOM time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3, OCT2007Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8H time-weighted average 0.2 mg/m3 CFRGBR 29,1926.55,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8H time-weighted average 0.2 mg/m3 CFRGBR 41,50-204.50,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8H time-weighted average 0.2 mg/m3 CFRGBR 29,1910.1000,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8H time-weighted average 0.2 mg/m3 CFRGBR 29,1915.1000,1993NIOSH Documentation and SurveillanceOrganization Standard ReferenceNational Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10H time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3 NIOSH* DHHS #92-100,1992National Occupational Exposure Survey 1983 Hazard Code 24100; Number of Industries 9; Total Number of Facilities 436; Number of Occupations 10; Total Number of Employees Exposed 3502; Total Number of Female Employees Exposed 1780National Occupational Hazard Survey 1974 Hazard Code 24100; Number of Industries 5; Total Number of Facilities 729; Number of Occupations 6; Total Number of Employees Exposed 2224Status in Federal AgenciesOrganization ReferenceEPA TSCA Section 8(b) CHEMICAL INVENTORYEPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001Page last reviewed: November 16, 2018Content source: National Institute for Occupational Safety and Health* SyndicateRegistry of Toxic Effects of Chemical Substances (RTECS)* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS DatabaseFollow NIOSH* YouTubeNIOSH Homepage* Workplace Safety & Health Topics* Publications and Products* Programs* Contact NIOSH* About CDC* Contact Us* 800-232-4636Facebook Twitter Instagram LinkedIn Youtube Pinterest SnapchatFacebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat RSS* CONTACT CDCContact UsCall 800-232-4636Email Us* ABOUT CDC+ About CDC+ Jobs+ Funding* POLICIES+ Accessibility+ External Links+ Privacy+ Policies+ Web Policies+ No Fear Act+ FOIA+ OIG+ No Fear Act+ Nondiscrimination+ Vulnerability Disclosure Policy+ CDC Archive+ Public Health Publications+ HHS.gov+ USA.gov* CONNECT WITH US+ Youtube+ Snapchat* LANGUAGES+ Español+ 繁體中文+ Tiếng Việt+ 한국어+ Tagalog+ Русский+ العربية+ Kreyòl Ayisyen+ Français+ Polski+ Português+ Italiano+ Deutsch+ 日本語+ فارسی+ English* U.S. Department of Health & Human Services* Accessibility* External Links* Privacy* Policies* Web Policies* FOIA* OIG* No Fear Act* FOIA* Nondiscrimination* OIG* Vulnerability Disclosure Policy* CDC Archive* Public Health Publications* HHS.gov* USA.govContent Credential×This image was edited or created using GenAI (generative artificial intelligence).Our experts review all images in an effort to ensure accuracy and quality before use.Learn more about CDC's usage of GenAI.Exit Notification/Disclaimer PolicyCloseLinks with this icon indicate that you are leaving the CDC website.* The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.* Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.* You will be subject to the destination website's privacy policy when you follow the link.* CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.For more information on CDC's web notification policies, see Website Disclaimers.Cancel Continue
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