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          The National Institute for Occupational Safety and Health (NIOSH)
         1. Registry of Toxic Effects of Chemical Substances (RTECS)
      Hexane, 1,6-diisocyanato-
            Related Pages
                RTECS #
                  MO1740000
                CAS #
                  822-06-0; 66368-96-5
                  See: NMAM or OSHA Methods
                Updated
                  December 2018
                Molecular Weight
                  168.22
                Molecular Formula
                  C8H12N2O2
                Synonyms
                  1,6-Diisocyanatohexane
                  1,6-Hexamethylene diisocyanate
                  1,6-Hexanediol diisocyanate
                  Desmodur H
                  Desmodur N
                  HDI
                  HDI-IC
                  Hexamethylendiisokyanat (Czech)
                  Hexamethylene diisocyanate
                  Hexamethylene diisocyanate (ACGIH)
                  Hexamethylene-1,6-diisocyanate
                  HMDI
                  Isocyanic acid, diester with 1,6-hexanediol
                  Isocyanic acid, hexamethylene ester
                  Metyleno-bis-fenyloizocyjanian (Polish)
                  Szesciometylenodwuizocyjanian (Polish)
                  TL 78
        Acute Toxicity Data and References
          Route/Organism                   Dose                                                    Effect                                                                                                       Reference            
          In Vitro/Human, lung             Inhibitor Concentration (20 percent kill): 1.1 mmol/L   In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.  TIVIEQ 30,274,2015   
          In Vitro/Human, lung fibroblast  Inhibitor Concentration Low: 95 µmol/L/6H               In Vitro Toxicity Studies: Other assays                                                                      TIVIEQ 28,209,2014   
          In Vitro/Human, skin             Inhibitor Concentration (20 percent kill): 40 mg/L/24H  In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.  TIVIEQ 27,1127,2013  
          inhalation/mouse                 lethal concentration (50 percent kill): 30 mg/m3                                                                                                                     85GMAT -,74,1982     
                                                                                                   Eye: Lacrimation                                                                                                                  
          inhalation/rat                   Lowest published lethal concentration: 60 mg/m3/4H      Lung, Thorax, or Respiration: Dyspnea                                                                        GTPZAB 12(10),40,1968
                                                                                                   Nutritional and Gross Metabolic: Weight loss or decreased weight gain                                                             
          inhalation/rat                   lethal concentration (50 percent kill): 124 mg/m3/4H                                                                                                                 TOSCF2 58,173,2000   
                                                                                                   Lung, Thorax, or Respiration: Changes in lung weight                                                                              
          inhalation/rat                   lethal concentration (50 percent kill): 462 mg/m3/4H                                                                                                                 TOSCF2 58,173,2000   
                                                                                                   Biochemical: Metabolism (intermediary): Other proteins                                                                            
                                                                                                   Lung, Thorax, or Respiration: Other changes                                                                                       
          inhalation/rat                   lowest published toxic concentration: 15.9 mg/m3/6H                                                                                                                  TOSCF2 58,173,2000   
                                                                                                   Nutritional and Gross Metabolic: Weight loss or decreased weight gain                                                             
                                                                                                   Lung, Thorax, or Respiration: Consolidation                                                                                       
          inhalation/rat                   lowest published toxic concentration: 54.3 mg/m3/6H     Lung, Thorax, or Respiration: Acute pulmonary edema                                                          TOSCF2 58,173,2000   
                                                                                                   Lung, Thorax, or Respiration: Pleural effusion                                                                                    
          inhalation/rat                   lowest published toxic concentration: 118.1 mg/m3/6H                                                                                                                 TOSCF2 58,173,2000   
          intravenous/mouse                lethal dose (50 percent kill): 5600 µg/kg                                                                                                                            CSLNX* NX#07805      
          oral/mouse                       lethal dose (50 percent kill): 350 mg/kg                                                                                                                             TAKHAA 39,202,1980   
          oral/rat                         lethal dose (50 percent kill): 710 µL/kg                                                                                                                             AIHAAP 30,470,1969   
          skin/rabbit                      lethal dose (50 percent kill): 570 µL/kg                                                                                                                             AIHAAP 30,470,1969   
          Other Multiple Dose Data and References
            Route/Organism         Dose                                                                 Effect                                                                                       Reference          
            inhalation/guinea pig  lowest published toxic concentration: 1 ppm/6H/5D- intermittent      Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field                        NTIS** OTS0571057  
                                                                                                        Nutritional and Gross Metabolic: Weight loss or decreased weight gain                                           
            inhalation/mouse       lowest published toxic concentration: 300 ppb/6H/5D- intermittent                                                                                                 NTIS** OTS0571057  
                                                                                                        Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field                                           
                                                                                                        Immunological Including Allergic: Increased immune response                                                     
            inhalation/mouse       lowest published toxic concentration: 7.5 mg/m3/3D- intermittent     Biochemical: Metabolism (intermediary): Other proteins                                       TXCYAC 261,103,2009
                                                                                                        Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation                     
            inhalation/rat         lowest published toxic concentration: 0.05 ppm/6H/28D- intermittent  Olfaction: Other olfaction effects                                                           REPTED 14,135,2000 
            inhalation/rat         lowest published toxic concentration: 0.05 ppm/6H/47D- intermittent  Olfaction: Other olfaction effects                                                           REPTED 14,135,2000 
            inhalation/rat         lowest published toxic concentration: 0.05 ppm/20D- continuous       Olfaction: Other olfaction effects                                                           TJADAB 162,205,2000
            inhalation/rat         lowest published toxic concentration: 50 ppb/6H/30D- intermittent    Olfaction: Other olfaction effects                                                           REPTED 14,135,2000 
            inhalation/rat         lowest published toxic concentration: 2 ppm/6H/5D- intermittent      Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field                        NTIS** OTS0571057  
                                                                                                        Olfaction: Other olfaction effects                                                                              
            inhalation/rat         lowest published toxic concentration: 40 ppb/6H/13W- intermittent                                                                                                 NTIS** OTS0532755  
                                                                                                        Eye: Conjunctiva irritation                                                                                     
                                                                                                        Behavioral: Convulsions or effect on seizure threshold                                                          
            inhalation/rat         lowest published toxic concentration: 30 ppm/4H/2W- intermittent     Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi          NTIS** OTS0555659  
                                                                                                        Lung, Thorax, or Respiration: Dyspnea                                                                           
                                                                                                        Gastrointestinal: Changes in structure or function of salivary glands                                           
            oral/rat               lowest published toxic dose: 3 gm/kg/2W- intermittent                Gastrointestinal: Hypermotility, diarrhea                                                    NTIS** OTS0555659  
                                                                                                        Nutritional and Gross Metabolic: Weight loss or decreased weight gain                                           
                                                                                                        Immunological Including Allergic: Increased immune response                                                     
            skin/mouse             lowest published toxic dose: 1 pph/3D- intermittent                  Biochemical: Metabolism (intermediary): Other proteins                                       TXCYAC 261,103,2009
                                                                                                        Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation                     
            Reviews
              Organization                                                       Standard                                               Reference              
              American Conference of Governmental Industrial Hygienists (ACGIH)  Threshold Limit Value-time-weighted average 0.005 ppm  DTLVS* TLV/BEI,2013    
              TOXICOLOGY REVIEW                                                                                                         TOLED5 140-141,213,2003
              TOXICOLOGY REVIEW                                                                                                         FCTOD7 55,596,2013     
              TOXICOLOGY REVIEW                                                                                                         RTOPDW 55,43,2009      
              Standards and Regulations
                Organization                                                                           Standard                                                                                                     Reference
                Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;                                                                                                                        
                Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV                                                                                                                                            
                Occupational Exposure Limit-AUSTRALIA                                                  time-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, JUL2008                             
                Occupational Exposure Limit-AUSTRIA                                                    MAK-TMW 0.005 ppm (0.035 mg/m3);KZW 0.005 ppm (0.035 mg/m3), sen, 2007                                                
                Occupational Exposure Limit-BELGIUM                                                    time-weighted average 0.005 ppm (0.034 mg/m3), MAR2002                                                                
                Occupational Exposure Limit-DENMARK                                                    time-weighted average 0.005 ppm (0.035 mg/m3), MAY2011                                                                
                Occupational Exposure Limit-FRANCE                                                     VME 0.01 ppm (0.075 mg/m3), VLE 0.02 ppm (0.15 mg/m3), FEB2006                                                        
                Occupational Exposure Limit-GERMANY                                                    MAK 0.005 ppm (0.035 mg/m3), 2011                                                                                     
                Occupational Exposure Limit-HUNGARY                                                    time-weighted average 0.035 mg/m3, short term exposure limit 0.035 mg/m3, SEP2000                                     
                Occupational Exposure Limit-ICELAND                                                    time-weighted average 0.005 ppm (0.03 mg/m3), short term exposure limit 0.01 ppm (0.07 mg/m3), sen, NOV2011           
                Occupational Exposure Limit-JAPAN                                                      Occupational Exposure Limit 0.005 ppm (0.034 mg/m3), a1 sen, MAY2012                                                  
                Occupational Exposure Limit-NEW ZEALAND                                                time-weighted average 0.02 mg(NCO)/m3; short term exposure limit 0.07 mg(NCO)/m3, sen, JAN2002                        
                Occupational Exposure Limit-PERU                                                       time-weighted average 0,005 ppm (0,034 mg/m3), JUL2005                                                                
                Occupational Exposure Limit-POLAND                                                     MAC(time-weighted average) 0.05 mg/m3, short term exposure limit 0.15 mg/m3, JAN1999                                  
                Occupational Exposure Limit-RUSSIA                                                     short term exposure limit 0.05 mg/m3, Skin, JUN2003                                                                   
                Occupational Exposure Limit-SWEDEN                                                     time-weighted average 0.002 ppm (0.02 mg/m3), ceiling concentration 0.005 ppm (0.03 mg/m3), Sen, JUN2005              
                Occupational Exposure Limit-SWITZERLAND                                                ceiling concentration 0.02 mg(NCO)/m3, skin, sen, JAN2011                                                             
                Occupational Exposure Limit-THE NETHERLANDS                                            MAC-TGG 0.04 mg/m3, 2003                                                                                              
                NIOSH Documentation and Surveillance
                  Organization                                                                                         Standard                                                                                                                                                                                      Reference               
                  National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HDI-air  10H time-weighted average 0.035 mg/m3;ceiling concentration 0.14 mg/m3/10M                                                                                                                    NIOSH* DHHS #92-100,1992
                  National Occupational Exposure Survey 1983                                                           Hazard Code M4839; Number of Industries 21; Total Number of Facilities 1895; Number of Occupations 26; Total Number of Employees Exposed 19180; Total Number of Female Employees Exposed 329                          
                  National Occupational Hazard Survey 1974                                                             Hazard Code M4839; Number of Industries 9; Total Number of Facilities 238; Number of Occupations 12; Total Number of Employees Exposed 4490                                                                           
                  Status in Federal Agencies
                    Organization                                                 Reference
                    ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/102543/AS)                     
                    EPA TSCA Section 8(b) CHEMICAL INVENTORY                              
                    EPA TSCA Section 8(d) unpublished health/safety studies               
                    EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001             
                    NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521           
                    NIOSH Analytical Method, 1996: Isocyanates, 5522                      
                    On EPA IRIS database                                                  
                    OSHA ANALYTICAL METHOD #42                                            
                  Page last reviewed: November 16, 2018
                    Content source: National Institute for Occupational Safety and Health
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