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Original site: www.cdc.gov/niosh-rtecs/KW2D6518.html | RestoredCDC.org is an independent project, not affiliated with CDC or any federal entity. Visit CDC.gov for free official information. Due to archival on January 6, 2025, recent outbreak data is unavailable. Videos are not restored. Access data.restoredcdc.org for restored data. Use of this site implies acceptance of this disclaimer.[More]About Us Report Bug Compare ContentSkip directly to page optionsThe National Institute for Occupational Safety and Health (NIOSH)Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting PeopleSearchSearch Menu Navigation Menu× NIOSHNIOSH All CDCSubmit* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS Database* The National Institute for Occupational Safety and Health (NIOSH) HomeThe National Institute for Occupational Safety and Health (NIOSH)1. Registry of Toxic Effects of Chemical Substances (RTECS)Ethylene glycolRelated PagesRTECS #KW2975000CAS #107-21-1; 71767-64-1See: NMAM or OSHA MethodsUpdatedMarch 2019Molecular Weight62.08Molecular FormulaC2H6O2Synonyms1,2-Dihydroxyethane1,2-Ethandiol1,2-EthanediolAthylenglykol (German)Dowtherm SR 1Ethane-1,2-diolEthylene alcoholEthylene dihydrateEthylene glycol (ACGIH)Ethylene glycol, aerosolGlycol alcoholLutrol-9M.E.G.Macrogol 400 BPCMonoethylene glycolNCI-C00920NorkoolTescolUcar 17Skin and Eye Irritation and ReferencesRoute/Organism Dose Effect Referenceeye /rabbit 500 mg/24H mild 85JCAE -,205,1986eye /rabbit 100 mg/1H mild NTIS** LMF-69eye /rabbit 0.012 ppm/3D TXAPA9 16,646,1970eye /rabbit 1440 mg/6H moderate BUYRAI 31,25,1977eye /rat 0.012%/3D TXAPA9 16,646,1970skin /rabbit 555 mg open irritation test mild UCDS** 7/21/1965Mutation Data and ReferenceSystem Test Route/Organism/Tissue Dose ReferenceCytogenetic Analysis oral/rat 1200 mg/kg TGANAK 19,436,1985DNA Damage ovary/hamster 50 gm/L/2H (+enzymatic activation step) FCTOD7 48,1905,2010DNA inhibition lymphocyte/human 320 mmol/L PNASA6 79,1171,1982micronucleus test ovary/hamster 50 gm/L/3H (+enzymatic activation step) FCTOD7 48,1905,2010mutation in mammalian somatic cells lymphocyte/mouse 100 mmol/L PAACA3 21,74,1980Reproductive Effects Data and ReferencesRoute/Organism Dose Effect ReferenceReproductive: Other effects on femaleinhalation/rat 2500 mg/m3/6H (6-15D pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 24,57,1995Reproductive: Other developmental abnormalitiesReproductive: Maternal effects: Uterus, cervix, vaginainhalation/mouse 1000 mg/m3/6H (6-15D pregnant) Reproductive: Other effects on female FAATDF 24,57,1995Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)inhalation/mouse 1000 mg/m3/6H (6-15D pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 24,57,1995Reproductive: Effects on newborn: Sex ratioReproductive: Other effects on femaleinhalation/mouse 2100 mg/m3/6H (6-15D pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) FAATDF 27,49,1995Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)inhalation/mouse 2100 mg/m3/6H (6-15D pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 27,49,1995Reproductive: Specific developmental abnormalities: Musculoskeletal systemoral/rabbit 28 gm/kg (6-19D pregnant) Reproductive: Other effects on female NTIS** PB91-211219Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)oral/mouse 88720 mg/kg (7-14D pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) EVHPAZ 57,141,1984Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)oral/mouse 7500 mg/kg (6-15D pregnant) TXAPA9 81,113,1985Reproductive: Specific developmental abnormalities: Musculoskeletal systemReproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)oral/mouse 7500 mg/kg (6-15D pregnant) TJADAB 29(2),52A,1984Reproductive: Specific developmental abnormalities: Musculoskeletal systemReproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)oral/mouse 84 gm/kg (1-21D preg/21D after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 4,136,1984Reproductive: Effects on newborn: Delayed effectsReproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)oral/mouse 88720 mg/kg (7-14D pregnant) Reproductive: Effects on newborn: Stillbirth EVHPAZ 57,141,1984Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)Reproductive: Maternal effects: Uterus, cervix, vaginaoral/mouse 15 gm/kg (6-15D pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) NTIS** PB85-105385Reproductive: Effects on fertility: Other measures of fertilityReproductive: Specific developmental abnormalities: Skin and skin appendagesoral/rat 50 gm/kg (6-15D pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 81,113,1985Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)oral/rat 8580 mg/kg (6-15D pregnant) CHYCDW 20,289,1986Reproductive: Specific developmental abnormalities: Musculoskeletal systemReproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)oral/rat 12500 mg/kg (6-15D pregnant) TJADAB 29(2),52A,1984Reproductive: Specific developmental abnormalities: Musculoskeletal systemReproductive: Maternal effects: Uterus, cervix, vaginaoral/rat 25 gm/kg (6-15D pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** PB85-104594Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)oral/rat 51948 mg/kg (13W male) Reproductive: Paternal effects: Testes, epididymis, sperm duct WDZAEK 8,12,1994Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)oral/mouse 413 gm/kg (15W male/15W pre-3W after birth) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TXAPA9 81,100,1985Reproductive: Specific developmental abnormalities: Musculoskeletal systemoral/mouse 413 gm/kg (15W male/15W pre-3W after birth) Reproductive: Effects on newborn: Delayed effects TXAPA9 81,100,1985Reproductive: Specific developmental abnormalities: Musculoskeletal systemoral/mouse 1.7 gm/kg (multigenerations) NTIS** #PB84241108Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)oral/mouse 1.7 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Central nervous system NTIS** #PB84241108oral/mouse 1.7 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system NTIS** #PB84241108oral/mouse 7.5 gm/kg (6-15D pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB85-105385Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)oral/mouse 7.5 gm/kg (6-15D pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** #PB85-105385Reproductive: Other developmental abnormalitiesoral/mouse 29.75 gm/kg (7D male/7D prior to copulation/21D pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB84241108Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)oral/mouse 59.5 gm/kg (7D male/7D prior to copulation/21D pregnant) NTIS** #PB84241108Reproductive: Effects on fertility: Other measures of fertilityoral/mouse 98 gm/kg (7D male/7D prior to copulation/21D pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** #PB86177383oral/mouse 294 gm/kg (15W prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB86177383Reproductive: Effects on fertility: Other measures of fertilityoral/mouse 15 gm/kg (6-15D pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** #PB85-105385Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)oral/mouse 15 gm/kg (6-15D pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** #PB85-105385Reproductive: Maternal effects: Parturitionoral/rat 18.8 gm/kg (6-20D pregnant) NTIS** #PB88-204326/ASReproductive: Specific developmental abnormalities: Urogenital systemoral/mouse 850 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB86177383oral/mouse 850 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system NTIS** #PB86177383Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)oral/rat 25000 mg/kg (6-15D pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** #PB95-274528Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)Reproductive: Effects on fertility: Abortionoral/rabbit 28000 mg/kg (6-19D pregnant) NTIS** #PB91-211219Reproductive: Effects on newborn: StillbirthReproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)oral/rat 33750 mg/kg (6-20D pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) NTIS** #PB88-204326/ASReproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)Reproductive: Specific developmental abnormalities: Central nervous systemoral/rat 33750 mg/kg (6-20D pregnant) NTIS** #PB88-204326/ASReproductive: Specific developmental abnormalities: Musculoskeletal systemReproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)unreported route/rat 50000 mg/kg (6-15D pregnant) Reproductive: Other developmental abnormalities VCVGK* -,140,1994Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)unreported route/mouse 7500 mg/kg (6-15D pregnant) Reproductive: Other developmental abnormalities VCVGK* -,140,1994Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)unreported route/rat 5000 mg/kg (multigenerations) Reproductive: Other developmental abnormalities VCVGK* -,140,1994Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)unreported route/mouse 750 mg/kg (multigenerations) Reproductive: Other developmental abnormalities VCVGK* -,140,1994Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)Acute Toxicity Data and ReferencesRoute/Organism Dose Effect Referenceeye/rabbit lowest published toxic dose: 10 pph Eye: Conjunctiva irritation VCVGK* -,141,1984In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 1706485 µmol/L/21H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 7,653,1993In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 712350 µmol/L/21H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 7,653,1993In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 1447621 µmol/L/20H In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. TIVIEQ 7,653,1993In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 591179 µmol/L/20H In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. TIVIEQ 7,653,1993In Vitro/Hamster, lung fibroblast Inhibitor Concentration (50 percent kill): 365 mmol/L/60H In Vitro Toxicity Studies: Cell counting TIVIEQ 7,511,1993In Vitro/Hamster, lung fibroblast Inhibitor Concentration (10 percent kill): 100 mmol/L/60H In Vitro Toxicity Studies: Cell counting TIVIEQ 7,511,1993In Vitro/Human, HeLa cell Inhibitor Concentration (50 percent kill): 415 mmol/L/60H In Vitro Toxicity Studies: Cell counting TIVIEQ 7,511,1993In Vitro/Human, HeLa cell Inhibitor Concentration (10 percent kill): 117.5 mmol/L/60H In Vitro Toxicity Studies: Cell counting TIVIEQ 7,511,1993In Vitro/Human, kidney Inhibitor Concentration Low: 100 µmol/L/6H In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) TXCYAC 290,82,2011In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)In Vitro/Human, kidney Inhibitor Concentration Low: 100 µmol/L/12H TXCYAC 290,82,2011In Vitro Toxicity Studies: Other assaysIn Vitro/Human, kidney tumor Inhibitor Concentration (50 percent kill): 70800 mg/L In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. TIVIEQ 27,1347,2013In Vitro/Human, liver Inhibitor Concentration (50 percent kill): 138 µmol/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 6,47,1992In Vitro/Human, liver Inhibitor Concentration (10 percent kill): 70 µmol/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 6,47,1992In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 83000 mg/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 27,1347,2013In Vitro/Human, neuroblastoma Inhibitor Concentration (50 percent kill): 51400 mg/L In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. TIVIEQ 27,1347,2013In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 42700 mg/L/48H In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. TIVIEQ 27,1347,2013In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 440000 mg/L/1M In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. TIVIEQ 6,367,1992In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 290 µmol/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 6,47,1992In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 83 µmol/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 6,47,1992In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 20500 mg/L/48H In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. TIVIEQ 27,1347,2013In Vitro/paa Inhibitor Concentration Low: 392 mmol/L/44H In Vitro Toxicity Studies: Other assays TIVIEQ 27,1416,2013In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 68300 mg/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 27,1347,2013In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 262 µmol/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 6,47,1992In Vitro/Rat, liver Inhibitor Concentration (10 percent kill): 83 µmol/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 6,47,1992In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 93 gm/L/24H In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) TIVIEQ 7,111,1993In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 96 gm/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 7,111,1993In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 35.5 gm/L/24H In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) TIVIEQ 7,111,1993In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 169 gm/L/24H In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) TIVIEQ 7,111,1993In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 43.7 gm/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 7,111,1993In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 158 gm/L/24H In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ 7,111,1993Eye: Lacrimationinhalation/human lowest published toxic concentration: 10000 mg/m3 Lung, Thorax, or Respiration: Cough AGGHAR 5,1,1933Lung, Thorax, or Respiration: Other changesinhalation/human lowest published toxic concentration: 22 mg/m3 Kidney, Ureter, and Bladder: Proteinuria IAEHDW 69,255,1997inhalation/mouse Lethal concentration: >200 mg/m3/2H GTPZAB 25(11),57,1981inhalation/rabbit lowest published toxic concentration: 12 mg/m3 Eye: Conjunctiva irritation VCVGK* -,141,1984inhalation/rabbit lowest published toxic concentration: 4 mg/m3/2H Behavioral: Alteration of classical conditioning VCVGK* -,139,1984Behavioral: Muscle contraction or spasticityinhalation/rat lowest published toxic concentration: 0.004 gm/m3/2H Lung, Thorax, or Respiration: Respiratory stimulation TPKVAL 7,102,1965Gastrointestinal: Hypermotility, diarrheainhalation/rat Lethal concentration: >200 mg/m3/4H GTPZAB 25(11),57,1981Behavioral: Somnolence (general depressed activity)intramuscular/rabbit lowest published lethal dose: 5500 mg/kg Behavioral: Coma JPETAB 41,387,1931Lung, Thorax, or Respiration: Respiratory stimulationintramuscular/rabbit lowest published lethal dose: 5500 mg/kg VCVGK* -,139,1984intramuscular/rat lowest published lethal dose: 3300 mg/kg VCVGK* -,139,1984Behavioral: Somnolence (general depressed activity)intramuscular/rat lowest published lethal dose: 3300 mg/kg Behavioral: Coma JPETAB 41,387,1931Lung, Thorax, or Respiration: Respiratory stimulationintraperitoneal/monkey lowest published lethal dose: 4000 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVGK* -,140,1984Lung, Thorax, or Respiration: Chronic pulmonary edema or congestionintraperitoneal/mouse lethal dose (50 percent kill): 5614 mg/kg Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli FEPRA7 6,342,1947Blood: Changes in spleenintraperitoneal/mouse lethal dose (50 percent kill): 1700 mg/kg VCVGK* -,139,1984intraperitoneal/rabbit lowest published lethal dose: 1000 mg/kg VCVGK* -,139,1984intraperitoneal/rat lethal dose (50 percent kill): 5010 mg/kg KRKRDT 9,36,1981intravenous/mouse lethal dose (50 percent kill): 300 mg/kg VCVGK* -,139,1984intravenous/rabbit lowest published lethal dose: 5000 mg/kg VCVGK* -,139,1984Behavioral: Somnolence (general depressed activity)intravenous/rabbit lowest published lethal dose: 5 gm/kg Behavioral: Tremor JPETAB 41,387,1931Behavioral: Convulsions or effect on seizure thresholdintravenous/rat lowest published lethal dose: 2800 mg/kg VCVGK* -,139,1984intravenous/rat lethal dose (50 percent kill): 3260 mg/kg KRKRDT 9,36,1981Eye: Lacrimationocular/rabbit lowest published toxic dose: 100 pph TPKVAL 7,102,1965Eye: Conjunctiva irritationoral/cat lethal dose (50 percent kill): 2000 mg/kg VCVGK* -,139,1984oral/cat lethal dose (50 percent kill): 1650 mg/kg Kidney, Ureter, and Bladder: Other changes RMVEAG 154,137,1978Behavioral: General anestheticoral/child lowest published toxic dose: 5500 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation PGMJAO 52,598,1976Kidney, Ureter, and Bladder: Other changesoral/Dog lethal dose (50 percent kill): 5500 mg/kg Kidney, Ureter, and Bladder: Other changes RMVEAG 154,137,1978Behavioral: Somnolence (general depressed activity)oral/guinea pig lethal dose (50 percent kill): 6610 mg/kg Gastrointestinal: Other changes JIHTAB 23,259,1941Kidney, Ureter, and Bladder: Other changesoral/guinea pig lethal dose (50 percent kill): 6600 mg/kg VCVGK* -,139,1984Behavioral: Convulsions or effect on seizure thresholdoral/human lowest published lethal dose: 786 mg/kg Behavioral: Coma EJTXAZ 9,373,1976Gastrointestinal: Hypermotility, diarrheaBehavioral: Headacheoral/human lowest published lethal dose: 398 mg/kg Gastrointestinal: Nausea or vomiting SMEZA5 26(2),48,1983Liver: Other changesoral/human lowest published lethal dose: 1.43 mL/kg APLMAS 129,e81,2005Brain and Coverings: Recordings from specific areas of CNSoral/man lowest published toxic dose: 24 gm/kg JTCTDW 38,445,2000Brain and Coverings: Other degenerative changesBrain and Coverings: Other degenerative changesoral/man lowest published toxic dose: 24 gm/kg Behavioral: Ataxia JTCTDW 38,445,2000Behavioral: ComaBrain and Coverings: Recordings from specific areas of CNSoral/man lowest published toxic dose: 24 gm/kg Eye: Mydriasis (pupilliary dilation) JTCTDW 38,445,2000Lung, Thorax, or Respiration: Other changesPeripheral Nerve and Sensation: Sensory change involving peripheral nerveoral/man lowest published toxic dose: 15 gm/kg Gastrointestinal: Ulceration or bleeding from small intestine AEMED3 20,208,1991Kidney, Ureter, and Bladder: Renal function tests depressedPeripheral Nerve and Sensation: Sensory change involving peripheral nerveoral/man lowest published toxic dose: 1195 mg/kg AEMED3 20,208,1991Kidney, Ureter, and Bladder: Renal function tests depressedBehavioral: Comaoral/man lowest published toxic dose: 16 gm/kg Kidney, Ureter, and Bladder: Renal function tests depressed HETOEA 9,317,1990Nutritional and Gross Metabolic: Changes in: Metabolic acidosisoral/mouse lethal dose (50 percent kill): 5500 mg/kg GISAAA 32(3),31,1967oral/rat lethal dose (50 percent kill): 4700 mg/kg VCVGK* -,139,1984Brain and Coverings: Other degenerative changesoral/rat lowest published toxic dose: 1110 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition VCVGK* -,139,1984Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)Brain and Coverings: Other degenerative changesoral/rat lowest published toxic dose: 5000 mg/kg Behavioral: Tetany VCVGK* -,139,1984Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesBrain and Coverings: Increased intracranial pressureoral/rat lowest published toxic dose: 1000 mg/kg Liver: Other changes VCVGK* -,139,1984Kidney, Ureter, and Bladder: Other changesKidney, Ureter, and Bladder: Changes in both tubules and glomerulioral/rat lowest published toxic dose: 2 gm/kg Kidney, Ureter, and Bladder: Other changes in urine composition JTCTDW 46,402,2008Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsoral/rat lowest published toxic dose: 120 mg/kg Blood: Changes in bone marrow not included in above VCVGK* -,140,1984skin/rabbit lethal dose (50 percent kill): 9530 µL/kg 34ZIAG -,731,1969Behavioral: Convulsions or effect on seizure thresholdsubcutaneous/cat lowest published lethal dose: 2 gm/kg Behavioral: Muscle weakness AGGHAR 5,1,1933Blood: Other changessubcutaneous/cat lowest published lethal dose: 2000 mg/kg VCVGK* -,139,1984subcutaneous/guinea pig lowest published lethal dose: 5000 mg/kg VCVGK* -,139,1984subcutaneous/mouse lethal dose (50 percent kill): 2700 mg/kg VCVGK* -,139,1984subcutaneous/mouse lowest published lethal dose: 2700 mg/kg BJIMAG 1,207,1944subcutaneous/mouse lowest published toxic dose: 5000 mg/kg Kidney, Ureter, and Bladder: Renal function tests depressed EKFAE9 55,21,1992subcutaneous/rabbit lethal dose (50 percent kill): 19500 mg/kg VCVGK* -,139,1984subcutaneous/rat lethal dose (50 percent kill): 2800 mg/kg NPIRI* 1,49,1974subcutaneous/rat lowest published toxic dose: 3000 mg/kg Kidney, Ureter, and Bladder: Renal function tests depressed EKFAE9 55,21,1992Behavioral: Somnolence (general depressed activity)unreported route/guinea pig lethal dose (50 percent kill): 11150 mg/kg Behavioral: Excitement GISAAA 33(3),16,1968Gastrointestinal: Nausea or vomitingCardiac: Change in rateunreported route/human lowest published lethal dose: 70 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema VCVGK* -,140,1984Liver: Other changesunreported route/man lowest published lethal dose: 1637 mg/kg 85DCAI 2,73,1970Behavioral: Somnolence (general depressed activity)unreported route/mouse lethal dose (50 percent kill): 8050 mg/kg Behavioral: Excitement GISAAA 33(3),16,1968Gastrointestinal: Nausea or vomitingBehavioral: Somnolence (general depressed activity)unreported route/rabbit lethal dose (50 percent kill): 5017 mg/kg Behavioral: Excitement GISAAA 33(3),16,1968Gastrointestinal: Nausea or vomitingBehavioral: Somnolence (general depressed activity)unreported route/rat lethal dose (50 percent kill): 13 gm/kg Behavioral: Excitement GISAAA 33(3),16,1968Gastrointestinal: Nausea or vomitingOther Multiple Dose Data and ReferencesRoute/Organism Dose Effect ReferenceBrain and Coverings: Other degenerative changesinhalation/cat lowest published toxic concentration: 500000 mg/m3/6H/5D- intermittent VCVGK* -,140,1994Behavioral: General anestheticEye: Conjunctiva irritationinhalation/guinea pig lowest published toxic concentration: 1 mg/m3/122D- intermittent Behavioral: Irritability VCVGK* -,140,1994Lung, Thorax, or Respiration: Coughinhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/7D- intermittent Lung, Thorax, or Respiration: Respiratory depression TPKVAL 7,102,1965Behavioral: Excitementinhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/45D- intermittent TPKVAL 7,102,1965Liver: Liver function tests impairedinhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/76D- intermittent Behavioral: Aggression TPKVAL 7,102,1965inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/106D- intermittent Behavioral: Somnolence (general depressed activity) TPKVAL 7,102,1965inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/122D- intermittent Kidney, Ureter, and Bladder: Urine volume increased TPKVAL 7,102,1965inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/61D- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 7,102,1965Brain and Coverings: Other degenerative changesinhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/183D- intermittent Vascular: Structural changes in vessels TPKVAL 7,102,1965Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchiVascular: BP lowering not characterized in autonomic sectioninhalation/guinea pig lowest published toxic concentration: 1 mg/m3/154D- intermittent Lung, Thorax, or Respiration: Other changes VCVGK* -,140,1994Liver: Other changesinhalation/human lowest published toxic concentration: 140 mg/m3/30D- intermittent Lung, Thorax, or Respiration: Cough VCVGK* -,140,1994Cardiac: Other changesinhalation/mammal (species unspecified) lowest published toxic concentration: 20 mg/m3/5Y- intermittent Vascular: Other changes VCVGK* -,141,1994Kidney, Ureter, and Bladder: Other changesinhalation/mammal (species unspecified) lowest published toxic concentration: 256 mg/m3/28D- intermittent Liver: Liver function tests impaired VCVGK* -,140,1994Brain and Coverings: Other degenerative changesinhalation/monkey lowest published toxic concentration: 500000 mg/m3/6H/5D- intermittent VCVGK* -,140,1994Behavioral: General anestheticVascular: BP lowering not characterized in autonomic sectioninhalation/mouse lowest published toxic concentration: 1 mg/m3/154D- intermittent Lung, Thorax, or Respiration: Other changes VCVGK* -,140,1994Liver: Other changesinhalation/mouse lowest published toxic concentration: 10 mg/m3/122D- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,140,1994Eye: Conjunctiva irritationinhalation/mouse lowest published toxic concentration: 1 mg/m3/122D- intermittent Behavioral: Irritability VCVGK* -,140,1994Lung, Thorax, or Respiration: CoughBehavioral: Aggressioninhalation/mouse lowest published toxic concentration: 0.003 gm/m3/61D- intermittent Vascular: Other changes TPKVAL 7,102,1965Lung, Thorax, or Respiration: Respiratory stimulationinhalation/mouse lowest published toxic concentration: 0.003 gm/m3/30D- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 7,102,1965Lung, Thorax, or Respiration: Emphysemainhalation/mouse lowest published toxic concentration: 0.003 gm/m3/122D- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TPKVAL 7,102,1965Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEye: Corneal damageinhalation/rabbit lowest published toxic concentration: 12 mg/m3/8H/90D- intermittent Eye: Other eye effects TXAPA9 16,646,1970Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldinhalation/rat lowest published toxic concentration: 120 mg/m3/8D- intermittent Eye: Corneal damage VCVGK* -,140,1994Cardiac: Other changesinhalation/rat lowest published toxic concentration: 198 mg/m3/4H/122D- intermittent Liver: Liver function tests impaired VCVGK* -,140,1994Kidney, Ureter, and Bladder: Other changesBrain and Coverings: Changes in brain weightinhalation/rat lowest published toxic concentration: 8400 µg/m3/24H/12W- continuous Kidney, Ureter, and Bladder: Urine volume decreased or anuria GISAAA 39(9),106,1974Nutritional and Gross Metabolic: Weight loss or decreased weight gainEye: Corneal damageinhalation/rat lowest published toxic concentration: 12 mg/m3/8H/90D- intermittent TXAPA9 16,646,1970Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEye: Conjunctiva irritationinhalation/rat lowest published toxic concentration: 1 mg/m3/122D- intermittent Behavioral: Irritability VCVGK* -,140,1994Lung, Thorax, or Respiration: CoughVascular: BP lowering not characterized in autonomic sectioninhalation/rat lowest published toxic concentration: 1 mg/m3/154D- intermittent Lung, Thorax, or Respiration: Other changes VCVGK* -,140,1994Liver: Other changesLung, Thorax, or Respiration: Other changesinhalation/rat lowest published toxic concentration: 1 mg/m3/32W- intermittent Liver: Liver function tests impaired TPKVAL 7,102,1965Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)Behavioral: Excitementinhalation/rat lowest published toxic concentration: 0.003 gm/m3/7D- intermittent TPKVAL 7,102,1965Vascular: Other changesEye: Conjunctiva irritationinhalation/rat lowest published toxic concentration: 0.003 gm/m3/14D- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi TPKVAL 7,102,1965Lung, Thorax, or Respiration: Respiratory stimulationPeripheral Nerve and Sensation: Recording from peripheral motor nerveinhalation/rat lowest published toxic concentration: 0.003 gm/m3/61D- intermittent Behavioral: Somnolence (general depressed activity) TPKVAL 7,102,1965Liver: Liver function tests impairedinhalation/rat lowest published toxic concentration: 0.003 gm/m3/76D- intermittent Behavioral: Aggression TPKVAL 7,102,1965inhalation/rat lowest published toxic concentration: 0.003 gm/m3/106D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TPKVAL 7,102,1965Brain and Coverings: Other degenerative changesinhalation/rat lowest published toxic concentration: 0.003 gm/m3/228D- intermittent Vascular: Structural changes in vessels TPKVAL 7,102,1965Lung, Thorax, or Respiration: Emphysemainhalation/rat lowest published toxic concentration: 0.02 gm/m3/2W- intermittent Behavioral: Aggression TPKVAL 7,102,1965inhalation/rat lowest published toxic concentration: 0.02 gm/m3/20D- intermittent Behavioral: Somnolence (general depressed activity) TPKVAL 7,102,1965Eye: Conjunctiva irritationinhalation/rat lowest published toxic concentration: 0.02 gm/m3/4W- intermittent TPKVAL 7,102,1965Vascular: Other changesLung, Thorax, or Respiration: Emphysemainhalation/rat lowest published toxic concentration: 0.02 gm/m3/153D- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TPKVAL 7,102,1965Blood: Changes in spleeninhalation/rat lowest published toxic concentration: 0.02 gm/m3/45D- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 7,102,1965Blood: Changes in bone marrow not included in aboveinhalation/rat lowest published toxic concentration: 0.02 gm/m3/61D- intermittent TPKVAL 7,102,1965Blood: Changes in other cell count (unspecified)oral/monkey lowest published toxic dose: 5751 gm/kg/22W- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TXAPA9 15,624,1969oral/mouse lowest published toxic dose: 88720 mg/kg/8D- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,141,1984Liver: Hepatitis (hepatocellular necrosis), zonaloral/mouse lowest published toxic dose: 546 gm/kg/13W- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) NTPTR* NTP-TR-413,1993Nutritional and Gross Metabolic: Weight loss or decreased weight gainLiver: Hepatitis (hepatocellular necrosis), zonaloral/mouse lowest published toxic dose: 1081 gm/kg/2Y- continuous NTPTR* NTP-TR-413,1993Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)oral/mouse lowest published toxic dose: 29.4 gm/kg/7D- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 81,100,1985oral/mouse lowest published toxic dose: 117.6 gm/kg/14D- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 81,100,1985oral/mouse lowest published toxic dose: 82.3 gm/kg/14W- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 81,100,1985Skin and Appendages: Other: Hairoral/mouse lowest published toxic dose: 15000 mg/kg/10D- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB85-105385Liver: Changes in liver weightKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)oral/mouse lowest published toxic dose: 294000 mg/kg/15W- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct NTIS** #PB86177383Nutritional and Gross Metabolic: Weight loss or decreased weight gainKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)oral/rabbit lowest published toxic dose: 28000 mg/kg/14D- intermittent NTIS** #PB91-211219Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldoral/rat lowest published toxic dose: 25000 mg/kg/10D- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB95-274528Kidney, Ureter, and Bladder: Proteinuriaoral/rat lowest published toxic dose: 10.9 gm/kg/7D- intermittent Nutritional and Gross Metabolic: Changes in: Ca PHMREP 43,89,2001Nutritional and Gross Metabolic: Changes in: Poral/rat lowest published toxic dose: 18.2 gm/kg/1Y- continuous Kidney, Ureter, and Bladder: Other changes in urine composition TXAPA9 228,165,2008Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldoral/rat lowest published toxic dose: 109.5 gm/kg/1Y- continuous Behavioral: Fluid intake TXAPA9 228,165,2008Kidney, Ureter, and Bladder: Urine volume increasedBehavioral: Food intake (animal)oral/rat lowest published toxic dose: 146 gm/kg/1Y- continuous TXAPA9 228,165,2008Nutritional and Gross Metabolic: Weight loss or decreased weight gainKidney, Ureter, and Bladder: Other changes in urine compositionoral/rat lowest published toxic dose: 42 mg/kg/8W- continuous TOXID9 -,103,2009Kidney, Ureter, and Bladder: Other changesKidney, Ureter, and Bladder: Urine volume increasedoral/rat lowest published toxic dose: 5.25 gm/kg/1W- continuous Kidney, Ureter, and Bladder: Proteinuria FCTOD7 48,1013,2010Kidney, Ureter, and Bladder: Other changes in urine compositionKidney, Ureter, and Bladder: Renal function tests depressedoral/rat lowest published toxic dose: 21 gm/kg/4W- continuous Kidney, Ureter, and Bladder: Other changes FCTOD7 48,1013,2010Nutritional and Gross Metabolic: Changes in: Caoral/rat lowest published toxic dose: 15.75 gm/kg/3W- continuous Kidney, Ureter, and Bladder: Other changes TXCYAC 290,82,2011Kidney, Ureter, and Bladder: Renal function tests depressedoral/rat lowest published toxic dose: 21 mL/kg/28D- continuous Kidney, Ureter, and Bladder: Other changes in urine composition JOETD7 140,234,2012Kidney, Ureter, and Bladder: Other changesKidney, Ureter, and Bladder: Renal function tests depressedoral/rat lowest published toxic dose: 21 gm/kg/28D- continuous Kidney, Ureter, and Bladder: Other changes JOETD7 144,160,2012Nutritional and Gross Metabolic: Changes in: CaKidney, Ureter, and Bladder: Urine volume decreased or anuriaoral/rat lowest published toxic dose: 26.25 gm/kg/28D- continuous Kidney, Ureter, and Bladder: Other changes in urine composition JOETD7 195,275,2017Nutritional and Gross Metabolic: Weight loss or decreased weight gainKidney, Ureter, and Bladder: Changes in kidney weightoral/rat lowest published toxic dose: 33750 mg/kg/15D- intermittent NTIS** #PB85-105385Reproductive: Maternal effects: Uterus, cervix, vaginaoral/rat lowest published toxic dose: 18750 mg/kg/15D- intermittent Kidney, Ureter, and Bladder: Other changes NTIS** #PB85-105385Liver: Other changesoral/rat lowest published toxic dose: 14 mL/kg/2W- continuous Liver: Changes in liver weight JOUOD4 13,13,1991Kidney, Ureter, and Bladder: Changes in bladder weightBehavioral: Fluid intakeoral/rat lowest published toxic dose: 438 gm/kg/2Y- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) FCTXAV 3,229,1965Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldKidney, Ureter, and Bladder: Changes in bladder weightoral/rat lowest published toxic dose: 85230 mg/kg/90D- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) DCTODJ 13,43,1990Nutritional and Gross Metabolic: Changes in: PNutritional and Gross Metabolic: Changes in: Caoral/rat lowest published toxic dose: 12 mL/kg/6D- intermittent Nutritional and Gross Metabolic: Changes in: P TXAPA9 39,543,1977Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphatasesKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)oral/rat lowest published toxic dose: 26150 mg/kg/10D- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) DCTODJ 13,43,1990Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: DehydrogenasesReproductive: Paternal effects: Testes, epididymis, sperm ductunreported route/rat lowest published toxic dose: 9.1 mg/kg/26W- intermittent VCVGK* -,141,1994Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsReviewsOrganization Standard ReferenceAmerican Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-ceiling concentration 100 mg/m3 (aerosol) DTLVS* TLV/BEI,2013American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-Not classifiable as a human carcinogen DTLVS* TLV/BEI,2013TOXICOLOGY REVIEW AJMEAZ 38,409,1965TOXICOLOGY REVIEW FAATDF 13,747,1989TOXICOLOGY REVIEW REPTED 8,99,1994TOXICOLOGY REVIEW MUREAV 566,21,2004TOXICOLOGY REVIEW MUREAV 543,201,2003TOXICOLOGY REVIEW JEMME* 15,653,1997TOXICOLOGY REVIEW ARTODN 78,671,2004TOXICOLOGY REVIEW AINCM* 7,63,2006TOXICOLOGY REVIEW ENTOX* -,287,2005TOXICOLOGY REVIEW REPTED 25,192,2008TOXICOLOGY REVIEW FSINDR 155,179,2005TOXICOLOGY REVIEW HUTOX* -,623,1996TOXICOLOGY REVIEW AIRMJ* 18,114,1999TOXICOLOGY REVIEW FESTAS 90,911,2008TOXICOLOGY REVIEW REPTED 34,298,2012TOXICOLOGY REVIEW FCTOD7 55,596,2013TOXICOLOGY REVIEW REPTED 58,252,2015TOXICOLOGY REVIEW RTOPDW 58,395,2010TOXICOLOGY REVIEW TOLED5 278,66,2017TOXICOLOGY REVIEW VETODR ,197,2018TOXICOLOGY REVIEW VETODR ,215,2018Standards and RegulationsOrganization Standard ReferenceEnvironmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES Cancelled RBREV* -,308,1998Mine Safety and Health Administration (MSHA) STANDARD-air time-weighted average 10 mg/m3 (particulate) DTLWS* 3,19,1973Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLVOccupational Exposure Limit-AUSTRALIA time-weighted average 10 mg/m3 (aerosol), JUL2008Occupational Exposure Limit-AUSTRALIA time-weighted average 20 ppm (52 mg/m3), short term exposure limit 40 ppm (104 mg/m3) (vapor), JUL2008Occupational Exposure Limit-AUSTRIA MAK-TMW 10 ppm (26 mg/m3);KZW 20 ppm (52 mg/m3), skin, 2007Occupational Exposure Limit-BELGIUM time-weighted average 20 ppm (52 mg/m3), MAR2002Occupational Exposure Limit-BELGIUM short term exposure limit 40 ppm (104 mg/m3), Skin, MAR2002Occupational Exposure Limit-DENMARK time-weighted average 10 mg/m3 (aerosol), MAY2011Occupational Exposure Limit-DENMARK time-weighted average 10 ppm (26 mg/m3), skin, MAY2011Occupational Exposure Limit-EC time-weighted average 52 mg/m3 (20 ppm);short term exposure limit 104 mg/m3 (40 ppm), skin, JUN2000Occupational Exposure Limit-FINLAND time-weighted average 20 ppm (50 mg/m3), short term exposure limit 40 ppm (100 mg/m3), skin, NOV2011Occupational Exposure Limit-FRANCE VME 20 ppm (52 mg/m3), VLE 40 ppm (104 mg/m3), Skin, FEB2006Occupational Exposure Limit-GERMANY MAK 10 ppm (26 mg/m3), 2011Occupational Exposure Limit-HUNGARY time-weighted average 52 mg/m3, short term exposure limit 104 mg/m3, Skin, SEP2000Occupational Exposure Limit-ICELAND time-weighted average 10 ppm (26 mg/m3), aerosol, NOV2011Occupational Exposure Limit-KOREA ceiling concentration 50 ppm (125 mg/m3), 2006Occupational Exposure Limit-MEXICO time-weighted average 50 ppm (125 mg/m3) (vapor), 2004Occupational Exposure Limit-MEXICO peak 100 mg/m3, 2004Occupational Exposure Limit-NEW ZEALAND ceiling concentration 50 ppm (127 mg/m3) (vapour and mist), JAN2002Occupational Exposure Limit-NORWAY time-weighted average 25 ppm (63 mg/m3), JAN1999Occupational Exposure Limit-PERU short term exposure limit 39 ppm (100 mg/m3), JUL2005Occupational Exposure Limit-POLAND MAC(time-weighted average) 15 mg/m3, MAC(short term exposure limit) 50 mg/m3, JAN1999Occupational Exposure Limit-RUSSIA time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JUN2003Occupational Exposure Limit-SWEDEN time-weighted average 10 ppm (25 mg/m3);short term exposure limit 20 ppm (50 mg/m3), Skin, JUN2005Occupational Exposure Limit-SWITZERLAND MAK-week 10 ppm (26 mg/m3), KZG-week 20 ppm (52 mg/m3), skin, JAN2011Occupational Exposure Limit-THE NETHERLANDS MAC-TGG 10 mg/m3 (drops), 2003Occupational Exposure Limit-THE NETHERLANDS MAC-TGG 52 mg/m3 (fume), 2003Occupational Exposure Limit-UNITED KINGDOM time-weighted average 10 mg/m3 (particulate), skin, OCT2007Occupational Exposure Limit-UNITED KINGDOM time-weighted average 20 ppm (52 mg/m3);short term exposure limit 40 ppm (104 mg/m3) (vapor), skin, OCT2007NIOSH Documentation and SurveillanceOrganization Standard ReferenceNational Occupational Exposure Survey 1983 Hazard Code 32385; Number of Industries 340; Total Number of Facilities 102395; Number of Occupations 214; Total Number of Employees Exposed 1511087; Total Number of Female Employees Exposed 446607National Occupational Hazard Survey 1974 Hazard Code 32385; Number of Industries 308; Total Number of Facilities 69314; Number of Occupations 174; Total Number of Employees Exposed 743782Status in Federal AgenciesOrganization ReferenceATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101108/AS)EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunctionEPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. lossEPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; N crassa-aneuploidyEPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames testEPA TSCA Section 8(b) CHEMICAL INVENTORYEPA TSCA Section 8(d) unpublished health/safety studiesEPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9100;8EHQ-0892-9252EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001NCI Carcinogenesis Studies (feed);no evidence:mouseNIOSH Analytical Method, 1994: Ethylene glycol, 5500NIOSH Analytical Method, 1996: Glycols, 5523On EPA IRIS databasePage last reviewed: November 16, 2018Content source: National Institute for Occupational Safety and Health* SyndicateRegistry of Toxic Effects of Chemical Substances (RTECS)* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS DatabaseFollow NIOSH* YouTubeNIOSH Homepage* Workplace Safety & Health Topics* Publications and Products* Programs* Contact NIOSH* About CDC* Contact Us* 800-232-4636Facebook Twitter Instagram LinkedIn Youtube Pinterest SnapchatFacebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat RSS* CONTACT CDCContact UsCall 800-232-4636Email Us* ABOUT CDC+ About CDC+ Jobs+ Funding* POLICIES+ Accessibility+ External Links+ Privacy+ Policies+ Web Policies+ No Fear Act+ FOIA+ OIG+ No Fear Act+ Nondiscrimination+ Vulnerability Disclosure Policy+ CDC Archive+ Public Health Publications+ HHS.gov+ USA.gov* CONNECT WITH US+ Youtube+ Snapchat* LANGUAGES+ Español+ 繁體中文+ Tiếng Việt+ 한국어+ Tagalog+ 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