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          The National Institute for Occupational Safety and Health (NIOSH)
         1. Registry of Toxic Effects of Chemical Substances (RTECS)
      Ether, chloromethyl methyl
            Related Pages
                RTECS #
                  KN6650000
                CAS #
                  107-30-2
                  See: NMAM or OSHA Methods
                Updated
                  December 2018
                Molecular Weight
                  80.52
                Molecular Formula
                  C2H5ClO
                Synonyms
                  Chlordimethylether (Czech)
                  Chloromethyl methyl ether
                  Chloromethyl methyl ether (ACGIH:OSHA)
                  Chloromethyl methyl ether, technical grade
                  CMME
                  Dimethylchloroether
                  Ether methylique monochlore (French)
                  Ether, dimethyl chloro
                  Methoxychloromethane
                  Methylchloromethyl ether
                  Monochlorodimethyl ether
                  RCRA waste number U046
        Mutation Data and Reference
          System Test              Route/Organism/Tissue  Dose     Reference         
          DNA inhibition           lymphocyte/human       5 mL/L   CALEDQ 13,213,1981
          morphological transform  embryo/hamster         10 mg/L  AETODY 1,241,1980 
          Tumorigenic Data and References
            Route/Organism      Dose                                                            Effect                                                             Reference          
                                                                                                Tumorigenic: Equivocal tumorigenic agent by RTECS criteria                            
            inhalation/hamster  lowest published toxic concentration: 1 ppm/6H/90D                                                                                 AEHLAU 30,70,1975  
                                                                                                Lung, Thorax, or Respiration: Tumors                                                  
                                                                                                Tumorigenic: Equivocal tumorigenic agent by RTECS criteria                            
            inhalation/hamster  lowest published toxic concentration: 1 ppm/852D- intermittent  Lung, Thorax, or Respiration: Bronchogenic carcinoma               HPV174 -,-,2003    
                                                                                                Tumorigenic: Increased incidence of tumors in susceptible strains                     
                                                                                                Tumorigenic: Neoplastic by RTECS criteria                                             
            inhalation/mouse    lowest published toxic concentration: 2 ppm/21W- intermittent   Lung, Thorax, or Respiration: Tumors                               HPV174 -,-,2003    
                                                                                                Tumorigenic: Increased incidence of tumors in susceptible strains                     
                                                                                                Tumorigenic: Equivocal tumorigenic agent by RTECS criteria                            
            inhalation/mouse    lowest published toxic concentration: 2 ppm/82D- intermittent                                                                      AEHLAU 22,663,1971 
                                                                                                Lung, Thorax, or Respiration: Tumors                                                  
                                                                                                Tumorigenic: Equivocal tumorigenic agent by RTECS criteria                            
            inhalation/rat      lowest published toxic concentration: 1 ppm/6H/72W              Lung, Thorax, or Respiration: Tumors                               AEHLAU 30,70,1975  
                                                                                                Endocrine: Tumors                                                                     
                                                                                                Tumorigenic: Equivocal tumorigenic agent by RTECS criteria                            
            inhalation/rat      lowest published toxic concentration: 1 ppm/852D- intermittent  Lung, Thorax, or Respiration: Bronchogenic carcinoma               HPV174 -,-,2003    
                                                                                                Tumorigenic: Increased incidence of tumors in susceptible strains                     
                                                                                                Tumorigenic: Equivocal tumorigenic agent by RTECS criteria                            
            subcutaneous/mouse  lowest published toxic dose: 5 ml/kg                            Lung, Thorax, or Respiration: Tumors                               HPV174 -,-,2003    
                                                                                                Tumorigenic: Increased incidence of tumors in susceptible strains                     
                                                                                                Tumorigenic: Neoplastic by RTECS criteria                                             
            subcutaneous/mouse  lowest published toxic dose: 312 mg/kg/26W- intermittent                                                                           JNCIAM 46,143,1971 
                                                                                                Tumorigenic: Tumors at site of application                                            
                                                                                                Tumorigenic: Neoplastic by RTECS criteria                                             
            subcutaneous/mouse  toxic dose: 852 mg/kg/71W- intermittent                                                                                            JNCIAM 48,1431,1972
                                                                                                Tumorigenic: Tumors at site of application                                            
                                                                                                Tumorigenic: Equivocal tumorigenic agent by RTECS criteria                            
            subcutaneous/mouse  toxic dose: 125 mg/kg                                                                                                              TXAPA9 15,92,1969  
                                                                                                Lung, Thorax, or Respiration: Tumors                                                  
            Acute Toxicity Data and References
              Route/Organism      Dose                                                    Effect                                                               Reference        
                                                                                          Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion                   
              inhalation/hamster  lethal concentration (50 percent kill): 65 ppm/7H                                                                            AEHLAU 30,61,1975
                                                                                          Blood: Hemorrhage                                                                     
                                                                                          Lung, Thorax, or Respiration: Acute pulmonary edema                                   
              inhalation/hamster  lethal concentration (50 percent kill): 212.5 mg/m3/7H                                                                       VCVGK* -,278,1994
                                                                                          Lung, Thorax, or Respiration: Other changes                                           
              inhalation/mouse    Lowest published lethal concentration: 330 mg/m3/2H                                                                          VCVGK* -,278,1994
              inhalation/mouse    lethal concentration (50 percent kill): 1030 mg/m3/2H                                                                        85GMAT -,89,1982 
              inhalation/rabbit   lowest published toxic concentration: 9 mg/m3           Lung, Thorax, or Respiration: Cough                                  VCVGK* -,278,1994
              inhalation/rabbit   lowest published toxic concentration: 27 mg/m3          Behavioral: Alteration of classical conditioning                     VCVGK* -,278,1994
                                                                                          Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion                   
              inhalation/rat      lethal concentration (50 percent kill): 55 ppm/7H                                                                            AEHLAU 30,61,1975
                                                                                          Blood: Hemorrhage                                                                     
                                                                                          Lung, Thorax, or Respiration: Acute pulmonary edema                                   
              inhalation/rat      lethal concentration (50 percent kill): 179.8 mg/m3/7H                                                                       VCVGK* -,278,1994
                                                                                          Lung, Thorax, or Respiration: Other changes                                           
                                                                                          Lung, Thorax, or Respiration: Acute pulmonary edema                                   
              inhalation/rat      lethal concentration (50 percent kill): 55 ppm/7H                                                                            HPV174 -,-,2003  
                                                                                          Lung, Thorax, or Respiration: Changes in lung weight                                  
              oral/rat            lowest published lethal dose: 1000 mg/kg                                                                                     HPV174 -,-,2003  
              oral/rat            lethal dose (50 percent kill): 223 mg/kg                                                                                     HPV174 -,-,2003  
              Other Multiple Dose Data and References
                Route/Organism     Dose                                                                Effect                                                                               Reference        
                inhalation/mouse   lowest published toxic concentration: 6 mg/m3/130D- intermittent    Lung, Thorax, or Respiration: Tumors                                                 VCVGK* -,278,1994
                                                                                                       Lung, Thorax, or Respiration: Other changes                                                           
                inhalation/rabbit  lowest published toxic concentration: 3 mg/m3/5H/90D- intermittent  Liver: Other changes                                                                 VCVGK* -,278,1994
                                                                                                       Nutritional and Gross Metabolic: Weight loss or decreased weight gain                                 
                                                                                                       Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi                   
                inhalation/rat     lowest published toxic concentration: 32.7 mg/m3/30D- intermittent                                                                                       VCVGK* -,278,1994
                                                                                                       Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field                                 
                                                                                                       Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi                   
                inhalation/rat     lowest published toxic concentration: 3.27 mg/m3/130W- continuous                                                                                        VCVGK* -,278,1994
                                                                                                       Skin and Appendages: Tumors                                                                           
                                                                                                       Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi                   
                inhalation/rat     lowest published toxic concentration: 10 ppm/3D- intermittent       Lung, Thorax, or Respiration: Other changes                                          HPV174 -,-,2003  
                                                                                                       Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field                                 
                Reviews
                  Organization                                                       Standard                                          Reference           
                  American Conference of Governmental Industrial Hygienists (ACGIH)  Threshold Limit Value-Control as low as possible  DTLVS* TLV/BEI,2013 
                  American Conference of Governmental Industrial Hygienists (ACGIH)  Threshold Limit Value-Suspected human carcinogen  DTLVS* TLV/BEI,2013 
                  International Agency for Research on Cancer (IARC)                 Cancer Review:Human Sufficient Evidence           IMEMDT 4,239,1974   
                  International Agency for Research on Cancer (IARC)                 Cancer Review:Animal Sufficient Evidence          IMEMDT 4,239,1974   
                  International Agency for Research on Cancer (IARC)                 Cancer Review:Animal Limited Evidence             IMEMDT 100F,306,2012
                  International Agency for Research on Cancer (IARC)                 Cancer Review:Human Sufficient Evidence           IMEMDT 100F,306,2012
                  International Agency for Research on Cancer (IARC)                 Cancer Review:Group 1                             IMSUDL 7,131,1987   
                  International Agency for Research on Cancer (IARC)                 Cancer Review:Group 1                             IMEMDT 100F,306,2012
                  TOXICOLOGY REVIEW                                                                                                    EESADV 1,289,1977   
                  TOXICOLOGY REVIEW                                                                                                    MUREAV 566,21,2004  
                  TOXICOLOGY REVIEW                                                                                                    FCTOD7 44,1699,2006 
                  TOXICOLOGY REVIEW                                                                                                    MUREAV 584,1,2005   
                  TOXICOLOGY REVIEW                                                                                                    MUREAV 733,39,2012  
                  TOXICOLOGY REVIEW                                                                                                    MUREAV 802,1,2016   
                  TOXICOLOGY REVIEW                                                                                                    RTOPDW 54,247,2009  
                  Standards and Regulations
                    Organization                                                                                    Standard                                            Reference               
                    Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;                                                                                       
                    Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV                                                                                                           
                    Occupational Exposure Limit-AUSTRALIA                                                           Carcinogen, JUL2008                                                         
                    Occupational Exposure Limit-JAPAN                                                               2A carc, MAY2012                                                            
                    Occupational Exposure Limit-RUSSIA                                                              short term exposure limit 0.5 mg/m3, Skin, JUN2003                          
                    Occupational Exposure Limit-SWEDEN                                                              Group A Carcinogen, JUN2005                                                 
                    Occupational Exposure Limit-SWITZERLAND                                                         carc 1, JAN2011                                                             
                    Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)  see Code of Federal Regulations (CFR) 29,1926.1108  CFRGBR 29,1926.55,1994  
                    Occupational Safety and Health Administration (OSHA)-cancer suspect agent                                                                           CFRGBR 29,1910.1006,1987
                    NIOSH Documentation and Surveillance
                      Organization                                                                                                               Standard                                                       Reference               
                      National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROMETHYL METHYL ETHER-air  Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1006  NIOSH* DHHS #92-100,1992
                      Status in Federal Agencies
                        Organization                                                           Reference
                        EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat           
                        EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE                     
                        EPA TSCA Section 8(b) CHEMICAL INVENTORY                                        
                        EPA TSCA Section 8(d) unpublished health/safety studies                         
                        EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001                       
                        NTP 14th Report on Carcinogens,2016:Known to be a human carcinogen              
                        On EPA IRIS database                                                            
                        OSHA ANALYTICAL METHOD #10                                                      
                      Page last reviewed: November 16, 2018
                        Content source: National Institute for Occupational Safety and Health
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