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Original site: www.cdc.gov/niosh-rtecs/GL5140C8.html | RestoredCDC.org is an independent project, not affiliated with CDC or any federal entity. Visit CDC.gov for free official information. Due to archival on January 6, 2025, recent outbreak data is unavailable. Videos are not restored. Access data.restoredcdc.org for restored data. Use of this site implies acceptance of this disclaimer.[More]About Us Report Bug Compare ContentSkip directly to page optionsThe National Institute for Occupational Safety and Health (NIOSH)Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting PeopleSearchSearch Menu Navigation Menu× NIOSHNIOSH All CDCSubmit* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS Database* The National Institute for Occupational Safety and Health (NIOSH) HomeThe National Institute for Occupational Safety and Health (NIOSH)1. Registry of Toxic Effects of Chemical Substances (RTECS)CopperRelated PagesRTECS #GL5325000CAS #7440-50-8; 72514-83-1See: NMAM or OSHA MethodsUpdatedMarch 2019Molecular Weight63.54Molecular FormulaCuSynonyms1721 GoldAllbri natural copperANAC 110Arwood copperBronze powderC.I. 77400C.I. Pigment Metal 2CDA 101CDA 102CDA 110CDA 122Copper (ACGIH:OSHA)Copper (metallic)Copper bronzeCopper slag-airborneCopper slag-milledCopper-airborneCopper-milledGold bronzeKafar copperM 1M 3M 4M1 (Copper)M2 (Copper)M3 (Copper)M3RM3SM4 (Copper)OFHC CuRaney copperReproductive Effects Data and ReferencesRoute/Organism Dose Effect ReferenceReproductive: Maternal effects: Uterus, cervix, vaginaintrauterine/rat 250 µg/kg (1D prior to copulation) IJEBA6 19,1124,1981Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)oral/rat 152 mg/kg (22W prior to copulation) GISAAA 45(3),8,1980Reproductive: Specific developmental abnormalities: Central nervous systemoral/rat 1520 µg/kg (22W prior to copulation) Reproductive: Specific developmental abnormalities: Musculoskeletal system GISAAA 45(3),8,1980Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)oral/rat 1210 µg/kg (35W prior to copulation) GISAAA 42(8),30,1977Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)Tumorigenic Data and ReferencesRoute/Organism Dose Effect ReferenceTumorigenic: Equivocal tumorigenic agent by RTECS criteriaintrapleural/rat lowest published toxic dose: 100 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) AIHAAP 41,836,1980Lung, Thorax, or Respiration: TumorsTumorigenic: Carcinogenic by RTECS criteriaoral/mouse lowest published toxic dose: 10.080 mg/kg/12W- continuous CALEDQ 159,57,2000Lung, Thorax, or Respiration: Other changesAcute Toxicity Data and ReferencesRoute/Organism Dose Effect Referenceintraperitoneal/mouse lethal dose (50 percent kill): 0.07 mg/kg VCVN1* -,67,1998multiple/non-mammalian species lethal concentration (50 percent kill): 238 mg/m3/24H TXAPA9 197,177,2004Gastrointestinal: Hypermotility, diarrheaoral/human lowest published toxic dose: 0.01 mg/kg TOXID9 72,29,2003Gastrointestinal: Nausea or vomitingoral/human lowest published toxic dose: 120 µg/kg Gastrointestinal: Nausea or vomiting PHRPA6 73,910,1958oral/mouse lethal dose (50 percent kill): 413 mg/kg TOLED5 163,109,2006Behavioral: Food intake (animal)oral/mouse lethal dose (50 percent kill): >5000 mg/kg Gastrointestinal: Hypermotility, diarrhea TOLED5 163,109,2006Gastrointestinal: Nausea or vomitingBehavioral: Tremororal/mouse lowest published toxic dose: 108 mg/kg Gastrointestinal: Hypermotility, diarrhea TOLED5 163,109,2006Gastrointestinal: Nausea or vomitingoral/mouse lowest published toxic dose: 1080 mg/kg Kidney, Ureter, and Bladder: Other changes TOLED5 163,109,2006oral/mouse lowest published toxic dose: 158 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TOLED5 163,109,2006Kidney, Ureter, and Bladder: Changes primarily in glomerulioral/mouse lowest published toxic dose: 232 mg/kg Blood: Changes in spleen TOLED5 163,109,2006Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)oral/mouse lowest published toxic dose: 341 mg/kg Liver: Other changes TOLED5 163,109,2006oral/mouse lowest published toxic dose: 501 mg/kg Endocrine: Changes in spleen weight TOLED5 163,109,2006oral/mouse lowest published toxic dose: 736 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases TOLED5 163,109,2006oral/mouse lowest published toxic dose: 3406 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 163,109,2006Liver: Hepatitis (hepatocellular necrosis), zonalsubcutaneous/rabbit lowest published lethal dose: 375 mg/kg Liver: Other changes AJPAA4 1,117,1925Kidney, Ureter, and Bladder: Other changesTank with water/Trout lethal concentration (50 percent kill): 9.2 µg/l/96H AQUTO* 177,51,2016Other Multiple Dose Data and ReferencesRoute/Organism Dose Effect ReferenceLiver: Other changesintravenous/rabbit lowest published toxic dose: 75 mg/kg/2D- intermittent AJPAA4 1,117,1925Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldCardiac: Other changesoral/rabbit lowest published toxic dose: 3 gm/kg/60D- continuous Liver: Hepatitis (hepatocellular necrosis), zonal AJPAA4 1,117,1925Related to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldReviewsOrganization Standard ReferenceAmerican Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-time-weighted average 0.2 mg/m3 (fume) DTLVS* TLV/BEI,2013American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-time-weighted average 1 mg/m3 (dust, mist) DTLVS* TLV/BEI,2013TOXICOLOGY REVIEW TRBMAV 33,85,1975TOXICOLOGY REVIEW QURBAW 7,75,1974TOXICOLOGY REVIEW JAVMA4 164,277,1974TOXICOLOGY REVIEW IJMDAI 10,416,1974TOXICOLOGY REVIEW KOTTAM 11,1300,1975TOXICOLOGY REVIEW FOREAE 7,313,1942TOXICOLOGY REVIEW MIBUBI 9,321,1975TOXICOLOGY REVIEW PEXTAR 12,102,1969TOXICOLOGY REVIEW 85DHAX Cu,41,1977TOXICOLOGY REVIEW AMTODM 3,209,1977TOXICOLOGY REVIEW TOLED5 127,55,2002TOXICOLOGY REVIEW CREOH* 42,93,2002TOXICOLOGY REVIEW MAERE* 51,247,2001TOXICOLOGY REVIEW MUREAV 567,109,2004TOXICOLOGY REVIEW TPHSDY 23,426,2002TOXICOLOGY REVIEW CRTXB2 33,215,2003TOXICOLOGY REVIEW CBCPAI 132,269,2002TOXICOLOGY REVIEW MUREAV 613,103,2006TOXICOLOGY REVIEW MUTAEX 19,251,2004TOXICOLOGY REVIEW MUREAV 613,76,2006TOXICOLOGY REVIEW ENTOX* -,665,2005TOXICOLOGY REVIEW JJATDK 26,191,2006TOXICOLOGY REVIEW TOPADD 32(Suppl. 2),71,2004TOXICOLOGY REVIEW MUREAV 533,183,2003TOXICOLOGY REVIEW REPTED 23,260,2007TOXICOLOGY REVIEW HBTME* ,529,2007TOXICOLOGY REVIEW MUREAV 658,68,2008TOXICOLOGY REVIEW MUREAV 566,249,2004TOXICOLOGY REVIEW HTOPA* 1,595,2002TOXICOLOGY REVIEW MUREAV 674,3,2009TOXICOLOGY REVIEW MUREAV 674,36,2009TOXICOLOGY REVIEW MUREAV 674,31,2009TOXICOLOGY REVIEW MUREAV 674,73,2009TOXICOLOGY REVIEW MUREAV 667,82,2009TOXICOLOGY REVIEW MUTAEX 23,241,2008TOXICOLOGY REVIEW CEXPB9 36,88,2009TOXICOLOGY REVIEW NEUCL* 23,485,2005TOXICOLOGY REVIEW NBREV* 5,1,1981TOXICOLOGY REVIEW MUREAV 690,71,2010TOXICOLOGY REVIEW MUTAEX 26,205,2011TOXICOLOGY REVIEW NRTXDN 33,178,2012TOXICOLOGY REVIEW REPTED 34,298,2012TOXICOLOGY REVIEW EMMUEG 55,278,2014TOXICOLOGY REVIEW NETEEC 33,608,2011TOXICOLOGY REVIEW MUTAEX 30,89,2014TOXICOLOGY REVIEW FCTOD7 86,298,2015TOXICOLOGY REVIEW MUREAV 770,140,2016TOXICOLOGY REVIEW MUREAV 770,170,2016TOXICOLOGY REVIEW REPTED 73,105,2017TOXICOLOGY REVIEW CCRIF* ,209,2017TOXICOLOGY REVIEW VETOX* ,425,2018Standards and RegulationsOrganization Standard ReferenceEnvironmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES Supported RBREV* -,305,1998Mine Safety and Health Administration (MSHA) STANDARD-air time-weighted average 0.1 mg/m3 (fume,dusts & mists) DTLVS* 3,59,1971Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLVOccupational Exposure Limit-ARAB Republic of Egypt time-weighted average 0.1 mg/m3 (fume), JAN1993Occupational Exposure Limit-AUSTRALIA time-weighted average 0.2 mg/m3 (fume), JUL2008Occupational Exposure Limit-AUSTRALIA time-weighted average 1 mg/m3 (dust and mist), JUL2008Occupational Exposure Limit-BELGIUM time-weighted average 0.2 mg/m3 (fume), MAR2002Occupational Exposure Limit-BELGIUM time-weighted average 1 mg/m3 (dust, aerosol), MAR2002Occupational Exposure Limit-FINLAND time-weighted average 0.1 mg/m3, resp. dust, NOV2011Occupational Exposure Limit-FINLAND time-weighted average 1 mg/m3, NOV2011Occupational Exposure Limit-FRANCE VME 1 mg/m3 (dust), 0.2 mg/m3 (fume), FEB2006Occupational Exposure Limit-GERMANY MAK 0.1 mg/m3, inhal, 2011Occupational Exposure Limit-HUNGARY time-weighted average 0.1 mg/m3 (fume), short term exposure limit 0.4 mg/m3 (fume), SEP2000Occupational Exposure Limit-HUNGARY time-weighted average 1 mg(Cu)/m3, short term exposure limit 4 mg(Cu)/m3, SEP2000Occupational Exposure Limit-HUNGARY time-weighted average 1 mg/m3, short term exposure limit 4 mg/m3, SEP2000Occupational Exposure Limit-ICELAND time-weighted average 0.1 mg(Cu)/m3 (resp. dust), NOV2011Occupational Exposure Limit-INDIA time-weighted average 0.2 mg/m3 (fume), JAN1993Occupational Exposure Limit-JAPAN s2 sen, MAY2012Occupational Exposure Limit-KOREA time-weighted average 0.1 mg/m3 (fume), 2006Occupational Exposure Limit-KOREA time-weighted average 1 mg/m3 (dust and mist), 2006Occupational Exposure Limit-NEW ZEALAND time-weighted average 0.2 mg/m3 (fume), JAN2002Occupational Exposure Limit-NEW ZEALAND time-weighted average 1 mg/m3 (dust and mist), JAN2002Occupational Exposure Limit-NORWAY time-weighted average 0.05 mg(Co)/m3, JAN1999Occupational Exposure Limit-NORWAY time-weighted average 0.1 mg/m3, fume, JAN1999Occupational Exposure Limit-PERU time-weighted average 0.2 mg/m3, JUL2005Occupational Exposure Limit-POLAND MAC(time-weighted average) fume 0.1 mg/m3, MAC(short term exposure limit) fume 0.3 mg/m3, JAN1999Occupational Exposure Limit-POLAND MAC(time-weighted average) dust 1 mg/m3, MAC(short term exposure limit) dust 2 mg/m3, JAN1999Occupational Exposure Limit-RUSSIA time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, JUN2003Occupational Exposure Limit-SWEDEN time-weighted average 1 mg/m3;time-weighted average 0.2 mg/m3 (resp. dust), JUN2005Occupational Exposure Limit-SWITZERLAND MAK-week 0.1 mg/m3, KZG-week 0.2 mg/m3, inhal, JAN2011Occupational Exposure Limit-THAILAND time-weighted average 0.1 mg/m3 (fume), JAN1993Occupational Exposure Limit-THAILAND time-weighted average 1 mg/m3, JAN1993Occupational Exposure Limit-THE NETHERLANDS MAC-TGG 0.2 mg/m3 (fume), 2003Occupational Exposure Limit-THE NETHERLANDS MAC-TGG 1 mg/m3 (dust), 2003Occupational Exposure Limit-THE PHILIPPINES time-weighted average 1.0 mg/m3 (fume), JAN1993Occupational Exposure Limit-UNITED KINGDOM time-weighted average 0.2 mg/m3 (fume), OCT2007Occupational Exposure Limit-UNITED KINGDOM time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3 (dusts and mists), OCT2007Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8H time-weighted average 0.1 mg(Cu)/m3, fume CFRGBR 29,1926.55,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8H time-weighted average 1 mg(Cu)/m3, dusts and mists CFRGBR 29,1926.55,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8H time-weighted average 0.1 mg/m3, fume CFRGBR 41,50-204.50,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8H time-weighted average 1 mg/m3, dusts and mists CFRGBR 41,50-204.50,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8H time-weighted average 0.1 mg(Cu)/m3, fume CFRGBR 29,1910.1000,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8H time-weighted average 1 mg(Cu)/m3, dusts and mists CFRGBR 29,1910.1000,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8H time-weighted average 0.1 mg(Cu)/m3, fume CFRGBR 29,1915.1000,1993Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8H time-weighted average 1 mg(Cu)/m3, dusts and mists CFRGBR 29,1915.1000,1993NIOSH Documentation and SurveillanceOrganization Standard ReferenceNational Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO COPPER, dusts and mists-air 10H time-weighted average 1 mg/m3 NIOSH* DHHS #92-100,1992National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO COPPER, fume-air 10H time-weighted average 0.1 mg/m3 NIOSH* DHHS #92-100,1992National Occupational Exposure Survey 1983 Hazard Code X5915; Number of Industries 5; Total Number of Facilities 162; Number of Occupations 5; Total Number of Employees Exposed 11889; Total Number of Female Employees Exposed 421National Occupational Exposure Survey 1983 Hazard Code X5983; Number of Industries 51; Total Number of Facilities 4558; Number of Occupations 45; Total Number of Employees Exposed 53282; Total Number of Female Employees Exposed 8758National Occupational Exposure Survey 1983 Hazard Code X6807; Number of Industries 2; Total Number of Facilities 16; Number of Occupations 2; Total Number of Employees Exposed 625National Occupational Exposure Survey 1983 Hazard Code X8588; Number of Industries 3; Total Number of Facilities 204; Number of Occupations 7; Total Number of Employees Exposed 9443National Occupational Exposure Survey 1983 Hazard Code 20115; Number of Industries 296; Total Number of Facilities 59839; Number of Occupations 158; Total Number of Employees Exposed 920449; Total Number of Female Employees Exposed 72821National Occupational Hazard Survey 1974 Hazard Code M2276; Number of Industries 27; Total Number of Facilities 1213; Number of Occupations 35; Total Number of Employees Exposed 24737National Occupational Hazard Survey 1974 Hazard Code 20115; Number of Industries 176; Total Number of Facilities 12177; Number of Occupations 105; Total Number of Employees Exposed 224406Status in Federal AgenciesOrganization ReferenceATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180513/AS)EPA TSCA Section 8(b) CHEMICAL INVENTORYEPA TSCA Section 8(d) unpublished health/safety studiesEPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001NIOSH Analytical Method, 1994: Copper (dust and fume), 7029NIOSH Analytical Method, 1994: Elements by ICP, 7300NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005NIOSH Analytical Method, 1994: Metals in urine, 8310On EPA IRIS databaseOSHA ANALYTICAL METHOD #ID121OSHA ANALYTICAL METHOD #ID206Page last reviewed: November 16, 2018Content source: National Institute for Occupational Safety and Health* SyndicateRegistry of Toxic Effects of Chemical Substances (RTECS)* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS DatabaseFollow NIOSH* YouTubeNIOSH Homepage* Workplace Safety & Health Topics* Publications and Products* Programs* Contact NIOSH* About CDC* Contact Us* 800-232-4636Facebook Twitter Instagram LinkedIn Youtube Pinterest SnapchatFacebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat RSS* CONTACT CDCContact UsCall 800-232-4636Email Us* ABOUT CDC+ About CDC+ Jobs+ Funding* POLICIES+ Accessibility+ External Links+ Privacy+ Policies+ Web Policies+ No Fear Act+ FOIA+ OIG+ No Fear Act+ 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