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Original site: www.cdc.gov/niosh-rtecs/DA62CCF8.html | RestoredCDC.org is an independent project, not affiliated with CDC or any federal entity. Visit CDC.gov for free official information. Due to archival on January 6, 2025, recent outbreak data is unavailable. Videos are not restored. Access data.restoredcdc.org for restored data. Use of this site implies acceptance of this disclaimer.[More]About Us Report Bug Compare ContentSkip directly to page optionsThe National Institute for Occupational Safety and Health (NIOSH)Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting PeopleSearchSearch Menu Navigation Menu× NIOSHNIOSH All CDCSubmit* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS Database* The National Institute for Occupational Safety and Health (NIOSH) HomeThe National Institute for Occupational Safety and Health (NIOSH)1. Registry of Toxic Effects of Chemical Substances (RTECS)Benzene, nitro-Related PagesRTECS #DA6475000CAS #98-95-3See: NMAM or OSHA MethodsUpdatedMarch 2019Molecular Weight123.12Molecular FormulaC6H5NO2SynonymsEssence of mirbaneEssence of myrbaneMirbane oilNCI-C60082Nitrobenzeen (Dutch)Nitrobenzen (Polish)NitrobenzeneNitrobenzene (ACGIH:OSHA)NitrobenzolOil of mirbaneOil of myrbaneRCRA waste number U169Skin and Eye Irritation and ReferencesRoute/Organism Dose Effect Referenceeye /rabbit 500 mg/24H mild 85JCAE -,411,1986skin /rabbit 500 mg/24H mild 85JCAE -,411,1986Mutation Data and ReferenceSystem Test Route/Organism/Tissue Dose ReferenceCytogenetic Analysis ovary/hamster 61.3 µmol/L MUREAV 608,28,2006Cytogenetic Analysis intratracheal/hamster 61.3 µmol/L MUREAV 608,28,2006DNA adduct intraperitoneal/mouse 0.1 µg/kg TOLED5 139,25,2003DNA Damage kidney/rat 0.125 mmol/L/20H TXCYAC 204,187,2004DNA Damage oral/rat 300 mg/kg TXCYAC 204,187,2004DNA Damage kidney/human 0.062 mmol/L/20H TXCYAC 204,187,2004micronucleus test kidney/human 0.25 mmol/L/48H TXCYAC 204,187,2004micronucleus test ovary/hamster 0.01 µmol/L/18H ARTODN 78,49,2004micronucleus test kidney/rat 0.125 mmol/L/48H TXCYAC 204,187,2004micronucleus test oral/rat 300 mg/kg TXCYAC 204,187,2004micronucleus test fibroblast/hamster 0.1 µmol/L NSAPCC 369(Suppl 1),R127,2004mutation in microorganisms lung/hamster 200 µg/L (+enzymatic activation step) BLFSBY 39,359,1986Reproductive Effects Data and ReferencesRoute/Organism Dose Effect ReferenceReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)inhalation/rat 5 ppm/6H (90D male) TOXID9 4,181,1984Reproductive: Paternal effects: Testes, epididymis, sperm ductReproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)inhalation/rat 1260 µg/m3/4H (1-21D pregnant) Reproductive: Effects on embryo or fetus: Fetal death GTPZAB 31(4),48,1987Reproductive: Other developmental abnormalitiesReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)inhalation/rat 40 ppm/6H (12W male) Reproductive: Paternal effects: Testes, epididymis, sperm duct FAATDF 8,493,1987Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsinhalation/rabbit 41 ppm/6H (7-19D pregnant) Reproductive: Other effects on female TOXID9 6,93,1986inhalation/rat 40 ppm (70D male/70D prior to copulation/22D pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) REPTED 28,196,2009inhalation/rat 40 ppm (multigeneration) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 28,196,2009Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)oral/rat 300 mg/kg (1D male) TXCYAC 53,219,1988Reproductive: Paternal effects: Testes, epididymis, sperm ductReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)oral/rat 1260 mg/kg (21D male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JTSCDR 20,15,1995Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)oral/rat 3180 mg/kg (2W male/2W pre-3D after birth) JTSCDR 19,141,1994Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)oral/rat 5300 mg/kg (2W male/2W pre-3D after birth) Reproductive: Effects on newborn: Other neonatal measures or effects JTSCDR 19,141,1994Tumorigenic Data and ReferencesRoute/Organism Dose Effect ReferenceTumorigenic: Neoplastic by RTECS criteriainhalation/mouse lowest published toxic concentration: 50 ppm/6H/2Y- intermittent Lung, Thorax, or Respiration: Tumors FAATDF 22,328,1994Skin and Appendages: TumorsTumorigenic: Neoplastic by RTECS criteriainhalation/rat lowest published toxic concentration: 25 ppm/6H/2Y- intermittent FAATDF 22,328,1994Liver: TumorsAcute Toxicity Data and ReferencesRoute/Organism Dose Effect Referenceinhalation/mammal (species unspecified) lethal concentration (50 percent kill): 2 gm/m3 GTPZAB 32(10),25,1988Eye: Lacrimationinhalation/rat lethal concentration (50 percent kill): 556 ppm/4H Behavioral: Tremor NTIS** 0TS0570970Lung, Thorax, or Respiration: CyanosisBehavioral: Altered sleep time (including change in righting reflex)intraperitoneal/guinea pig lowest published lethal dose: 500 mg/kg Behavioral: Muscle contraction or spasticity RMSRA6 16,449,1896Behavioral: ComaBehavioral: General anestheticintraperitoneal/rat lethal dose (50 percent kill): 640 mg/kg Liver: Fatty liver degeneration AGGHAR 17,217,1959Kidney, Ureter, and Bladder: Other changesintravenous/Dog lowest published lethal dose: 150 mg/kg XPHBAO 271,79,1941oral/cat lowest published lethal dose: 1 gm/kg XPHBAO 271,78,1941oral/Dog lowest published lethal dose: 750 mg/kg HBAMAK 4,1375,1935oral/mammal (species unspecified) lethal dose (50 percent kill): 500 mg/kg GTPZAB 32(10),25,1988oral/mouse lowest published toxic dose: 400 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TOLED5 139,1,2003oral/mouse lethal dose (50 percent kill): 590 mg/kg GTPZAB 25(8),50,1981oral/rabbit lowest published lethal dose: 700 mg/kg PCOC** -,805,1966Behavioral: Altered sleep time (including change in righting reflex)oral/rat lethal dose (50 percent kill): 349 mg/kg NTIS** OTS0559505Lung, Thorax, or Respiration: DyspneaCardiac: Cardiomyopathy including infarctionoral/rat lethal dose (50 percent kill): 682 mg/kg Cardiac: EKG changes not diagnostic of above TOVEFN (1),24,2002Cardiac: Other changesBlood: Methemoglobinemia- Carboxhemoglobinemiaoral/rat lethal dose (50 percent kill): 682 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases TOVEFN (1),24,2002Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: DehydrogenasesReproductive: Paternal effects: Testes, epididymis, sperm ductoral/rat lowest published toxic dose: 300 mg/kg REPTED 6,491,1992Related to Chronic Data: Changes in testicular weightLiver: Liver function tests impairedoral/rat lowest published toxic dose: 341 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition TOLED5 135,S132,2002Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidasesoral/rat lowest published toxic dose: 300 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JTSCDR 25,41,2000Behavioral: General anestheticoral/woman lowest published toxic dose: 200 mg/kg Vascular: Other changes ATXKA8 28,208,1971Lung, Thorax, or Respiration: Respiratory stimulationskin/cat lowest published lethal dose: 25 gm/kg HBAMAK 4,1375,1935Behavioral: Somnolence (general depressed activity)skin/mouse lowest published lethal dose: 480 mg/kg Behavioral: Muscle contraction or spasticity XPHBAO 271,79,1941Lung, Thorax, or Respiration: Dyspneaskin/rabbit lowest published lethal dose: 600 mg/kg HBAMAK 4,1375,1935skin/rat lethal dose (50 percent kill): 2100 mg/kg GISAAA 24(9),15,1959subcutaneous/guinea pig lowest published lethal dose: 800 mg/kg HBAMAK 4,1375,1935Behavioral: Somnolence (general depressed activity)subcutaneous/mouse lowest published lethal dose: 286 mg/kg Lung, Thorax, or Respiration: Dyspnea PSEBAA 42,844,1939Lung, Thorax, or Respiration: Other changessubcutaneous/rat lowest published lethal dose: 800 mg/kg HBAMAK 4,1375,1935unreported route/man lowest published lethal dose: 35 mg/kg 85DCAI 2,73,1970unreported route/rat lethal dose (50 percent kill): 460 mg/kg USXXAM #6127591Other Multiple Dose Data and ReferencesRoute/Organism Dose Effect ReferenceEndocrine: Other changesinhalation/mouse lowest published toxic concentration: 50 ppm/6H/90D- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia NTIS** 0TS0570697Blood: Changes in bone marrow not included in aboveBehavioral: Muscle contraction or spasticityinhalation/rat lowest published toxic concentration: 800 µg/m3/24H/73D- continuous Blood: Other changes GISAAA 29(8),5,1964Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseLiver: Hepatitis (hepatocellular necrosis), zonalinhalation/rat lowest published toxic concentration: 50 ppm/6H/90D- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia NTIS** 0TS0570697Blood: Changes in spleeninhalation/rat lowest published toxic concentration: 40 ppm/70D- intermittent Related to Chronic Data: Changes in testicular weight REPTED 28,196,2009Blood: Changes in bone marrow not included in aboveoral/mouse lowest published toxic dose: 1400 mg/kg/14D- intermittent Blood: Changes in spleen DCTODJ 17,271,1994Blood: Changes in other cell count (unspecified)oral/rat lowest published toxic dose: 900 mg/kg/3D- intermittent Blood: Changes in spleen TOXID9 3,125,1983oral/rat lowest published toxic dose: 1960 mg/kg/49D- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JTSCDR 27,11,2002Reproductive: Paternal effects: Testes, epididymis, sperm ductoral/rat lowest published toxic dose: 1080 mg/kg/18D- intermittent JTSCDR 29,217,2004Related to Chronic Data: Changes in testicular weightoral/rat lowest published toxic dose: 180 mg/kg/3D- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JTSCDR 29,217,2004subcutaneous/rat lowest published toxic dose: 1 gm/kg/10D- intermittent Blood: Other changes FATOAO 35,108,1972ReviewsOrganization Standard ReferenceAmerican Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2013American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value-Confirmed animal carcinogen DTLVS* TLV/BEI,2013International Agency for Research on Cancer (IARC) Cancer Review:Animal Sufficient Evidence IMEMDT 65,381,1996International Agency for Research on Cancer (IARC) Cancer Review:Human Inadequate Evidence IMEMDT 65,381,1996International Agency for Research on Cancer (IARC) Cancer Review:Group 2B IMEMDT 65,381,1996TOXICOLOGY REVIEW TOLED5 127,321,2002TOXICOLOGY REVIEW MUREAV 567,227,2004TOXICOLOGY REVIEW MUTAEX 20,389,2005TOXICOLOGY REVIEW MUREAV 628,67,2007TOXICOLOGY REVIEW ENTOX* -,236,2005TOXICOLOGY REVIEW MUREAV 584,1,2005TOXICOLOGY REVIEW MUREAV 682,94,2009TOXICOLOGY REVIEW MUTAEX 26,199,2011TOXICOLOGY REVIEW MUREAV 763,36,2014TOXICOLOGY REVIEW MUREAV 763,181,2015TOXICOLOGY REVIEW RTOPDW 61,251,2011Standards and RegulationsOrganization Standard ReferenceMine Safety and Health Administration (MSHA) STANDARD-air time-weighted average 1 ppm (5 mg/m3) (skin) DTLVS* 3,183,1971Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLVOccupational Exposure Limit-ARAB Republic of Egypt time-weighted average 1 ppm (5 mg/m3), Skin, JAN1993Occupational Exposure Limit-AUSTRALIA time-weighted average 1 ppm (5 mg/m3), JUL2008Occupational Exposure Limit-AUSTRIA MAK-TMW 0.2 ppm (1 mg/m3);KZW 0.8 ppm (4 mg/m3), skin, 2007Occupational Exposure Limit-BELGIUM time-weighted average 0.2 ppm (1 mg/m3), Skin, MAR2002Occupational Exposure Limit-DENMARK time-weighted average 0.2 ppm (1 mg/m3), skin, carc, MAY2011Occupational Exposure Limit-EC time-weighted average 1 mg/m3 (0.2 ppm), skin, FEB2006Occupational Exposure Limit-FINLAND time-weighted average 0.2 ppm (1 mg/m3), short term exposure limit 1 ppm (5.1 mg/m3), skin, NOV2011Occupational Exposure Limit-FRANCE VME 1 ppm (5 mg/m3), C3 Carcinogen, FEB2006Occupational Exposure Limit-HUNGARY time-weighted average 5 mg/m3, short term exposure limit 20 mg/m3, Skin, SEP2000Occupational Exposure Limit-ICELAND time-weighted average 0.2 ppm (1 mg/m3), skin, NOV2011Occupational Exposure Limit-JAPAN Occupational Exposure Limit 1 ppm (5 mg/m3), skin, 2B carc, MAY2012Occupational Exposure Limit-KOREA time-weighted average 1 ppm (5 mg/m3), skin, 2006Occupational Exposure Limit-MEXICO time-weighted average 1 ppm (5 mg/m3);short term exposure limit 2 ppm (10 mg/m3) (skin), 2004Occupational Exposure Limit-NEW ZEALAND time-weighted average 1 ppm (5 mg/m3), skin, JAN2002Occupational Exposure Limit-NORWAY time-weighted average 1 ppm (5 mg/m3), JAN1999Occupational Exposure Limit-PERU time-weighted average 1 ppm (5 mg/m3), JUL2005Occupational Exposure Limit-POLAND MAC(time-weighted average) 3 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999Occupational Exposure Limit-RUSSIA time-weighted average 3 mg/m3, short term exposure limit 6 mg/m3, Skin, JUN2003Occupational Exposure Limit-SWEDEN time-weighted average 1 ppm (5 mg/m3);short term exposure limit 2 ppm (10 mg/m3), Skin, JUN2005Occupational Exposure Limit-SWITZERLAND MAK-week 1 ppm (5 mg/m3), KZG-week 2 ppm (10 mg/m3), carc 3, skin, JAN2011Occupational Exposure Limit-THE NETHERLANDS MAC-TGG 5 mg/m3, Skin, 2003Occupational Exposure Limit-TURKEY time-weighted average 1 ppm (5 mg/m3), Skin, JAN1993Occupational Exposure Limit-UNITED KINGDOM time-weighted average 0.2 ppm (1 mg/m3), skin, OCT2007Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8H time-weighted average 1 ppm (5 mg/m3) (skin) CFRGBR 29,1926.55,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8H time-weighted average 1 ppm (5 mg/m3) (skin) CFRGBR 41,50-204.50,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8H time-weighted average 1 ppm (5 mg/m3) (skin) CFRGBR 29,1910.1000,1994Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8H time-weighted average 1 ppm (5 mg/m3) (skin) CFRGBR 29,1915.1000,1993NIOSH Documentation and SurveillanceOrganization Standard ReferenceNational Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROBENZENE-air 10H time-weighted average 1 ppm (Sk) NIOSH* DHHS #92-100,1992National Occupational Exposure Survey 1983 Hazard Code 50760; Number of Industries 10; Total Number of Facilities 654; Number of Occupations 12; Total Number of Employees Exposed 5080; Total Number of Female Employees Exposed 474National Occupational Hazard Survey 1974 Hazard Code 50760; Number of Industries 21; Total Number of Facilities 1022; Number of Occupations 24; Total Number of Employees Exposed 10578Status in Federal AgenciesOrganization ReferenceATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180398/AS)EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82EPA TSCA Section 8(b) CHEMICAL INVENTORYEPA TSCA Section 8(d) unpublished health/safety studiesEPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8703;8EHQ-0293-8723EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8724;8EHQ-0892-9102EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9103EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001NIOSH Analytical Method, 1994: Nitrobenzenes, 2005NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogenOn EPA IRIS databasePage last reviewed: November 16, 2018Content source: National Institute for Occupational Safety and Health* SyndicateRegistry of Toxic Effects of Chemical Substances (RTECS)* Licensing Agreement Signed for RTECS* How Do I Access the RTECS Database?* Features of the RTECS DatabaseFollow NIOSH* YouTubeNIOSH Homepage* Workplace Safety & Health Topics* Publications and Products* Programs* Contact NIOSH* About CDC* Contact Us* 800-232-4636Facebook Twitter Instagram LinkedIn Youtube Pinterest SnapchatFacebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat RSS* CONTACT 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