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          The National Institute for Occupational Safety and Health (NIOSH)
         1. Registry of Toxic Effects of Chemical Substances (RTECS)
      Benzene, p-dinitro-
            Related Pages
                RTECS #
                  CZ7525000
                CAS #
                  100-25-4
                  See: NMAM or OSHA Methods
                Updated
                  March 2019
                Molecular Weight
                  168.12
                Molecular Formula
                  C6H4N2O4
                Synonyms
                  1,4-Dinitrobenzene
                  Benzene, 1,4-dinitro- (9CI)
                  Dithane A-4
                  p-Dinitrobenzene
                  p-Dinitrobenzene (ACGIH:OSHA)
        Mutation Data and Reference
          System Test                 Route/Organism/Tissue    Dose                                     Reference        
          mutation in microorganisms  /Salmonella typhimurium  5 µg/plate (+enzymatic activation step)  CRNGDP 6,727,1985
          Acute Toxicity Data and References
            Route/Organism       Dose                                     Effect                                               Reference         
            intraperitoneal/rat  lethal dose (50 percent kill): 56 mg/kg  Blood: Methemoglobinemia- Carboxhemoglobinemia       JPETAB 80,31,1944 
            oral/cat             lowest published lethal dose: 29 mg/kg                                                        85KYAH 11,516,1989
                                                                          Lung, Thorax, or Respiration: Cyanosis                                 
            oral/rat             lowest published toxic dose: 5 mg/kg                                                          TXAPA9 92,54,1988 
                                                                          Blood: Changes in spleen                                               
                                                                          Eye: Other eye effects                                                 
            oral/rat             lowest published lethal dose: 50 mg/kg   Behavioral: Somnolence (general depressed activity)  NTIS** OTS0546024 
                                                                          Lung, Thorax, or Respiration: Dyspnea                                  
            Reviews
              Organization                                                       Standard                                                     Reference          
              American Conference of Governmental Industrial Hygienists (ACGIH)  Threshold Limit Value-time-weighted average 0.15 ppm (skin)  DTLVS* TLV/BEI,2013
              TOXICOLOGY REVIEW                                                                                                               RTOPDW 60,120,2011 
              Standards and Regulations
                Organization                                                                                           Standard                                                                                               Reference               
                Mine Safety and Health Administration (MSHA) STANDARD-air                                              time-weighted average 0.15 ppm (1 mg/m3) (skin)                                                        DTLVS* 3,92,1971        
                Occupational Exposure Limit-AUSTRALIA                                                                  time-weighted average 0.15 ppm (1 mg/m3), JUL2008                                                                              
                Occupational Exposure Limit-DENMARK                                                                    time-weighted average 0.15 ppm (1 mg/m3), skin, MAY2011                                                                        
                Occupational Exposure Limit-FINLAND                                                                    time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, skin, NOV2011                                                
                Occupational Exposure Limit-FRANCE                                                                     VME 0.15 ppm (1 mg/m3), FEB2006                                                                                                
                Occupational Exposure Limit-HUNGARY                                                                    time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Skin, SEP2000                                                
                Occupational Exposure Limit-ICELAND                                                                    time-weighted average 0.15 ppm (1 mg/m3), skin, NOV2011                                                                        
                Occupational Exposure Limit-JAPAN                                                                      Occupational Exposure Limit 0.15 ppm (1 mg/m3), skin, MAY2012                                                                  
                Occupational Exposure Limit-KOREA                                                                      time-weighted average 0.15 ppm (1 mg/m3), skin, 2006                                                                           
                Occupational Exposure Limit-NEW ZEALAND                                                                time-weighted average 0.15 ppm (1 mg/m3), skin, JAN2002                                                                        
                Occupational Exposure Limit-PERU                                                                       time-weighted average 0,15 ppm (1 mg/m3), JUL2005                                                                              
                Occupational Exposure Limit-SWEDEN                                                                     time-weighted average 0.15 ppm (1 mg/m3);short term exposure limit 0.3 ppm (2 mg/m3), Skin, JUN2005                            
                Occupational Exposure Limit-SWITZERLAND                                                                MAK-week 0.15 ppm (1 mg/m3), KZG-week 0.3 ppm (2 mg/m3), skin, JAN2011                                                         
                Occupational Exposure Limit-THE NETHERLANDS                                                            MAC-TGG 1 mg/m3, 2003                                                                                                          
                Occupational Exposure Limit-UNITED KINGDOM                                                             time-weighted average 0.15 ppm (1 mg/m3);short term exposure limit 0.5 ppm (3.5 mg/m3), skin, OCT2007                          
                Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)         8H time-weighted average 1 mg/m3 (skin)                                                                CFRGBR 29,1926.55,1994  
                Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)  8H time-weighted average 1 mg/m3 (skin)                                                                CFRGBR 41,50-204.50,1994
                Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)     8H time-weighted average 1 mg/m3 (skin)                                                                CFRGBR 29,1910.1000,1994
                Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)            8H time-weighted average 1 mg/m3 (skin)                                                                CFRGBR 29,1915.1000,1993
                NIOSH Documentation and Surveillance
                  Organization                                                                                                      Standard                                Reference               
                  National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-DINITROBENZENE-air  10H time-weighted average 1 mg/m3 (Sk)  NIOSH* DHHS #92-100,1992
                  Status in Federal Agencies
                    Organization                                               Reference
                    EPA TSCA Section 8(b) CHEMICAL INVENTORY                            
                    EPA TSCA Section 8(d) unpublished health/safety studies             
                    EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001           
                  Page last reviewed: November 16, 2018
                    Content source: National Institute for Occupational Safety and Health
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