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        Tributyl phosphate
          Tributyl phosphate
        Print
          May 1994
          Immediately Dangerous to Life or Health Concentrations (IDLH)
        CAS number: 126–73–8
        NIOSH REL: 0.2 ppm (2.5 mg/m3) TWA
        Current OSHA PEL: 5 mg/m3 TWA
        1989 OSHA PEL: 0.2 ppm (2.5 mg/m3) TWA
        1993-1994 ACGIH TLV: 0.2 ppm (2.2 mg/m3) TWA
        Description of substance: Colorless to pale-yellow, odorless liquid.
        LEL: . . Unknown
        Original (SCP) IDLH: 125 ppm
        Basis for original (SCP) IDLH: The chosen IDLH is based on the only available data on acute inhalation toxicity of exposure to tributyl phosphate. Patty [1963] reported that 0 of 3 rats succumbed to a 6-hour exposure to 123 ppm (1,337 mg/m3) [Fassett]. No other quantitative data are available on which to base the IDLH.
        Short-term exposure guidelines: None developed
        ACUTE TOXICITY DATA:
        Lethal concentration data:
            Species  Reference      LC50(ppm)  LCLo(ppm)  Time    Adjusted 0.5-hrLC (CF)  Derived value
            Cat      Eller 1937     —–         2,214      5 hr    4,760 ppm (2.15)        476 ppm      
            Cat      IPCS 1991      227        —–         4-5 hr  454-488 ppm (2.0/2.15)  45-49 ppm    
            Rat      IPCS 1991      123        —–         6 hr    283 ppm (2.3)           28 ppm       
            Rat      Kalinina 1971  117        —–         ?       ?                       ?            
            Rat      TSCATS         2,529      —–         1 hr    3,161 ppm (1.25)        316 ppm      
          Lethal dose data:
              Species  Reference               Route  LD50(mg/kg)  LDLo(mg/kg)  Adjusted LD  Derived value
              Mouse    Kalinina 1971           oral   1,189        —–           752 ppm      75 ppm       
              Rat      Smyth & Carpenter 1944  oral   3,000        —–           1,897 ppm    190 ppm      
            Other animal data: It has been reported that rats survived a 6-hour exposure to 123 ppm (1,337 mg/m3) [Patty 1963].
            Human data: Nausea and headache have been reported in workers exposed to 15 mg/m3 (1.4 ppm) [Mastromatteo 1964].
              Revised IDLH: 30 ppmBasis for revised IDLH: The revised IDLH for tributyl phosphate is 30 ppm based on acute inhalation toxicity data in animals [IPCS 1991]. This may be a conservative value due to the lack of relevant acute toxicity data in humans exposed to concentrations above 1.4 ppm.
              REFERENCES:
              1. ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600-1601.
              2. Eller H [1937]. Beitrag zur toxikologie technischer weichmachungsmittel (dissertation). Pharmakologishen Institut der Universitat Wursburg, Germany.
              3. Fassett DW [?]. Unpublished data from the Laboratory of Industrial Medicine, Eastman Kodak Company, Rochester, NY. [From Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1915.]
              4. IPCS [1991]. Environmental health criteria 112, tri-n-butyl phosphate. Geneva, Switzerland: World health Organization, International Programme on Chemical Safety. [From ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600-1601.]
              5. Kalinina NI [1971]. Toxicity of phosphoroorganic platificators tributyl phosphate and di(2-ethylhexyl)phenyl phosphate. Gig Tr Prof Zabol 15(8):30-33 (in Russian).
              6. Mastromatteo E [1964]. Personal communication to TLV Committee. [From ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600-1601.]
              7. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1915.
              8. Smyth HF Jr, Carpenter CP [1944]. The place of the range-finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol 26:269-273.
              9. TSCATS. Office of Toxic Substances Report FYI-OTS-0285-0380.
            Last Reviewed: December 4, 2014
              Source: National Institute for Occupational Safety and Health
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