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Original site: www.cdc.gov/cryptococcosis/treatment/index.html | RestoredCDC.org is an independent project, not affiliated with CDC or any federal entity. Visit CDC.gov for free official information. Due to archival on January 6, 2025, recent outbreak data is unavailable. Videos are not restored. Access data.restoredcdc.org for restored data. Use of this site implies acceptance of this disclaimer.
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Cryptococcosis
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Fungal Diseases
April 24, 2024
January 31, 2025
Treatment of Cryptococcosis
Key points
* People who have cryptococcosis need antifungal medication for at least 6 months.
* Treatment for mild-to-moderate lung infections is usually fluconazole.
* People with asymptomatic infections who have HIV/AIDS should be treated with fluconazole.
* The recommended initial treatment for severe lung or brain infections (meningitis) is liposomal amphotericin B with flucytosine.
Treatment
People who have cryptococcosis need to take prescription antifungal medication for at least 6 months, often longer.
Recommended antifungal treatments depend on HIV status and type and severity of infection.
Antifungal treatments depend on HIV status and severity of infection.
The antifungal fluconazole is recommended for treating mild to moderate lung infections and asymptomatic infections in people with HIV/AIDS.
Liposomal amphotericin B and flucytosine are recommended for initial treatment of severe lung infections and cryptococcal meningitis, followed by taking fluconazole.
Additional treatment may be necessary including:
* Lumbar puncture (a needle inserted near the spine removes fluid buildup).
* Surgery to remove fungal growths, known as cryptococcomas.
Treatments may be adapted for other populations like children and people who are pregnant.
Treatments may be adapted for other populations like children and women who are pregnant.
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Cryptococcosis
Cryptococcosis is caused by inhaling Cryptococcus fungal spores. People living with HIV face a higher risk. It usually affects the lungs or brain (meningitis).
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