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                                          第 2 卷第 2 期，2005 年 4 月                                                                                                                                                                                 
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第 2 卷第 2 期，2005 年 4 月
                                          原文出处                                                                                                                                                                                                  
                                          1999–2002 年全国健康和营养调查参加者中的家族病史、糖尿病和其它人口统计数据及风险因素                                                                                                                                                       
 
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                                          Ann M. Annis, RN, MPH, Mark S. Caulder, MS, MPH, Michelle L. Cook, MPH, Debra Duquette, MS, CGC                                                                                                       
                                          建议在引用本文时注明下列出处：由 Annis AM, Caulder MS, Cook ML, Duquette D. 1999–2002所著的《1999–2002 年全国健康和营养调查参加者中的家族病史、糖尿病和其它人口统计数据及风险因素》 [摘要]。2005 年 4 月 [引用日期] 刊载于《慢性疾病预防》[网上期刊]。可从下面网址获取： http://www.cdc.gov/pcd/  
                                          issues/2005/                                                                                                                                                                                          
                                          apr/04_0131_zhs.htm。                                                                                                                                                                                  
                                          经同行评审                                                                                                                                                                                                 
                                          摘要                                                                                                                                                                                                    
                                          简介                                                                                                                                                                                                    
                                          家族糖尿病史已被公认为此疾病的一个重要危险因素。家族病史是颇有价值的基因组信息，因为它代表着环境因素、行为因素和基因因素之间相互影响的特征。本研究调查了在 1999–2002 年全国健康与营养调查的成年人参加者中，家族糖尿病史对自行报告、先前已确诊的糖尿病流行度所产生的影响程度。                                                          
                                          方法                                                                                                                                                                                                    
                                          研究人口包括来自 10,283 位年龄为 20 岁和 20 岁以上参加者的数据。研究调查了与糖尿病状态有关的性别、年龄、民族/族裔、贫困收入比、受教育程度、体重指数以及家族糖尿病史。根据家族病史和其它因素计算得出糖尿病流行度的估计值和比值比。                                                                             
                                          结果                                                                                                                                                                                                    
                                          糖尿病在有一等亲属患有糖尿病的个人中的流行度（14.3%）明显高于没有家族病史的个人（3.2%），相应的粗比值比为 5。随着受糖尿病影响的亲属人数的增加，流行度和比值比估计值也显著增加。家族病史还与几项人口统计数据和危险因素相关。                                                                                   
                                          结论                                                                                                                                                                                                    
                                          调查表明，糖尿病家族病史是糖尿病在成年美国人口中流行度的重要预报指标。我们倡议将家族病史评估包括在公众健康预防和筛查项目中，作为一项成本低廉但价值很高的基因组信息源和测量糖尿病风险的方法。                                                                                                        
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